CH137098A - Process for N-alkylation with an aminoalkyl halide. - Google Patents
Process for N-alkylation with an aminoalkyl halide.Info
- Publication number
- CH137098A CH137098A CH137098DA CH137098A CH 137098 A CH137098 A CH 137098A CH 137098D A CH137098D A CH 137098DA CH 137098 A CH137098 A CH 137098A
- Authority
- CH
- Switzerland
- Prior art keywords
- alkylation
- aminoalkyl halide
- aniline
- halide
- aminoalkyl
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur X-Alkyllerung mit einem Amino.ilkylhalogenid. Vorliegende Erfindung bezieht sich auf die Darstellung einer monoalkylierten Base von der Formel
EMI0001.0004
die als Pharmazeuticum und als Zwischen produkt zu solchen verwendet werden kann. Die Herstellung geschieht derart. dass man Anilin auf Diätylamiiioäthylehlorid-Halogen- hydrat einwirken lässt. Die freie Base ist ein farbloses<B>Öl</B> und siedet bei 121-1220C unter<B>5</B> mm Druck.
<I>Beispiel:</I> <B>260</B> (;ewichtsteile Anilin werden mit <B>171</B> Gewichtsteilen Diäthylaminoäthylehlorid- Ohlorhydrat während<B>8-10</B> Stunden bei <B>100-110 '</B> verschmolzen. Die Schmelze wird in Wasser aufgenommen, mit Pottasche alka lisch gemacht und die freie Base in wenig Äther oder Benzol gelöst. Nach'Trocknen über Pottasche wird zur Trennung von über schüssigem Anilin fraktioniert destilliert und dabei die monoalkylierte Base als farbloses <B>Öl</B> vom Kp. 121-1221 bei<B>5</B> mm Druck. erhalten.
Process for X-alkylation with an amino-alkyl halide. The present invention relates to the preparation of a monoalkylated base of the formula
EMI0001.0004
which can be used as a pharmaceutical and as an intermediate to such. The production happens like this. that aniline is allowed to act on diethylamine ethyl chloride halohydrate. The free base is a colorless <B> oil </B> and boils at 121-1220C under <B> 5 </B> mm pressure.
<I> Example: </I> <B> 260 </B> (; parts by weight of aniline are mixed with <B> 171 </B> parts by weight of diethylaminoethyl chloride chlorohydrate for <B> 8-10 </B> hours at <B > 100-110 '</B>. The melt is taken up in water, made alkaline with potash and the free base is dissolved in a little ether or benzene. After drying over potash, it is fractionally distilled to separate excess aniline the monoalkylated base was obtained as a colorless <B> oil </B> with bp 121-1221 at <B> 5 </B> mm pressure.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE137098X | 1927-01-25 | ||
| CH134094T | 1928-01-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH137098A true CH137098A (en) | 1929-12-15 |
Family
ID=25712224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH137098D CH137098A (en) | 1927-01-25 | 1928-01-12 | Process for N-alkylation with an aminoalkyl halide. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH137098A (en) |
-
1928
- 1928-01-12 CH CH137098D patent/CH137098A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CH137098A (en) | Process for N-alkylation with an aminoalkyl halide. | |
| CH138199A (en) | Process for N-alkylation with an aminoalkyl halide. | |
| CH218517A (en) | Process for the preparation of 1-methyl-4-phenyl-piperidyl-4-isopropyl-ketone. | |
| DE494320C (en) | Process for the preparation of isopropyl-n-butylmalonic ester | |
| CH194997A (en) | Process for the preparation of N- (γ-diethylaminopropyl) -5-amino-m-phenanthroline. | |
| CH138200A (en) | Process for N-alkylation with an aminoalkyl halide. | |
| AT163167B (en) | Process for the preparation of basic esters and amides of 1-aryl-cycloalkyl-1-carboxylic acids | |
| CH137677A (en) | Process for the preparation of a basic phenol alkyl ether. | |
| CH156442A (en) | Process for the preparation of a derivative of 3-nitro-4-oxybenzamide. | |
| CH136186A (en) | Process for the preparation of a basic phenol alkyl ether. | |
| CH333078A (en) | Process for the production of new anesthetic agents | |
| CH175234A (en) | Process for the preparation of 4-amino-3-ethoxy-4'-methoxy-diphenylamine. | |
| CH239754A (en) | Process for the preparation of a, y-dioxy-B, B-dimethyl-butyric acid- (3'-oxypropyl) -amide. | |
| CH210961A (en) | Process for the production of a new condensation product. | |
| CH161978A (en) | Process for the preparation of 4-butylaminobenzoic acid-B-dimethylaminoethyl ester. | |
| CH117493A (en) | Process for the preparation of p-N-B-methoxyethylaminobenzoic acid-B-piperidinoethyl ester. | |
| CH138198A (en) | Process for N-alkylation with an aminoalkyl halide. | |
| CH222484A (en) | Process for the preparation of 1-methyl-4-phenyl-piperidyl-4-propyl-ketone. | |
| CH144475A (en) | Process for obtaining a basic product from a stearoimido ether. | |
| CH194683A (en) | Process for the preparation of sulfanilic acid 2-methyl-5-aminoanilide. | |
| CH137676A (en) | Process for the preparation of a basic phenol alkyl ether. | |
| CH307890A (en) | Process for the preparation of a bactericidal salicylanilide. | |
| CH208132A (en) | Process for the production of a new, nitrogen-containing organic compound. | |
| CH125832A (en) | Process for the preparation of diethylaminoethyl-8-aminoquinoline. | |
| CH154173A (en) | Process for the preparation of 5,6-dimethoxy-8-aminoquinoline. |