CH233739A - Process for the preparation of an aromatic carboxamide. - Google Patents

Process for the preparation of an aromatic carboxamide.

Info

Publication number
CH233739A
CH233739A CH233739DA CH233739A CH 233739 A CH233739 A CH 233739A CH 233739D A CH233739D A CH 233739DA CH 233739 A CH233739 A CH 233739A
Authority
CH
Switzerland
Prior art keywords
sep
preparation
phenylacetylamino
aromatic carboxamide
aminothiazole
Prior art date
Application number
Other languages
German (de)
Inventor
Ag Sandoz
Original Assignee
Ag Sandoz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag Sandoz filed Critical Ag Sandoz
Publication of CH233739A publication Critical patent/CH233739A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3544—Organic compounds containing hetero rings

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Zusatzpatent zum     Hauptpatent    Nr.     228933.       Verfahren zur Darstellung eines aromatischen     Carbonsäureamids.       Das vorliegende Patent betrifft ein Ver  fahren zur Darstellung von     2-Phenylacetyl-          amino-thi.azol,    welches dadurch     gekennzeich-          net        isst,        :dass        man        Phenylacetylchlo@rid    und       2-Amino-thiazoil    aufeinander einwirken     lässt.       <I>Beispiel:

  </I>    22 g     2-Amnno-thiazol,    gelöst in einem       Gemisch    von 100 cm' reinem     Dioxan    und  100 cm' Äther, werden bei 5-10      langsam    in  kleinen Portionen mit einer Lösung von  14,4 g     Phenylacetylohlorid    in 200 cm'     Ather     
EMI0001.0020     
         Analysenergebnisse     
EMI0001.0022     
  
    Für <SEP> C11H"0N <SEP> :S <SEP> Ber. <SEP> N <SEP> =12,84 <SEP> %,
<tb>  0 <SEP> Gef. <SEP> N=12,91%;

  12,94%       Die neue     Verbindung    soll als Ausgangs  material für die     Herstellung    von therapeu-         versetzt.    Man     lässt    stehen und     trennt    den       Niederschlag    ab. Es wird zur     Entfernung     von     Amino-thiazolchilorhy.drat    mit warmem  Wasser     di,gerlort    und     nach    der     Filtration     noch feucht in     50%igem        Alko@hod    durch Zu  gabe von 2n     Na0H    gelöst.

   Die     filtrierte     Lösung wird     aufgewärmt    und     mit    Essigsäure  bis zum Verschwinden der     alkalischen    Reak  tion versetzt. Das 2 -     Phenyla.cetylamino        -          thazojl    kristallisiert aus Alkohol in weissen,  biegsamen Nadeln vom     !Sm,-p.        163-165 ;    sie  besitzt die Formel    tischen Produkten und als Konservierungs  mittel verwendet     werden:.  



  Additional patent to main patent No. 228933. Process for the preparation of an aromatic carboxamide. The present patent relates to a method for the preparation of 2-phenylacetylamino-thi.azole, which is characterized by eating: phenylacetylchloride and 2-aminothiazole are allowed to act on one another. <I> example:

  </I> 22 g of 2-amnno-thiazole, dissolved in a mixture of 100 cm 'of pure dioxane and 100 cm' of ether, are slowly mixed in small portions at 5-10 with a solution of 14.4 g of phenylacetyl chloride in 200 cm ' Ether
EMI0001.0020
         Analysis results
EMI0001.0022
  
    For <SEP> C11H "0N <SEP>: S <SEP> Ber. <SEP> N <SEP> = 12.84 <SEP>%,
<tb> 0 <SEP> found <SEP> N = 12.91%;

  12.94% The new compound is said to be used as the starting material for the manufacture of therapeu-offset. It is left to stand and the precipitate is separated off. To remove Amino-thiazolchilorhy.drat it is dyed, smoldered with warm water and after the filtration still moist in 50% Alko @ hod dissolved by adding 2N NaOH.

   The filtered solution is warmed up and acetic acid is added until the alkaline reaction disappears. The 2 - Phenyla.cetylamino - thazojl crystallizes from alcohol in white, flexible needles of! Sm, -p. 163-165; It owns the formula tables products and can be used as a preservative :.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von 2-Phenyl- acetylamino-thiazol, dadurch ,gekennzeichnet, dass man Phenylacetylehlorid und 2 Amino- thiazol aufeinander einwirken lässt. PATENT CLAIM: Process for the preparation of 2-phenylacetylamino-thiazole, characterized in that phenylacetyl chloride and 2-aminothiazole are allowed to act on one another. Die neue Verbindung stellt weisse, bieg same Nadeln vom Smp. 163-165 dar und besitzt die Formel EMI0002.0008 Die Analyse ergibt: EMI0002.0011 Für <SEP> C"I3"0N28 <SEP> Ber. <SEP> N <SEP> =12,84 <SEP> %, <tb> Gef.N=12,91 <SEP> % <SEP> ; <SEP> 12,94, ö. Das 2-Phenylacetylamino-thiazal soll als Ausgangsmaterial für die Herstellung von thera.peutisehen Produkten und als Konser- vierungsmittel Verwendung finden. The new compound represents white, flexible needles with a melting point of 163-165 and has the formula EMI0002.0008 The analysis shows: EMI0002.0011 For <SEP> C "I3" 0N28 <SEP> Ber. <SEP> N <SEP> = 12.84 <SEP>%, <tb> Found N = 12.91 <SEP>% <SEP>; <SEP> 12.94, ö. The 2-phenylacetylamino-thiazal is said to be used as a starting material for the manufacture of therapeutic products and as a preservative.
CH233739D 1942-04-17 1942-04-17 Process for the preparation of an aromatic carboxamide. CH233739A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH233739T 1942-04-17
CH228933T 1942-04-17

Publications (1)

Publication Number Publication Date
CH233739A true CH233739A (en) 1944-08-15

Family

ID=25727283

Family Applications (1)

Application Number Title Priority Date Filing Date
CH233739D CH233739A (en) 1942-04-17 1942-04-17 Process for the preparation of an aromatic carboxamide.

Country Status (1)

Country Link
CH (1) CH233739A (en)

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