CH305972A - Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. - Google Patents

Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

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Publication number
CH305972A
CH305972A CH305972DA CH305972A CH 305972 A CH305972 A CH 305972A CH 305972D A CH305972D A CH 305972DA CH 305972 A CH305972 A CH 305972A
Authority
CH
Switzerland
Prior art keywords
bis
ethoxy
alkane
preparation
decane
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH305972A publication Critical patent/CH305972A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  



  Verfahren zur Herstellung einer quaternären Ammoniumverbindung eines   Bis-aminoalkoxy-alkans.   



   Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung einer quaternären Ammoniumverbindung eines Bis-aminoalkoxy-alkans. Das Verfahren ist dadurch gekennzeichnet, da. man auf ein Mol   1,    10-Bis  (ss-brom-äthoxy)-dekan    zwei Mol   Benzyldime-      thylamin    einwirken lässt.



   Die erhaltene neue Verbindung, das 1,10 Bis-   [ss-      (dimeths7l-benzyl-ammonium)-äthoxv]-       dekan-dibromid,    schmilzt bei   138 .    Sie soll als
Arzneimittel und-als Zwischenprodukt für
Arzneimittel Verwendung finden.



   Beispiel :
3,88 Teile   1,      10-Bis-(ss-brom-äthoxy)-dekan    werden in 12 Teilen abs. Methanol gelost, mit    16    Teilen einer benzolischen   Losung    von Ben zyldimethylamin   (32 /oig)    versetzt und   ira       Einschmelzrohr    4 Stunden im siedenden Was serbad erwärmt. Die Lösung wird mit etwas trockenem Essigester versetzt, bis zur begin nenden Kristallisation eingedampft und erkal ten gelassen. Nach Umkristallisation aus Buta non + Alkohol schmilzt das erhaltene 1,10
Bis-   [ss-      (dimethyl-benzyl-ammonium)-äthoxy]-    'dekan-dibromid bei   138 .     



   PATENTANSPRUCH :
Verfahren zur Herstellung einer quater    nären    Ammoniumverbindimg eines Bis-amino    alkoxy-alkans,    dadurch gekennzeichnet, dass man auf ein Mol   1,      10-Bis-(ss-brom-äthoxy)-    dekan zwei Mol Benzyldimethylamin einwir ken lässt.



   Die erhaltene neue Verbindung, das 1,10
Bis-   [ 8- (dimethyl-benzyl-ammonium)-äthoxy]    dekan-dibromid, schmilzt bei   138 .    

**WARNUNG** Ende DESC Feld konnte Anfang CLMS uberlappen**.





  



  Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.



   The present patent relates to a process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. The method is characterized because. one mole of 1, 10-bis (ss-bromo-ethoxy) decane is allowed to act with two moles of benzyldimethylamine.



   The new compound obtained, 1.10 bis- [ss- (dimeths7l-benzyl-ammonium) -ethoxv] - decane dibromide, melts at 138. She is supposed to be
Medicinal products and-as an intermediate for
Find medicinal use.



   Example:
3.88 parts of 1, 10-bis (ss-bromo-ethoxy) -dekan are abs in 12 parts. Dissolved methanol, mixed with 16 parts of a benzene solution of benzyldimethylamine (32%) and heated in the melting tube for 4 hours in a boiling water bath. The solution is mixed with a little dry ethyl acetate, evaporated until the beginning of crystallization and allowed to cool. After recrystallization from buta non + alcohol, the 1.10 obtained melts
Bis- [ss- (dimethyl-benzyl-ammonium) -ethoxy] - 'decane dibromide at 138.



   PATENT CLAIM:
Process for the preparation of a quaternary ammonium compound of a bis-amino alkoxy-alkane, characterized in that two moles of benzyldimethylamine are allowed to act on one mole of 1, 10-bis- (ß-bromo-ethoxy) decane.



   The new compound obtained, the 1.10
Bis- [8- (dimethyl-benzyl-ammonium) -ethoxy] decane dibromide, melts at 138.

