CH233729A - Process for the preparation of an aromatic carboxamide. - Google Patents

Process for the preparation of an aromatic carboxamide.

Info

Publication number
CH233729A
CH233729A CH233729DA CH233729A CH 233729 A CH233729 A CH 233729A CH 233729D A CH233729D A CH 233729DA CH 233729 A CH233729 A CH 233729A
Authority
CH
Switzerland
Prior art keywords
sep
preparation
salicoyl
aromatic carboxamide
acid chloride
Prior art date
Application number
Other languages
German (de)
Inventor
Ag Sandoz
Original Assignee
Ag Sandoz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag Sandoz filed Critical Ag Sandoz
Publication of CH233729A publication Critical patent/CH233729A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3544—Organic compounds containing hetero rings

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Zusatzpatent zum     FIauptpatent    Nr. 228983.    Verfahren zur Darstellung eines aromatischen     Carbonsäureamids.            Das    vorliegende Patent     betrifft    ein Ver  fahren zur Darstellung von     Sa.licoyl-2-amino-          thi@azal,    welches dadurch gekennzeichnet ist,  ,dass man     2-A@minathiazol        und        Salicy        lsäure-          chlorid        aufeinander    einwirken lässt.

      <I>Beispiel:</I>    5     g        2-Aminothiazol    werden in     trookenem     Benzol gelöst und     tropfenweise    mit einer       benzolischen    Lösung von 9,5 g     Salicyls"iture-          chlo,rid    zur Reaktion gebracht. Die     benzolische     
EMI0001.0021     
  
EMI0001.0022     
  
    C1oH80:N,S <SEP> Be:r. <SEP> C <SEP> 54,5; <SEP> 11<B>3,7;</B> <SEP> N <SEP> 12,7 <SEP> %,
<tb>  Gef. <SEP> C <SEP> 54,8; <SEP> H <SEP> 4,0; <SEP> N <SEP> 12,7 <SEP> % <SEP> .

         Die     neue    Verbindung soll als Ausgangsstoff  für die Herstellung von     therapeutischen:    Pro  dukten und ;als     Konservierungsmittel        Ver-          ivendung    finden.

           Lösung        wird    vom entstandenen, in Benzol  schwer löslichen Reaktionsprodukt     aIgegos-          sen,    das     Reaktionsprodukt    in     verdünnter     Salzsäure     gelflst,    mit     überschüssigem    Ammo  niak     ausgefällt    und aus Alkohol fraktioniert       umkristallisiert.    Der in Alkohol leicht lösliche  Anteil wird     mehrmals    aus Alkohol um  kristallisiert.

   Das so erhaltene     S#alicoy1-2-          ninotliiazol    sintert bei 250  und schmilzt  <B>,</B>     a#r     unter     Braunfärbung    bei 257      (korr.).    Es be  sitzt die     Formel  



  Additional patent to main patent No. 228983. Process for the preparation of an aromatic carboxamide. The present patent relates to a process for the preparation of sa.licoyl-2-aminothi @ azal, which is characterized in that 2-a @ minathiazole and salicylic acid chloride are allowed to act on one another.

      <I> Example: </I> 5 g of 2-aminothiazole are dissolved in troublesome benzene and reacted dropwise with a benzene solution of 9.5 g of salicylic acid chloride. The benzene
EMI0001.0021
  
EMI0001.0022
  
    C1oH80: N, S <SEP> Be: r. <SEP> C <SEP> 54.5; <SEP> 11 <B> 3.7; </B> <SEP> N <SEP> 12.7 <SEP>%,
<tb> Found <SEP> C <SEP> 54.8; <SEP> H <SEP> 4.0; <SEP> N <SEP> 12.7 <SEP>% <SEP>.

         The new compound is to be used as a starting material for the manufacture of therapeutic products and as a preservative.

           The resulting reaction product, which is sparingly soluble in benzene, is poured into a solution, the reaction product is dissolved in dilute hydrochloric acid, precipitated with excess ammonia and fractionally recrystallized from alcohol. The portion that is easily soluble in alcohol is recrystallized several times from alcohol.

   The so obtained S # alicoy1-2-ninotliiazole sinters at 250 and melts <B>, </B> a # r with brown coloration at 257 (corr.). It has the formula

Claims (1)

PATENTANSPRUCH: Verfahren; zur Darstellung von Salicoyl-2- aminoithdazol, :dadurch gekennzeichnet, dass man 2-Amin-othia.zol und Salieylsäurechlorid aufeinander einwirken läss:t. Das Salicoyl-2=aminothiazol sintert bei 2506 und schmilzt unter Braunfärbun- :, l; PATENT CLAIM: Process; for the preparation of salicoyl-2-aminoithdazole,: characterized in that 2-amine-othia.zol and salieylic acid chloride are allowed to act on one another: t. The salicoyl-2 = aminothiazole sinters at 2506 and melts with a brown color:, l; ei <B>257'</B> (horr.). Es besitzt die Formel EMI0002.0005 EMI0002.0006 Cl"H,O_N <SEP> ,'S <SEP> Ber. <SEP> C <SEP> 54,5; <SEP> <B>113,7;</B> <SEP> N <SEP> <B>1217</B> <SEP> Gef. <SEP> C <SEP> 54,3; <SEP> <B>1-1</B>4,0; <SEP> N <SEP> 12,7 <SEP> ö. EMI0002.0007 Die <SEP> neue <SEP> Verhindung <SEP> soll <SEP> als <SEP> Ausgangsstoff <tb> für <SEP> die <SEP> Verstellung <SEP> von <SEP> therapeutisehen <SEP> Pro ilia:lrteii <SEP> mid <SEP> als <SEP> @iozi@crvierungmittel <SEP> @er mndung; <SEP> finden. ei <B> 257 '</B> (horr.). It has the formula EMI0002.0005 EMI0002.0006 Cl "H, O_N <SEP>, 'S <SEP> Ber. <SEP> C <SEP> 54.5; <SEP> <B> 113.7; </B> <SEP> N <SEP> <B > 1217 </B> <SEP> Found <SEP> C <SEP> 54.3; <SEP> <B> 1-1 </B> 4.0; <SEP> N <SEP> 12.7 < SEP> ö. EMI0002.0007 The <SEP> new <SEP> connection <SEP> should <SEP> as a <SEP> starting material <tb> for <SEP> the <SEP> adjustment <SEP> of <SEP> therapeutic <SEP> Pro ilia: lrteii <SEP> mid <SEP> as <SEP> @ iozi @ crvierungmittel <SEP> @er mndung; Find <SEP>.
CH233729D 1942-04-17 1942-04-17 Process for the preparation of an aromatic carboxamide. CH233729A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH233729T 1942-04-17
CH228933T 1942-04-17

Publications (1)

Publication Number Publication Date
CH233729A true CH233729A (en) 1944-08-15

Family

ID=25727273

Family Applications (1)

Application Number Title Priority Date Filing Date
CH233729D CH233729A (en) 1942-04-17 1942-04-17 Process for the preparation of an aromatic carboxamide.

Country Status (1)

Country Link
CH (1) CH233729A (en)

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