CH310720A - Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. - Google Patents

Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

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Publication number
CH310720A
CH310720A CH310720DA CH310720A CH 310720 A CH310720 A CH 310720A CH 310720D A CH310720D A CH 310720DA CH 310720 A CH310720 A CH 310720A
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CH
Switzerland
Prior art keywords
bis
ethoxy
dimethyl
octane
preparation
Prior art date
Application number
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German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH310720A publication Critical patent/CH310720A/en

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Description

  

  



  Verfahren zur Herstellung einer quatemären Ammoniumverbindung eines   Bis-aminoalkoxy-alkans.   



   Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung einer quaternären Ammoniumverbindung eines Bis-aminoalkoxy  sukans.    Das Verfahren ist dadurch gekenn  teiehnet, dass ma. n aut 1    Mol   1,    8-bis-(ss-bromithoxy)-octan 2 Mol Dimethyl-n-hexylamin einwirken lässt.



   Die   erhaltene neue Verbindmg,    das   1,    8 Bis- [ss-(n-hexyl-dimethyl-ammonium)-äthyoxy]octan-dibromid, schmilzt bei   130 .    Sie soll als Arzneimittel und als Zwischenprodukt für Arzneimittel Verwendung finden.



   Beispiel :
3, 6 Teile reines 1, 8-Bis-   (-brom-äthoxy)-    octan,   20    Volumteile trockenes Aceton und 2,   92    Teile reines   Dimetlyl-n-hexylamin    werclen im   Einsehmelzrohr    14 Stunden auf 90 bis   100     erhitzt. Nach Erkalten wird abgesaugt und das erhaltene 1, 8-Bis-   [} S-    (n-hexyl-dime  thyl-ammonium)-äthoxy]-octan-dibromid    aus wenig abs. Methanol, unter Zusatz von Butanon, umkristallisiert. Es schmilzt bei   130 .     



   PATENTANSPRUCH :
Verfahren zur Herstellung einer quater  nären Ammoniumverbindung    eines Bis-amino   alkoxy-alkans, dadurch gekennzeichnet, dass    man auf 1 Mol 1, 8-bis-(ss-borom-äthoxy)-ectan   2    Mol Dimethyl-n-hexylamin einwirken lässt.



   Die erhaltene neue Verbindung, das 1, 8 Bis-   [B-(n-hexyl-dimethyl-ammonium)-äthoxy]-      octan-dibromid,    sehmilzt bei   130 .    

**WARNUNG** Ende DESC Feld konnte Anfang CLMS uberlappen**.





  



  Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxyalkane.



   The present patent is a process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy sukans. The method is characterized in that ma. N allows 2 moles of dimethyl-n-hexylamine to act on 1 mole of 1,8-bis- (ss-bromithoxy) octane.



   The new compound obtained, 1.8 bis- [ss- (n-hexyl-dimethyl-ammonium) ethoxy] octane dibromide, melts at 130. It is intended to be used as a medicinal product and as an intermediate for medicinal products.



   Example:
3.6 parts of pure 1,8-bis- (-bromo-ethoxy) -octane, 20 parts by volume of dry acetone and 2.92 parts of pure dimethyl-n-hexylamine are heated to 90 to 100 for 14 hours in a single drum. After cooling, it is suctioned off and the 1,8-bis [} S- (n-hexyl-dimethylammonium) ethoxy] octane dibromide obtained from a little abs. Methanol, with the addition of butanone, recrystallized. It melts at 130.



   PATENT CLAIM:
Process for the preparation of a quaternary ammonium compound of a bis-amino alkoxy-alkane, characterized in that 2 moles of dimethyl-n-hexylamine are allowed to act on 1 mole of 1,8-bis- (ss-borom-ethoxy) -ectane.



   The new compound obtained, 1.8 bis- [B- (n-hexyl-dimethyl-ammonium) -ethoxy] -octane-dibromide, melts at 130.

** WARNING ** End of DESC field could overlap beginning of CLMS **.

Claims (1)

**WARNUNG** Anfang CLMS Feld konnte Ende DESC uberlappen **. ** WARNING ** Beginning of CLMS field could overlap end of DESC **. Verfahren zur Herstellung einer quatemären Ammoniumverbindung eines Bis-aminoalkoxy-alkans. Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxyalkane. Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung einer quaternären Ammoniumverbindung eines Bis-aminoalkoxy sukans. Das Verfahren ist dadurch gekenn teiehnet, dass ma. n aut 1 Mol 1, 8-bis-(ss-bromithoxy)-octan 2 Mol Dimethyl-n-hexylamin einwirken lässt. The present patent is a process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy sukans. The method is characterized in that ma. N allows 2 moles of dimethyl-n-hexylamine to act on 1 mole of 1,8-bis- (ss-bromithoxy) octane. Die erhaltene neue Verbindmg, das 1, 8 Bis- [ss-(n-hexyl-dimethyl-ammonium)-äthyoxy]octan-dibromid, schmilzt bei 130 . Sie soll als Arzneimittel und als Zwischenprodukt für Arzneimittel Verwendung finden. The new compound obtained, 1.8 bis- [ss- (n-hexyl-dimethyl-ammonium) ethoxy] octane dibromide, melts at 130. It is intended to be used as a medicinal product and as an intermediate for medicinal products. Beispiel : 3, 6 Teile reines 1, 8-Bis- (-brom-äthoxy)- octan, 20 Volumteile trockenes Aceton und 2, 92 Teile reines Dimetlyl-n-hexylamin werclen im Einsehmelzrohr 14 Stunden auf 90 bis 100 erhitzt. Nach Erkalten wird abgesaugt und das erhaltene 1, 8-Bis- [} S- (n-hexyl-dime thyl-ammonium)-äthoxy]-octan-dibromid aus wenig abs. Methanol, unter Zusatz von Butanon, umkristallisiert. Es schmilzt bei 130 . Example: 3.6 parts of pure 1,8-bis- (-bromo-ethoxy) -octane, 20 parts by volume of dry acetone and 2.92 parts of pure dimethyl-n-hexylamine are heated to 90 to 100 for 14 hours in a single drum. After cooling, it is suctioned off and the 1,8-bis [} S- (n-hexyl-dimethylammonium) ethoxy] octane dibromide obtained from a little abs. Methanol, with the addition of butanone, recrystallized. It melts at 130. PATENTANSPRUCH : Verfahren zur Herstellung einer quater nären Ammoniumverbindung eines Bis-amino alkoxy-alkans, dadurch gekennzeichnet, dass man auf 1 Mol 1, 8-bis-(ss-borom-äthoxy)-ectan 2 Mol Dimethyl-n-hexylamin einwirken lässt. PATENT CLAIM: Process for the preparation of a quaternary ammonium compound of a bis-amino alkoxy-alkane, characterized in that 2 moles of dimethyl-n-hexylamine are allowed to act on 1 mole of 1,8-bis- (ss-borom-ethoxy) -ectane. Die erhaltene neue Verbindung, das 1, 8 Bis- [B-(n-hexyl-dimethyl-ammonium)-äthoxy]- octan-dibromid, sehmilzt bei 130 . The new compound obtained, 1.8 bis- [B- (n-hexyl-dimethyl-ammonium) -ethoxy] -octane-dibromide, melts at 130.
CH310720D 1952-06-13 1952-06-13 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. CH310720A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH310720T 1952-06-13
CH308688T 1955-07-31

Publications (1)

Publication Number Publication Date
CH310720A true CH310720A (en) 1955-10-31

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CH310720D CH310720A (en) 1952-06-13 1952-06-13 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Country Status (1)

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CH (1) CH310720A (en)

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