** WARNING ** End of DESC field could overlap beginning of CLMS **.

Claims (1)

**WARNUNG** Anfang CLMS Feld konnte Ende DESC uberlappen **. ** WARNING ** Beginning of CLMS field could overlap end of DESC **. Verfahren zur Herstellung einer quaternären Ammoniumverbindung eines Bis-aminoalkoxy-alkans. Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung einer quaternären Ammoniumverbindung eines Bis-aminoalkoxy-alkans. Das Verfahren ist dadurch gekennzeichnet, da. man auf ein Mol 1, 10-Bis (ss-brom-äthoxy)-dekan zwei Mol Benzyldime- thylamin einwirken lässt. The present patent relates to a process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. The method is characterized because. one mole of 1, 10-bis (ss-bromo-ethoxy) decane is allowed to act with two moles of benzyldimethylamine. Die erhaltene neue Verbindung, das 1,10 Bis- [ss- (dimeths7l-benzyl-ammonium)-äthoxv]- dekan-dibromid, schmilzt bei 138 . Sie soll als Arzneimittel und-als Zwischenprodukt für Arzneimittel Verwendung finden. The new compound obtained, 1.10 bis- [ss- (dimeths7l-benzyl-ammonium) -ethoxv] - decane dibromide, melts at 138. She is supposed to be Medicinal products and-as an intermediate for Find medicinal use. Beispiel : 3,88 Teile 1, 10-Bis-(ss-brom-äthoxy)-dekan werden in 12 Teilen abs. Methanol gelost, mit 16 Teilen einer benzolischen Losung von Ben zyldimethylamin (32 /oig) versetzt und ira Einschmelzrohr 4 Stunden im siedenden Was serbad erwärmt. Die Lösung wird mit etwas trockenem Essigester versetzt, bis zur begin nenden Kristallisation eingedampft und erkal ten gelassen. Nach Umkristallisation aus Buta non + Alkohol schmilzt das erhaltene 1,10 Bis- [ss- (dimethyl-benzyl-ammonium)-äthoxy]- 'dekan-dibromid bei 138 . Example: 3.88 parts of 1, 10-bis (ss-bromo-ethoxy) -dekan are abs in 12 parts. Dissolved methanol, mixed with 16 parts of a benzene solution of benzyldimethylamine (32%) and heated in the melting tube for 4 hours in a boiling water bath. The solution is mixed with a little dry ethyl acetate, evaporated until the beginning of crystallization and allowed to cool. After recrystallization from buta non + alcohol, the 1.10 obtained melts Bis- [ss- (dimethyl-benzyl-ammonium) -ethoxy] - 'decane dibromide at 138. PATENTANSPRUCH : Verfahren zur Herstellung einer quater nären Ammoniumverbindimg eines Bis-amino alkoxy-alkans, dadurch gekennzeichnet, dass man auf ein Mol 1, 10-Bis-(ss-brom-äthoxy)- dekan zwei Mol Benzyldimethylamin einwir ken lässt. PATENT CLAIM: Process for the preparation of a quaternary ammonium compound of a bis-amino alkoxy-alkane, characterized in that two moles of benzyldimethylamine are allowed to act on one mole of 1, 10-bis- (ß-bromo-ethoxy) decane. Die erhaltene neue Verbindung, das 1,10 Bis- [ 8- (dimethyl-benzyl-ammonium)-äthoxy] dekan-dibromid, schmilzt bei 138 . The new compound obtained, the 1.10 Bis- [8- (dimethyl-benzyl-ammonium) -ethoxy] decane dibromide, melts at 138.
CH305972D 1952-04-21 1952-04-21 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. CH305972A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH305972T 1952-04-21
CH291680T 1952-04-21

Publications (1)

Publication Number Publication Date
CH305972A true CH305972A (en) 1955-03-15

Family

ID=25733129

Family Applications (1)

Application Number Title Priority Date Filing Date
CH305972D CH305972A (en) 1952-04-21 1952-04-21 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Country Status (1)

Country Link
CH (1) CH305972A (en)

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