CH206550A - Process for the preparation of a new carbonic acid derivative. - Google Patents

Process for the preparation of a new carbonic acid derivative.

Info

Publication number
CH206550A
CH206550A CH206550DA CH206550A CH 206550 A CH206550 A CH 206550A CH 206550D A CH206550D A CH 206550DA CH 206550 A CH206550 A CH 206550A
Authority
CH
Switzerland
Prior art keywords
carbonic acid
preparation
acid derivative
new
diethylamino
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH206550A publication Critical patent/CH206550A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Darstellung eines neuen     gohlensäurederivates.       Gegenstand des vorliegenden Patentes  ist ein Verfahren zur Darstellung eines neuen       Kohlensäurederivates,    welches dadurch ge  kennzeichnet ist, dass man auf     Testosteron-          chlorkohlensäureester        ,Q-Diäthylamino-äthanol     einwirken lässt.  



  Das so gewonnene Hydrochlorid des     (3-          Diäthylamino-äthyl-kohlensäureesters    des     Te-          stosterons    bildet in Wasser sehr leicht lös  liche, bei     178-180'    schmelzende Kristalle.  



  Die neue Verbindung soll therapeutische  Verwendung finden.  



  <I>Beispiel:</I>  Eine Lösung von 0,7 Teilen     Testosteron-          chlorkohlensäureesterin    3 Teilen Benzol wird  mit einer Lösung von -0,5 Teilen     ss-Diäthyl-          amino-äthanol    in 3 Teilen Benzol vermischt.  Nach einigem Stehen ist die Umsetzung be  endet. Man versetzt mit Wasser und trennt  die     Benzolschicht    ab. Sie wird gewaschen,  getrocknet und verdampft. Der ölige Rück  stand wird in Äther gelöst und mit ätheri  scher Salzsäure versetzt.

   Das ausgeschiedene    Hydrochlorid     desss-Diäthylamino-ätbyl-kohlen-          säureesters    des Testosterons wird aus     Aceton-          isopropyläther    umkristallisiert.



  Process for the preparation of a new carbonic acid derivative. The subject of the present patent is a method for the preparation of a new carbonic acid derivative, which is characterized in that testosterone chlorocarbonic acid ester, Q-diethylamino-ethanol, is allowed to act.



  The hydrochloride of the 3-diethylamino-ethyl-carbonic acid ester of testosterone thus obtained forms crystals which are very easily soluble in water and melt at 178-180 °.



  The new compound should find therapeutic use.



  <I> Example: </I> A solution of 0.7 parts of testosterone chlorocarbonate in 3 parts of benzene is mixed with a solution of -0.5 parts of ß-diethylamino-ethanol in 3 parts of benzene. The implementation is over after standing for a while. Water is added and the benzene layer is separated off. It is washed, dried and evaporated. The oily residue is dissolved in ether and ethereal hydrochloric acid is added.

   The precipitated hydrochloride of the diethylamino-ethyl-carbonic acid ester of testosterone is recrystallized from acetone isopropyl ether.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines neuen Kohlensäurederivates, dadurcb gekennzeichnet, dass man auf Testosteron-chlorkohlensäure- ester ss-Diäthylamino-äthanol einwirken lässt. Das so gewonnene Hydrochlorid des P Diäthylamino - äthyl - kohlensäureesters des Testosterons bildet in Wasser sehr leicht lösliche, bei 178-180 schmelzende Kristalle. Die neue Verbindung soll therapeutische Verwendung finden. PATENT CLAIM: Process for the preparation of a new carbonic acid derivative, characterized by the fact that testosterone-chlorocarbonic acid ester ß-diethylamino-ethanol is allowed to act. The hydrochloride of the diethylamino-ethyl-carbonic acid ester of testosterone obtained in this way forms crystals which are very easily soluble in water and melt at 178-180. The new compound should find therapeutic use. UNTERANSPRUCH: Verfahren nach Patentansprucb, dadurch gekennzeichnet, dass man die Reaktion in Gegenwart eines organischen Lösungsmittels ausführt. SUBCLAIM: Process according to claim, characterized in that the reaction is carried out in the presence of an organic solvent.
CH206550D 1936-12-24 1936-12-24 Process for the preparation of a new carbonic acid derivative. CH206550A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH206550T 1936-12-24

Publications (1)

Publication Number Publication Date
CH206550A true CH206550A (en) 1939-08-15

Family

ID=4445112

Family Applications (1)

Application Number Title Priority Date Filing Date
CH206550D CH206550A (en) 1936-12-24 1936-12-24 Process for the preparation of a new carbonic acid derivative.

Country Status (1)

Country Link
CH (1) CH206550A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2708651A (en) * 1955-01-07 1955-05-17 Pfizer & Co C Water-soluble esters of pregnanolones

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2708651A (en) * 1955-01-07 1955-05-17 Pfizer & Co C Water-soluble esters of pregnanolones

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