CH329927A - Process for the preparation of a new quaternary ammonium compound - Google Patents

Process for the preparation of a new quaternary ammonium compound

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Publication number
CH329927A
CH329927A CH329927DA CH329927A CH 329927 A CH329927 A CH 329927A CH 329927D A CH329927D A CH 329927DA CH 329927 A CH329927 A CH 329927A
Authority
CH
Switzerland
Prior art keywords
preparation
quaternary ammonium
dioxy
benzene
ammonium compound
Prior art date
Application number
Other languages
German (de)
Inventor
Rauch Hubert
Original Assignee
Rauch Hubert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rauch Hubert filed Critical Rauch Hubert
Publication of CH329927A publication Critical patent/CH329927A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

  

  
 



  Verfahren zur Herstellung einer neuen quaternären   Ammoniumverindung   
Gegenstand des vorliegenden Patentes ist ein Verfahren zur Herstellung einer neuen quaternären Ammoniumverbindung, welches dadurch gekennzeichnet ist, dass man auf den 2,3-Dioxy-propyläther des   m-Dimethylamino-    phenols Methylbromid einwirken lässt. Die Anlagerung erfolgt meist schon in der Kälte; sie wird durch Erwärmen beschleunigt und vervollständigt Die Quaternisierung kann in An oder Abwesenheit eines   Lösungs- oder    Verdünnungsmittels, wie Methanol,   Äilyl    alkohol, Aceton, Benzol, Toluol oder dergleichen, vorgenommen werden.



   Die neue Verbindung soll für therapeutische Zwecke Verwendung finden.



   Beispiel
211 Teile   2, 3-Dioxy-propyl-äther    des   m-Dimethylamino-phenols    werden in 800 Teilen Benzol gelöst und mit einer Lösung von 100 Teilen Brommethyl in 500 Teilen Benzol versetzt; das Reaktionsgemisch wird 12 Stunden bei gewöhnlicher Temperatur stehengelassen und hernach 4 Stunden unter Rühren auf   50     erwärmt. Nach dem Abkühlen scheidet sich das Methylbromid des   2,3-Dioxy-propyl-       m.-dimethylamino-phenyläthers kristallinisch    ab; es schmilzt bei   168/169 ,    ist in Wasser und Alkohol löslich, in Benzol schwer lös  lich.     



   PATENTANSPRUCH
Verfahren zur Herstellung einer neuen quaternären   Ammoniumverbindung,    dadurch gekennzeichnet, dass man den   2,3-Dioxy-pro-    pyläther des   m-Dimethylamino-phenols mit    Methylbromid behandelt. 

**WARNUNG** Ende DESC Feld konnte Anfang CLMS uberlappen**.



   



  
 



  Process for the preparation of a new quaternary ammonium compound
The subject of the present patent is a process for the preparation of a new quaternary ammonium compound, which is characterized in that methyl bromide is allowed to act on the 2,3-dioxy-propyl ether of m-dimethylaminophenol. The accumulation usually takes place in the cold; it is accelerated and completed by heating. The quaternization can be carried out in the presence or absence of a solvent or diluent such as methanol, ethyl alcohol, acetone, benzene, toluene or the like.



   The new compound is intended to be used for therapeutic purposes.



   example
211 parts of 2,3-dioxy-propyl-ether of m-dimethylaminophenol are dissolved in 800 parts of benzene and mixed with a solution of 100 parts of bromomethyl in 500 parts of benzene; the reaction mixture is left to stand for 12 hours at ordinary temperature and then heated to 50 for 4 hours with stirring. After cooling, the methyl bromide of 2,3-dioxy-propyl-m.-dimethylaminophenyl ether separates out in crystalline form; it melts at 168/169, is soluble in water and alcohol, and sparingly soluble in benzene.



   PATENT CLAIM
Process for the preparation of a new quaternary ammonium compound, characterized in that the 2,3-dioxy-propyl ether of m-dimethylaminophenol is treated with methyl bromide.

