CH269072A - Process for the preparation of a basic ether of a p-substituted benzhydrol. - Google Patents

Process for the preparation of a basic ether of a p-substituted benzhydrol.

Info

Publication number
CH269072A
CH269072A CH269072DA CH269072A CH 269072 A CH269072 A CH 269072A CH 269072D A CH269072D A CH 269072DA CH 269072 A CH269072 A CH 269072A
Authority
CH
Switzerland
Prior art keywords
ether
preparation
benzhydryl
methyl
benzhydrol
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH269072A publication Critical patent/CH269072A/en

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung eines basischen Äthers eines     p-substituierten        Benzhydrole.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung eines basischen  Äthers eines     p-substituierten        Benzhydrols.    Das  Verfahren ist dadurch gekennzeichnet, dass  man einen     p-Methyl-benzhydryl-(p-halogen-          äthyl)-äther    mit     Dimethylamin    umsetzt.  



  Die erhaltene neue Verbindung, der p  Methyl-benzhydryl-dimethylaminoäthyl-äther,  siedet unter 0,1 mm Druck bei 143 0. Sie soll  therapeutische Verwendung finden.  



  <I>Beispiel:</I>  30,2 Teile     *        p-Methyl-benzhydryl-(@-chlor-          äthyl)-äther,    erhältlich durch Umsetzen von       p-Methyl-benzhydryl-bromid    und     Äthylen-          chlorhydrin,    werden mit 10 Teilen     Dimethyl-          amin    (100      /oig)    in einem     Einschlussrohr     4 Stunden auf 110 0 erhitzt. Darauf versetzt  man das Reaktionsprodukt mit Wasser und  säuert in der Kälte mit Essigsäure an.

   Die  durch Ausschütteln mit Äther von Neutral  produkten befreite     essigsaure    Lösung wird    kalt mit     konz.    Natronlauge alkalisch gestellt  und     ausgeäthert.    Durch Eindampfen wird der  p -     Methyl    -     benzhydryl    -     dimethylaminoäthyl        -          äther    vom Siedepunkt 1431 unter 0,1 mm  Druck erhalten.



  Process for the preparation of a basic ether of a p-substituted benzhydrol. The subject of the present patent is a process for the preparation of a basic ether of a p-substituted benzhydrol. The process is characterized in that a p-methylbenzhydryl (p-haloethyl) ether is reacted with dimethylamine.



  The new compound obtained, the p methyl benzhydryl dimethylaminoethyl ether, boils at 143 0 under 0.1 mm pressure. It is said to find therapeutic use.



  <I> Example: </I> 30.2 parts of * p-methyl-benzhydryl - (@ - chloro-ethyl) -ether, obtainable by reacting p-methyl-benzhydryl-bromide and ethylene-chlorohydrin, are mixed with 10 parts Dimethylamine (100%) heated to 110 ° for 4 hours in an inclusion tube. The reaction product is then mixed with water and acidified with acetic acid in the cold.

   The acetic acid solution, freed from neutral products by shaking with ether, is cold with conc. Sodium hydroxide solution made alkaline and etherified. The p-methyl-benzhydryl-dimethylaminoethyl-ether of boiling point 1431 is obtained by evaporation under 0.1 mm pressure.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines basischen Äthers eines p-substituierten Benzhydrols, dadurch gekennzeichnet, dass man einen p-Methyl-benzhydryl-(ss-halogen-äthyl)-äther mit Dimethylamin umsetzt. Die erhaltene neue Verbindung, der p Methyl-benzhydryl-dimethylaminoäthyl-äther; siedet unter 0,1 mm Druck bei 1430. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man p-Methyl-benzhy- dryl-(@-chlor-äthyl)-äther mit Dimethylamin umsetzt. PATENT CLAIM: A process for the preparation of a basic ether of a p-substituted benzhydrol, characterized in that a p-methyl-benzhydryl (ss-halo-ethyl) ether is reacted with dimethylamine. The new compound obtained, the p methyl benzhydryl dimethylaminoethyl ether; boils under 0.1 mm pressure at 1430. SUBSTITUTE SHEET: Process according to patent claim, characterized in that p-methylbenzhy- dryl - (@ - chloroethyl) ether is reacted with dimethylamine.
CH269072D 1947-09-12 1947-09-12 Process for the preparation of a basic ether of a p-substituted benzhydrol. CH269072A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH264135T 1947-09-12
CH269072T 1947-09-12

Publications (1)

Publication Number Publication Date
CH269072A true CH269072A (en) 1950-06-15

Family

ID=25730723

Family Applications (1)

Application Number Title Priority Date Filing Date
CH269072D CH269072A (en) 1947-09-12 1947-09-12 Process for the preparation of a basic ether of a p-substituted benzhydrol.

Country Status (1)

Country Link
CH (1) CH269072A (en)

Similar Documents

Publication Publication Date Title
CH269072A (en) Process for the preparation of a basic ether of a p-substituted benzhydrol.
CH269073A (en) Process for the preparation of a basic ether of a p-substituted benzhydrol.
CH264135A (en) Process for the preparation of a basic ether of a p-substituted benzhydrol.
CH250806A (en) Process for the preparation of a new oxyhydrophenanthrene derivative.
CH256765A (en) Process for the production of a new half-ester.
CH217133A (en) Process for the production of a water-soluble, higher molecular weight, α-substituted benzylamine derivative.
CH178101A (en) Process for the production of a new textile auxiliary.
CH245679A (en) Process for the preparation of a 4-chloro-benzenesulfonamide.
CH240143A (en) Process for the preparation of a basic aralkyl ether.
CH240133A (en) Process for the preparation of a basic aralkyl ether.
CH250809A (en) Process for the preparation of a new oxyhydrophenanthrene derivative.
CH240379A (en) Process for the preparation of an acylated, aliphatic aminocarboxamide.
CH237513A (en) Process for the preparation of dimethylmalonic acid-bis-diethylamide.
CH269340A (en) Process for the representation of a basic ether.
CH252055A (en) Process for the production of a condensation product.
CH216303A (en) Process for the preparation of a new derivative of a heterocyclic compound.
CH201508A (en) Process for the preparation of a quaternary aminobenzylacylamine.
CH269422A (en) Process for the preparation of a basic ester.
CH242289A (en) Process for the preparation of a basic ester of a 1-aryl-cycloalkyl-1-carboxylic acid.
CH165405A (en) Process for the preparation of 2-oxy-3,5-diiodopyridine-6-carboxylic acid.
CH213253A (en) Process for the preparation of a new derivative of a heterocyclic compound.
CH217132A (en) Process for the production of a water-soluble, higher molecular weight, α-substituted benzylamine derivative.
CH187360A (en) Process for the preparation of a mixture of isomeric acyloctahydrofollicle hormones.
CH307878A (en) Process for the preparation of a bactericidal salicylanilide.
CH210959A (en) Process for the production of a new condensation product.