CH335688A - Verfahren zur Herstellung eines Chemotherapeuticums mit wachstumshemmender Wirkung auf Tumoren - Google Patents
Verfahren zur Herstellung eines Chemotherapeuticums mit wachstumshemmender Wirkung auf TumorenInfo
- Publication number
- CH335688A CH335688A CH335688DA CH335688A CH 335688 A CH335688 A CH 335688A CH 335688D A CH335688D A CH 335688DA CH 335688 A CH335688 A CH 335688A
- Authority
- CH
- Switzerland
- Prior art keywords
- tumors
- growth
- production
- chemotherapeutic agent
- inhibiting effect
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 229940127089 cytotoxic agent Drugs 0.000 title 1
- 230000009422 growth inhibiting effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB335688X | 1953-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH335688A true CH335688A (de) | 1959-01-31 |
Family
ID=10354626
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH339216D CH339216A (de) | 1953-03-17 | 1954-03-17 | Verfahren zur Herstellung eines Chemotherapeuticums mit wachstumshemmender Wirkung auf Tumoren |
| CH335688D CH335688A (de) | 1953-03-17 | 1954-03-17 | Verfahren zur Herstellung eines Chemotherapeuticums mit wachstumshemmender Wirkung auf Tumoren |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH339216D CH339216A (de) | 1953-03-17 | 1954-03-17 | Verfahren zur Herstellung eines Chemotherapeuticums mit wachstumshemmender Wirkung auf Tumoren |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3032584A (de) |
| CH (2) | CH339216A (de) |
| DE (1) | DE965036C (de) |
| FR (1) | FR1160693A (de) |
| GB (1) | GB750155A (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB915751A (en) * | 1960-04-04 | 1963-01-16 | Nat Res Dev | Substituted alanines |
| JPS62192357A (ja) * | 1986-02-19 | 1987-08-22 | Kureha Chem Ind Co Ltd | Ｎ−フタロイル−ｐ−ニトロ−Ｌ−フエニルアラニンの製造方法 |
| US4835182A (en) * | 1987-08-21 | 1989-05-30 | The United States Of America As Represented By The Department Of Health And Human Services | Enhancing drug delivery to the brain |
| GB8727157D0 (en) * | 1987-11-19 | 1987-12-23 | Wellcome Found | Pharmaceutical formulations |
| GB8820850D0 (en) * | 1988-09-05 | 1988-10-05 | Cancer Res Campaign Tech | Improvements relating to pro-drugs |
| CN1141929C (zh) * | 1996-02-12 | 2004-03-17 | O·I·伊普施廷 | 药物制剂 |
| US20040072889A1 (en) * | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
| JP2003501488A (ja) * | 1999-06-11 | 2003-01-14 | ネオルックス コーポレイション | 骨髄抑制のための高投与量放射性核種錯体 |
| US7094885B2 (en) | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
| US6992207B2 (en) * | 2000-06-13 | 2006-01-31 | Oncopeptides Ab | Melphalan derivatives and their use as cancer chemotherapeutic drugs |
| SE0002202D0 (sv) | 2000-06-13 | 2000-06-13 | Karolinska Innovations Ab | New peptides |
| RU2181297C2 (ru) | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Способ лечения патологического синдрома и лекарственное средство |
| JP2004536034A (ja) * | 2001-01-08 | 2004-12-02 | ネオルクス コーポレイション | 治療的および診断的化合物、組成物および方法 |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| UA76639C2 (uk) * | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Гомеопатичний лікарський засіб та спосіб лікування еректильних дисфункцій |
| RU2253478C1 (ru) * | 2003-10-01 | 2005-06-10 | Эпштейн Олег Ильич | Средство для потенцирования лечебных эффектов - усиления действия лекарственного вещества |
