CH292799A - Process for the preparation of 1-phenyl-2,3-dimethyl-4-isopropylamino-5-pyrazolone. - Google Patents

Process for the preparation of 1-phenyl-2,3-dimethyl-4-isopropylamino-5-pyrazolone.

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Publication number
CH292799A
CH292799A CH292799DA CH292799A CH 292799 A CH292799 A CH 292799A CH 292799D A CH292799D A CH 292799DA CH 292799 A CH292799 A CH 292799A
Authority
CH
Switzerland
Prior art keywords
pyrazolone
dimethyl
phenyl
isopropylamino
preparation
Prior art date
Application number
Other languages
German (de)
Inventor
Farbwerke Hoechst Vor Bruening
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of CH292799A publication Critical patent/CH292799A/en

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Description

  

  Verfahren zur Herstellung von     1-Phenyl-2,3-dimethyl-4-isopropylamino-5-pyrazolon.            Gegenstand    der vorliegenden Erfindung  ist ein Verfahren zur     Herstellung    von     1-Phe-          iivl    - 2,3 -     dimethyl    - 4-     isopropylamino-5-pyrazo-          lon,    das dadurch gekennzeichnet ist, dass man       1-1'lienyl-2,3-dimethyl-4-amino-5-pyrazolon    mit       Aceton    in Gegenwart von amalgamiertem  Zink und Säure bei erhöhter Temperatur um  setzt.  



  Das nach dem     vorliegenden    Verfahren     er-          lialtene        1-Pheii#,1-2,0'-dimeth-,y-1-4-isopropyl-          z        anAno        -5-pyrazolon        ist        bereits        bekannt.        Es        soll     als Zwischenprodukt verwendet werden.

      <I>Beispiel 1:</I>    20 Gewichtsteile     1-Phenyl-2,3-dimethyl-4-          amino-5-pyrazolon    werden mit 30 Gewichts  teilen amalgamiertem Zink, 24 Gewichtsteilen       _leeton        und    120     Volumteilen    verdünnter Salz-    säure (1 :1) vier Stunden am     Rückfluss    er  hitzt.

   Dann wird mit konzentrierter Natron  lauge     alkalisch    gemacht und     ausgeäthert.     Nach Trocknen und Verdampfen des Äthers  erhält man 23,5 Gewichtsteile fast reines       1-Phenyl-2,3        -dimethyl        -4-isopropylamino    -     5-          pyrazolon    vom Schmelzpunkt 78 , das durch       Umkristallisieren    aus Essigester farblose Kri  stalle vom Schmelzpunkt 80  ergibt.



  Process for the preparation of 1-phenyl-2,3-dimethyl-4-isopropylamino-5-pyrazolone. The present invention relates to a process for the preparation of 1-phenyl-2,3-dimethyl-4-isopropylamino-5-pyrazolone, which is characterized in that 1-1'lienyl-2,3-dimethyl -4-amino-5-pyrazolone with acetone in the presence of amalgamated zinc and acid at elevated temperature.



  The 1-Pheii #, 1-2,0'-dimeth-, y-1-4-isopropyl-z anAno -5-pyrazolone obtained by the present process is already known. It is intended to be used as an intermediate.

      <I> Example 1: </I> 20 parts by weight of 1-phenyl-2,3-dimethyl-4-amino-5-pyrazolone are mixed with 30 parts by weight of amalgamated zinc, 24 parts by weight of leeton and 120 parts by volume of dilute hydrochloric acid (1: 1) He refluxed for four hours.

   Then it is made alkaline with concentrated sodium hydroxide solution and etherified. After drying and evaporation of the ether, 23.5 parts by weight of almost pure 1-phenyl-2,3-dimethyl -4-isopropylamino-5-pyrazolone with a melting point of 78, which by recrystallization from ethyl acetate gives colorless crystals with a melting point of 80.

Claims (1)

PATENTANSPRUCH Verfahren zur Herstellung von 1-Phenyl- 2,3-dimet.hyl-4-isopropylamino-5-pyrazolon, da durch gekennzeichnet, dass man 1-Phenyl-2,3- dimethyl-4-amino-5-pyrazolon mit Aceton in Gegenwart von amalgamiertem Zink und Säure bei erhöhter Temperatur umsetzt. PATENT CLAIM Process for the preparation of 1-phenyl-2,3-dimethyl-4-isopropylamino-5-pyrazolone, characterized in that 1-phenyl-2,3-dimethyl-4-amino-5-pyrazolone with acetone in the presence of amalgamated zinc and acid at elevated temperature.
CH292799D 1950-03-06 1951-02-13 Process for the preparation of 1-phenyl-2,3-dimethyl-4-isopropylamino-5-pyrazolone. CH292799A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE292799X 1950-03-06

Publications (1)

Publication Number Publication Date
CH292799A true CH292799A (en) 1953-08-31

Family

ID=6075445

Family Applications (1)

Application Number Title Priority Date Filing Date
CH292799D CH292799A (en) 1950-03-06 1951-02-13 Process for the preparation of 1-phenyl-2,3-dimethyl-4-isopropylamino-5-pyrazolone.

Country Status (1)

Country Link
CH (1) CH292799A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2864413A (en) * 1956-02-21 1958-12-16 Johnson Mfg Co Gang saw

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2864413A (en) * 1956-02-21 1958-12-16 Johnson Mfg Co Gang saw

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