CH138200A - Process for N-alkylation with an aminoalkyl halide. - Google Patents

Process for N-alkylation with an aminoalkyl halide.

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Publication number
CH138200A
CH138200A CH138200DA CH138200A CH 138200 A CH138200 A CH 138200A CH 138200D A CH138200D A CH 138200DA CH 138200 A CH138200 A CH 138200A
Authority
CH
Switzerland
Prior art keywords
sep
alkylation
aminoalkyl halide
chloropropane
base
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH138200A publication Critical patent/CH138200A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

      Verfahren    zur     N-Allzylierung        finit    einem     Aininoalltyllialogeiiid.       Vorliegende Erfindung bezieht sich auf  die Darstellung einer     monoalkylierten        Base.     von der Formel:  
EMI0001.0007     
    die als Pharmazeutikum und als Zwischen  produkt zu solchem verwendet werden kann.

    Die Herstellung geschieht derart,     da.B    man       8-Aminochinolin    auf     halogenwasserstoffsau-          res        a-N-Piperidyl-ss-oxy-y-clilorpropan    ein  wirken     lä.Bt    und die durch Alkalien frei  gemachte Base reinigt. Die freie Base ist  c -in hellgelbes Öl vom     Siedepunkt    212-213   C  unter 1 mm Druck.

      <I>Beispiel:</I>  144 Gewichtsteile 8-     Aminochinolin    wer  den mit 214     Gewichtsteilen        chlorwasserstoff-          saurem        a-N-Piperidyl-,8-oxy-y-chlo.rpropan     acht Stunden bei 120-180   C verschmolzen.  Die Schmelze wird' in     Wasser    aufgenommen,  mit Pottasche alkalisch gemacht und die  freie Base in wenig Äther oder Benzol ge  löst.

   Nach dem     Trocknen    über Pottasche  wird zur Trennung von überschüssigem     8-          Aminochinolin        fraktioniert        destilliert    und  dabei die     monoa.lkylierte    Base als hellgelbes  Öl vom Siedepunkt 212-213   C bei 1 mm  Druck     erhalten.  



      Process for the N-allzylation finitely with an Aininoalltyllialogeiiid. The present invention relates to the preparation of a monoalkylated base. from the formula:
EMI0001.0007
    which can be used as a pharmaceutical and as an intermediate to such.

    The production takes place in such a way that 8-aminoquinoline is allowed to act on a-N-piperidyl-ss-oxy-y-chloropropane and the base released by alkalis is purified. The free base is c - in a light yellow oil with a boiling point of 212-213 C under 1 mm pressure.

      <I> Example: </I> 144 parts by weight of 8-aminoquinoline are fused to 214 parts by weight of a-N-piperidyl-, 8-oxy-y-chloropropane, hydrogen chloride, at 120-180 ° C. for eight hours. The melt is taken up in water, made alkaline with potash and the free base is dissolved in a little ether or benzene.

   After drying over potash, excess 8-aminoquinoline is separated by fractional distillation and the monoalkylated base is obtained as a light yellow oil with a boiling point of 212-213 ° C. at 1 mm pressure.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer als Pharmazeutikum und als Zwisehenprodukt hierzu verwendbaren Verbindung von der Formel EMI0002.0001 EMI0002.0002 dadurch <SEP> gekennzeichnet, <SEP> dass <SEP> man <SEP> 8-Amino chinolin <SEP> auf <SEP> halogenwasserstoffsaures <SEP> a-IN Fiperidy <SEP> 1-ss-o@:cy-y-chlorpropan <SEP> einwirken <SEP> lässi <tb> und <SEP> die <SEP> durch <SEP> Alkalien <SEP> freigemachte <SEP> Base <tb> reinig. <SEP> Die <SEP> so <SEP> erhaltene <SEP> Substanz <SEP> ist <SEP> ein <tb> hellgelbes <SEP> Öl <SEP> und <SEP> siedet <SEP> bei <SEP> <B>212-213'</B> <SEP> C <tb> unter <SEP> 1 <SEP> mm <SEP> Druck. PATENT CLAIM: Process for the production of a compound of the formula which can be used as a pharmaceutical and as an intermediate product EMI0002.0001 EMI0002.0002 characterized by <SEP>, <SEP> that <SEP> one <SEP> 8-amino quinoline <SEP> on <SEP> hydrohalic acid <SEP> a-IN Fiperidy <SEP> 1-ss-o @: cy-y- chloropropane <SEP> take effect <SEP> lässi <tb> and <SEP> the <SEP> <SEP> base freed by <SEP> alkalis <SEP> <tb> clean. <SEP> The <SEP> so <SEP> obtained <SEP> substance <SEP> is <SEP> a <tb> light yellow <SEP> oil <SEP> and <SEP> boils <SEP> at <SEP> <B> 212-213 '</B> <SEP> C <tb> under <SEP> 1 <SEP> mm <SEP> print.
CH138200D 1927-01-25 1928-01-12 Process for N-alkylation with an aminoalkyl halide. CH138200A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE138200X 1927-01-25
CH134094T 1928-01-12

Publications (1)

Publication Number Publication Date
CH138200A true CH138200A (en) 1930-02-15

Family

ID=25712227

Family Applications (1)

Application Number Title Priority Date Filing Date
CH138200D CH138200A (en) 1927-01-25 1928-01-12 Process for N-alkylation with an aminoalkyl halide.

Country Status (1)

Country Link
CH (1) CH138200A (en)

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