CH199675A - Process for the preparation of chlorometaxylenol azophenylsulfonamide. - Google Patents

Process for the preparation of chlorometaxylenol azophenylsulfonamide.

Info

Publication number
CH199675A
CH199675A CH199675DA CH199675A CH 199675 A CH199675 A CH 199675A CH 199675D A CH199675D A CH 199675DA CH 199675 A CH199675 A CH 199675A
Authority
CH
Switzerland
Prior art keywords
chlorometaxylenol
preparation
azophenylsulfonamide
solution
red
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellschaft V Siegfried
Original Assignee
Vorm B Siegfried Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vorm B Siegfried Ag filed Critical Vorm B Siegfried Ag
Publication of CH199675A publication Critical patent/CH199675A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung von     ühlormetaaylenolazophenylsnlfonamid.       Es wurde gefunden, dass man zu einer  Verbindung mit     therapeutiseh        interessanten          baktericiden    Eigenschaften gelangen kann.  wenn die     Diazoverbindung    des     4-Aminoben-          zolsulfonamids        mit        Chlormetaxylenol    in Ge  genwart verdünnter     Alkalilauge    kuppelt.

   Die  bisher     unbekannte    Verbindung stellt ein  braunrotes Pulver dar, das     in    Lauge mit       kräftig    roter Farbe löslich ist,     und,das    durch       ITmlösen    in     alkalischer    Lösung und Fällen  mit Säure gereinigt werden kann.  



  <I>Beispiel:</I>  Man     @diazotiert    eine Lösung von 20,8 g  4 -     Aminoben.zolsulfonamidohlorhydrat    in  100     em@    Wasser und 15 am'     konzentrierter     Salzsäure mit einer     Nitritlösung    aus 6,9 g       Natriumnitrit    bei 4       C    und kuppelt mit einer    Lösung von 15,6g     Chlormetaxylenol    in über  schüssiger     verdünnter    Natronlauge. Durch  Ansäuern     wird    das     Chlormetaxylenolazophe-          nylsulfonamid    als     braunrotes    Pulver ausge  fällt.



  Process for the preparation of ühlormetaaylenolazophenylsnlfonamid. It has been found that a compound with therapeutically interesting bactericidal properties can be obtained. when the diazo compound of 4-aminobenzenesulphonamide couples with chlorometaxylenol in the presence of dilute alkali.

   The hitherto unknown compound is a brown-red powder that is soluble in lye with a strong red color, and that can be cleaned by dissolving IT in an alkaline solution and cases with acid.



  <I> Example: </I> A solution of 20.8 g of 4 - aminoben.zolsulfonamidohlorhydrat in 100 em @ water and 15 am 'of concentrated hydrochloric acid is @diazotized with a nitrite solution of 6.9 g of sodium nitrite at 4 C and coupled with a solution of 15.6 g of chlorometaxylenol in excess dilute sodium hydroxide solution. Acidification causes the chlorometaxylenolazophenylsulfonamide to precipitate as a brown-red powder.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von Chlor metaxylenolazophenylsulfonamid, daduTCüh ge kennzeichnet, daB man die Diazoverbindung des 4-Aminobenzodsulfonamids mit Chlor- metaxylenol in verdünnter Natronlauge kup pelt. Das neue Produkt stellt -ein braunrotes Kristallpulver .dar, das in alkalischer Lösung sich mit roter Farbe löst. PATENT CLAIM: Process for the preparation of chlorine metaxylenolazophenylsulphonamide, which is characterized by the fact that the diazo compound of 4-aminobenzodsulphonamide is coupled with chlorometaxylenol in dilute sodium hydroxide solution. The new product is a red-brown crystal powder that dissolves in an alkaline solution with a red color.
CH199675D 1937-04-15 1937-04-15 Process for the preparation of chlorometaxylenol azophenylsulfonamide. CH199675A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH190547T 1937-04-15
CH199675T 1937-04-15

Publications (1)

Publication Number Publication Date
CH199675A true CH199675A (en) 1938-08-31

Family

ID=25722004

Family Applications (1)

Application Number Title Priority Date Filing Date
CH199675D CH199675A (en) 1937-04-15 1937-04-15 Process for the preparation of chlorometaxylenol azophenylsulfonamide.

Country Status (1)

Country Link
CH (1) CH199675A (en)

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