** WARNING ** End of DESC field could overlap beginning of CLMS **.

Claims (1)

**WARNUNG** Anfang CLMS Feld konnte Ende DESC uberlappen **. ** WARNING ** Beginning of CLMS field could overlap end of DESC **. Verfahren zur Herstellung einer neuen quaternären Ammoniumverindung Gegenstand des vorliegenden Patentes ist ein Verfahren zur Herstellung einer neuen quaternären Ammoniumverbindung, welches dadurch gekennzeichnet ist, dass man auf den 2,3-Dioxy-propyläther des m-Dimethylamino- phenols Methylbromid einwirken lässt. Die Anlagerung erfolgt meist schon in der Kälte; sie wird durch Erwärmen beschleunigt und vervollständigt Die Quaternisierung kann in An oder Abwesenheit eines Lösungs- oder Verdünnungsmittels, wie Methanol, Äilyl alkohol, Aceton, Benzol, Toluol oder dergleichen, vorgenommen werden. Process for the preparation of a new quaternary ammonium compound The subject of the present patent is a process for the preparation of a new quaternary ammonium compound, which is characterized in that methyl bromide is allowed to act on the 2,3-dioxy-propyl ether of m-dimethylaminophenol. The accumulation usually takes place in the cold; it is accelerated and completed by heating. The quaternization can be carried out in the presence or absence of a solvent or diluent such as methanol, ethyl alcohol, acetone, benzene, toluene or the like. Die neue Verbindung soll für therapeutische Zwecke Verwendung finden. The new compound is intended to be used for therapeutic purposes. Beispiel 211 Teile 2, 3-Dioxy-propyl-äther des m-Dimethylamino-phenols werden in 800 Teilen Benzol gelöst und mit einer Lösung von 100 Teilen Brommethyl in 500 Teilen Benzol versetzt; das Reaktionsgemisch wird 12 Stunden bei gewöhnlicher Temperatur stehengelassen und hernach 4 Stunden unter Rühren auf 50 erwärmt. Nach dem Abkühlen scheidet sich das Methylbromid des 2,3-Dioxy-propyl- m.-dimethylamino-phenyläthers kristallinisch ab; es schmilzt bei 168/169 , ist in Wasser und Alkohol löslich, in Benzol schwer lös lich. example 211 parts of 2,3-dioxy-propyl-ether of m-dimethylaminophenol are dissolved in 800 parts of benzene and mixed with a solution of 100 parts of bromomethyl in 500 parts of benzene; the reaction mixture is left to stand for 12 hours at ordinary temperature and then heated to 50 for 4 hours with stirring. After cooling, the methyl bromide of 2,3-dioxy-propyl-m.-dimethylaminophenyl ether separates out in crystalline form; it melts at 168/169, is soluble in water and alcohol, and sparingly soluble in benzene. PATENTANSPRUCH Verfahren zur Herstellung einer neuen quaternären Ammoniumverbindung, dadurch gekennzeichnet, dass man den 2,3-Dioxy-pro- pyläther des m-Dimethylamino-phenols mit Methylbromid behandelt. PATENT CLAIM Process for the preparation of a new quaternary ammonium compound, characterized in that the 2,3-dioxy-propyl ether of m-dimethylaminophenol is treated with methyl bromide.
CH329927D 1954-11-08 1954-11-08 Process for the preparation of a new quaternary ammonium compound CH329927A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH329927T 1954-11-08

Publications (1)

Publication Number Publication Date
CH329927A true CH329927A (en) 1958-05-15

Family

ID=4501505

Family Applications (1)

Application Number Title Priority Date Filing Date
CH329927D CH329927A (en) 1954-11-08 1954-11-08 Process for the preparation of a new quaternary ammonium compound

Country Status (1)

Country Link
CH (1) CH329927A (en)

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