CH233731A - Process for the preparation of an aromatic carboxamide. - Google Patents

Process for the preparation of an aromatic carboxamide.

Info

Publication number
CH233731A
CH233731A CH233731DA CH233731A CH 233731 A CH233731 A CH 233731A CH 233731D A CH233731D A CH 233731DA CH 233731 A CH233731 A CH 233731A
Authority
CH
Switzerland
Prior art keywords
sep
preparation
phenyl
aromatic carboxamide
amino
Prior art date
Application number
Other languages
German (de)
Inventor
Ag Sandoz
Original Assignee
Ag Sandoz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag Sandoz filed Critical Ag Sandoz
Publication of CH233731A publication Critical patent/CH233731A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3544—Organic compounds containing hetero rings

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Zusatzpatent zum Hauptpatent Nr. 228988.    Verfahren zur Darstellung eines aromatischen     Carbonsäur        eamids.       Das vorliegende Patent     betrifft    ein Ver  fahren zur Darstellung des     1-Phenyl-2,3-,di-          methylpyra.zo@lo@ns        des,        2-Oxy-benzamid:

  s,    wel  ches dadurch     gekennzeichnet    ist, dass man       2-Acetoxy-benzoylchlo,rid    und     4-Amino-(1-          phenyl    - 2,3 -     dimethylpyrazolon        aufeinander          einwirken        lässt.     



  <I>Beispiel:</I>  5,3 g 4     -Amino    -     (1-phenyl    -     2,3-dimethyl-          pyrazolon)    werden     in    40     em3    Wasser     ,gelöst.     
EMI0001.0023     
  
EMI0001.0024     
  
    C"H1;03N, <SEP> Ber. <SEP> <B>C66,8; <SEP> H5,2; <SEP> N13,0%,</B>
<tb>  Gef. <SEP> <B>C66,9;</B> <SEP> H <SEP> ä,2; <SEP> N <SEP> 1.8,1 <SEP> %.

         Unter gutem Kühlen und lebhaftem Um  rühren werden im Laufe einer Stunde in  kleinen     Portionen    7,5     ,g        2--Aoeto.xy-benzoyl-          chlori,d        und    120     ema    n/1     Na0H        zugegeben.     Gegen das Ende der Reaktion wird erwärmt  und mit     10%iger        Sal@mäure        neutraliäert.     



  Das     Reaktionsprodukt    fällt     aus    und wird  durch wiederholtes     Umkristallis.ieren    aus Al  kohol     gereinigt.        Smp.    2l9  C. Es besitzt die       Formel       Die neue     Verbindung        soll    als     Ausgangsstoff     für die Herstellung von therapeutischen Pro-           dukten    und als     Konservierungsmittel        Ver-          wendung    finden.



  Additional patent to main patent No. 228988. Process for the preparation of an aromatic carboxamide. The present patent relates to a process for the preparation of 1-phenyl-2,3-, dimethylpyra.zo @ lo @ ns des, 2-oxy-benzamide:

  s, which is characterized in that 2-acetoxy-benzoylchloride and 4-amino- (1-phenyl - 2,3 - dimethylpyrazolone are allowed to act on one another.



  <I> Example: </I> 5.3 g of 4-amino - (1-phenyl - 2,3-dimethylpyrazolone) are dissolved in 40 cubic meters of water.
EMI0001.0023
  
EMI0001.0024
  
    C "H1; 03N, <SEP> Ber. <SEP> <B> C66.8; <SEP> H5.2; <SEP> N13.0%, </B>
<tb> Gef. <SEP> <B> C66,9; </B> <SEP> H <SEP> ä, 2; <SEP> N <SEP> 1.8,1 <SEP>%.

         With good cooling and vigorous stirring, 7.5 g of 2-aoeto.xy-benzoylchlori, d and 120 ema n / 1 NaOH are added in small portions over the course of an hour. Towards the end of the reaction, the mixture is heated and neutralized with 10% hydrochloric acid.



  The reaction product precipitates and is purified from alcohol by repeated recrystallization. Mp. 219 C. It has the formula The new compound is intended to be used as a starting material for the manufacture of therapeutic products and as a preservative.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung des 1-Phenyl- 2,3-,dimathylpyra.zolons des 2-Osy-benzamids, dadurch gekennzeichnet, dass man ?- Acetoxy- benzoylchlori,d und 4-Amino-(1-phenyl-?.3- dimethylpyrazrnlon) aufeinander einwirken üsst. Das neue Produkt besitzt den Smp. 219 C und die Formel EMI0002.0019 EMI0002.0020 CxaH170:,N:, <SEP> Ber. <SEP> <B>C66,8; PATENT CLAIM: Process for the preparation of the 1-phenyl-2,3-, dimathylpyra.zolons of 2-Osy-benzamide, characterized in that one? - Acetoxybenzoylchlori, d and 4-amino- (1-phenyl - ?. 3 - dimethylpyrazrnlon) interact. The new product has the melting point 219 C and the formula EMI0002.0019 EMI0002.0020 CxaH170:, N :, <SEP> Ber. <SEP> <B> C66.8; </B> <SEP> 115,2); <SEP> <B>N13,0%,</B> <tb> Gef. <SEP> <B>C66,9; <SEP> H5,2; <SEP> N13,1%.</B> Die neue Verbindung soll als Ausgangsstoff für die Herstellung von therapeutischen Pro dukten und al.s @onservierungs iitt-el Ver wendung finden. </B> <SEP> 115.2); <SEP> <B> N13.0%, </B> <tb> Found <SEP> <B> C66.9; <SEP> H5.2; <SEP> N13.1%. </B> The new compound is to be used as a starting material for the manufacture of therapeutic products and al.s @conservierungsiitt-el.
CH233731D 1942-04-17 1942-04-17 Process for the preparation of an aromatic carboxamide. CH233731A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH228933T 1942-04-17
CH233731T 1942-04-17

Publications (1)

Publication Number Publication Date
CH233731A true CH233731A (en) 1944-08-15

Family

ID=25727275

Family Applications (1)

Application Number Title Priority Date Filing Date
CH233731D CH233731A (en) 1942-04-17 1942-04-17 Process for the preparation of an aromatic carboxamide.

Country Status (1)

Country Link
CH (1) CH233731A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1195759B (en) * 1957-11-20 1965-07-01 Rer Nat Felix H Schmidt Dr Process for the preparation of 1-phenyl-2, 3-dimethyl-4- (salicoyl-oxyacetyl-amino) -pyrazolon- (5)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1195759B (en) * 1957-11-20 1965-07-01 Rer Nat Felix H Schmidt Dr Process for the preparation of 1-phenyl-2, 3-dimethyl-4- (salicoyl-oxyacetyl-amino) -pyrazolon- (5)

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