CH253640A - Process for the preparation of 2- (3 ', 5'-dibromo-salicoylamino) -thiazole. - Google Patents
Process for the preparation of 2- (3 ', 5'-dibromo-salicoylamino) -thiazole.Info
- Publication number
- CH253640A CH253640A CH253640DA CH253640A CH 253640 A CH253640 A CH 253640A CH 253640D A CH253640D A CH 253640DA CH 253640 A CH253640 A CH 253640A
- Authority
- CH
- Switzerland
- Prior art keywords
- thiazole
- dibromo
- salicoylamino
- preparation
- amino
- Prior art date
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Description
Verfahren zur Darstellung von 2-(3',5'-Dibrom-salicoylamino)-thiazol. Das vorliegende Patent betrifft ein Ver fahren zur Herstellung von 2-(3',5'-Dibrom- sa.licoylamino)-thiazol, welches dadurch ge l:ennzeichnet ist, da.ss man 3,5-Dibrom-sali- cv lsä urechlorid auf 2-Amino-thiazol einwir ken lässt.
<I>Beispiel:</I> 14,0 g 2-Amino-thiazol werden in einem Cierniseh von 30 cm' Chloroform und 14 eins Pyridin gelöst. Zu dieser Lösung gibt man unter Rühren 9,0 g 3,5-Dibrom-salicylsäure- chlorid, welches zuvor in 44 em3 Chloroform gelöst wurde.
Das Reaktionsgemisch -wird während 21/2 Stunden am Rückfluss gekocht und nachher abgekühlt. Der entstandene Niederschlag wird von der Reaktionsmischung abgetrennt, mit Wasser gut gewaschen und aus 300 cms Eisessig wiederholt umkristallisiert.
Die neue Verbindung besitzt die, Formel
EMI0001.0025
Sie hat den Smp. 260 C (korr.). Analyse: Bruttozusammensetzung C1oH,O.#N@SBr2. Ber. C 31,74; H 1,59; N 7,4 %.
Gef. <B>C31,9; H1,7; N7,3%.</B>
Process for the preparation of 2- (3 ', 5'-dibromo-salicoylamino) -thiazole. The present patent relates to a process for the production of 2- (3 ', 5'-dibromo- sa.licoylamino) -thiazole, which is characterized by the fact that 3,5-dibromosalicv isa ure chloride can act on 2-amino-thiazole.
<I> Example: </I> 14.0 g of 2-amino-thiazole are dissolved in a mixture of 30 cm 'of chloroform and 14% of pyridine. 9.0 g of 3,5-dibromosalicylic acid chloride, which had previously been dissolved in 44 cubic meters of chloroform, are added to this solution with stirring.
The reaction mixture is refluxed for 21/2 hours and then cooled. The resulting precipitate is separated off from the reaction mixture, washed well with water and repeatedly recrystallized from 300 cms of glacial acetic acid.
The new compound has the formula
EMI0001.0025
It has a melting point of 260 C (corr.). Analysis: gross composition C1oH, O. # N @ SBr2. Ber. C 31.74; H 1.59; N 7.4%.
Found <B> C31.9; H1.7; N7.3%. </B>
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH246984T | 1945-12-07 | ||
| CH253640T | 1945-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH253640A true CH253640A (en) | 1948-03-15 |
Family
ID=25729149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH253640D CH253640A (en) | 1945-12-07 | 1945-12-07 | Process for the preparation of 2- (3 ', 5'-dibromo-salicoylamino) -thiazole. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH253640A (en) |
-
1945
- 1945-12-07 CH CH253640D patent/CH253640A/en unknown
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