| WO2007096647A2 (en) * | 2006-02-27 | 2007-08-30 | Sterix Limited | Diaryl compounds as non-steroidal inhibitors of 17-beta hydroxysteroid dehydrogenase and/or steroid sulphatase for the treatment of oestrogen-related diseases such as hormone dependent breast cancer |
| CN100491339C (zh) * | 2007-04-20 | 2009-05-27 | 苏州市立德化学有限公司 | 一种抗肿瘤药物美法仑的合成工艺 |
| CA2720271A1 (en) * | 2008-02-15 | 2009-08-20 | Board Of Regents Of The University Of Texas System | Compositions and methods for treating lung cancer |
| WO2009117164A1 (en) * | 2008-03-20 | 2009-09-24 | Navinta Llc | Process of making optically pure melphalan |
| EP2191840A1 (de) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumorkombinationen mit Antikörpern, die insbesondere CD38 und Melphalan erkennen |
| JP5709766B2 (ja) | 2009-03-12 | 2015-04-30 | ジェネンテック， インコーポレイテッド | 造血器腫瘍の治療のためのホスホイノシチド３キナーゼ阻害剤化合物と化学療法剤の併用 |
| CA2763365C (en) * | 2009-05-29 | 2016-09-13 | Cydex Pharmaceuticals, Inc. | Injectable melphalan compositions comprising a cyclodextrin derivative and methods of making and using the same |
| US11020363B2 (en) | 2009-05-29 | 2021-06-01 | Cydex Pharmaceuticals, Inc. | Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same |
| ES2557316T3 (es) | 2009-09-08 | 2016-01-25 | F. Hoffmann-La Roche Ag | Compuestos de piridín-3-il-carboxamida 4-sustituidos y métodos de utilización |
| AR077384A1 (es) | 2010-07-05 | 2011-08-24 | Eriochem Sa | Una formulacion farmaceutica inyectable de melfalano. |
| US9308275B2 (en) | 2010-07-15 | 2016-04-12 | Oleg Iliich Epshtein | Method of increasing the effect of an activated-potentiated form of an antibody |
| CN102030671B (zh) * | 2010-10-26 | 2014-02-19 | 浙江凯普化工有限公司 | 医药级美法仑及其盐酸一盐、二盐的制备方法 |
| US8921596B2 (en) | 2010-11-04 | 2014-12-30 | Emcure Pharmaceuticals, Ltd. | Process for the preparation of melphalan hydrochloride |
| UA112170C2 (uk) | 2010-12-10 | 2016-08-10 | Санофі | Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб |
| RS60719B1 (sr) | 2011-04-28 | 2020-09-30 | Oncopeptides Ab | Liofilizovani preparat citotoksičnih dipeptida |
| CN102757357B (zh) * | 2012-07-25 | 2014-04-23 | 平湖优康药物研发中心 | 一种抗肿瘤药物美法仑的合成工艺 |
| EP2970102B1 (de) | 2013-03-11 | 2019-05-08 | Biophore India Pharmaceuticals Pvt. Ltd. | Verbessertes verfahren zur synthese von melphalan und hydrochloridsalz |
| ITMI20130896A1 (it) | 2013-05-31 | 2014-12-01 | Farmabios Spa | Processo di purificazione di melphalan |
| KR20170110083A (ko) | 2014-12-23 | 2017-10-10 | 인털렉츄얼 프라퍼티 어쏘시에이츠, 엘엘씨 | 경피 투여를 위한 방법 및 제형 |
| JP2020534285A (ja) | 2017-09-15 | 2020-11-26 | アンパサンド バイオファーマシューティカルズ インコーポレイテッドＡｍｐｅｒｓａｎｄ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | 投与および処置の方法 |
| IT201900025348A1 (it) * | 2019-12-23 | 2021-06-23 | Indena Spa | Procedimento per la sintesi di melfalan |
| CN114315618A (zh) * | 2021-12-04 | 2022-04-12 | 浙江恒腾福生物科技集团有限公司 | 一种合成美法仑的制备方法 |
-
1953
- 1953-03-17 GB GB7371/53A patent/GB750155A/en not_active Expired
-
1954
- 1954-03-12 US US415964A patent/US3032584A/en not_active Expired - Lifetime
- 1954-03-16 FR FR1160693D patent/FR1160693A/fr not_active Expired
- 1954-03-17 DE DEN8634A patent/DE965036C/de not_active Expired
- 1954-03-17 CH CH339216D patent/CH339216A/de unknown
- 1954-03-17 CH CH335688D patent/CH335688A/de unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE965036C (de) | 1957-05-29 |
| CH339216A (de) | 1959-06-30 |
| GB750155A (en) | 1956-06-13 |
| FR1160693A (fr) | 1958-07-24 |
| US3032584A (en) | 1962-05-01 |
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