CH269073A - Process for the preparation of a basic ether of a p-substituted benzhydrol. - Google Patents

Process for the preparation of a basic ether of a p-substituted benzhydrol.

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Publication number
CH269073A
CH269073A CH269073DA CH269073A CH 269073 A CH269073 A CH 269073A CH 269073D A CH269073D A CH 269073DA CH 269073 A CH269073 A CH 269073A
Authority
CH
Switzerland
Prior art keywords
ether
preparation
chloro
basic ether
benzhydrol
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH269073A publication Critical patent/CH269073A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

  

  Verfahren zur Herstellung eines basischen Äthers eines     p-substituierten        Benzhydrols.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung eines basischen  Äthers eines     p-substituierten        Benzhydrols.    Das  Verfahren ist dadurch gekennzeichnet, dass  man einen     p-Chlor-benzhydryl-        (ss-halogen-          äthyl)-äther    mit     Dimethylamin    umsetzt.  



  Die erhaltene neue     Verbindung,    der     p-          Chlor    -     benzhydryl    -     dimethylaminoäthyl-äther,     siedet unter 0,02 mm Druck bei     134-137 .    Sie  soll therapeutische Verwendung finden.  



  <I>Beispiel:</I>  32,3 Teile     p-Chlor-benzhydryl-        (ss-chlor-          äthyl)-äther,    erhältlich durch Umsetzen von       p-Chlor-benzhydryl-bromid    und     Äthylenchlor-          hydrin,    werden mit 10 Teilen     Dimethylamin          (100o/oig)    in einem     Einschlussrohr    4 Stunden  auf 1l0  erhitzt. Darauf versetzt man das  Reaktionsprodukt mit Wasser und säuert in  der Kälte     mit    Essigsäure an.

   Die durch Aus  schütteln mit Äther von     Neutralprodukten     befreite essigsaure Lösung wird kalt mit     konz.       Natronlauge     alkalisch    gestellt und     ausge-          äthert.    Durch Eindampfen     wird    der     p-Chlor-          benzhydryl    -     dimethylaminoäthyl    -     äther    vom  Siedepunkt 134 bis 137  unter 0,02 mm Druck  erhalten.



  Process for the preparation of a basic ether of a p-substituted benzhydrol. The subject of the present patent is a process for the preparation of a basic ether of a p-substituted benzhydrol. The process is characterized in that a p-chloro-benzhydryl (s-halo-ethyl) ether is reacted with dimethylamine.



  The new compound obtained, the p-chloro-benzhydryl-dimethylaminoethyl ether, boils under 0.02 mm pressure at 134-137. It should find therapeutic use.



  <I> Example: </I> 32.3 parts of p-chloro-benzhydryl (ss-chloroethyl) ether, obtainable by reacting p-chloro-benzhydryl bromide and ethylene chlorohydrin, are mixed with 10 parts of dimethylamine (100%) heated to 10 for 4 hours in an inclusion tube. The reaction product is then mixed with water and acidified with acetic acid in the cold.

   The acetic acid solution freed from neutral products by shaking with ether is cold with conc. Sodium hydroxide solution made alkaline and etherified. The p-chlorobenzhydryl dimethylaminoethyl ether with a boiling point of 134 to 137 is obtained by evaporation under 0.02 mm pressure.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines basischen Äthers eines p-substituierten Benzhydrols, da durch gekennzeichnet, dass man einen p-Chlor- benzhydryl-(ss-halogen-äthyl)-äther mit Di- methylamin umsetzt. Die erhaltene neue Verbindung, der p Chlor-benzhydryl-dimethylaminoäthyl-äther, siedet unter 0,02 mm Druck bei 134 bis 137 . PATENT CLAIM: Process for the production of a basic ether of a p-substituted benzhydrol, characterized in that a p-chlorobenzhydryl (ss-haloethyl) ether is reacted with dimethylamine. The new compound obtained, the p chloro-benzhydryl-dimethylaminoethyl-ether, boils at 134 to 137 under 0.02 mm pressure. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man p-Chlor-benzhydryl- (ss-chlor-äthyl)-äther mit Dimethylamin iun- setzt. SUBSTANTIAL CLAIM: Process according to patent claim, characterized in that p-chloro-benzhydryl (s-chloro-ethyl) ether is iun with dimethylamine.
CH269073D 1947-09-12 1947-09-12 Process for the preparation of a basic ether of a p-substituted benzhydrol. CH269073A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH264135T 1947-09-12
CH269073T 1947-09-12

Publications (1)

Publication Number Publication Date
CH269073A true CH269073A (en) 1950-06-15

Family

ID=25730724

Family Applications (1)

Application Number Title Priority Date Filing Date
CH269073D CH269073A (en) 1947-09-12 1947-09-12 Process for the preparation of a basic ether of a p-substituted benzhydrol.

Country Status (1)

Country Link
CH (1) CH269073A (en)

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