CH339624A - Process for the preparation of a drug compound - Google Patents

Process for the preparation of a drug compound

Info

Publication number
CH339624A
CH339624A CH339624DA CH339624A CH 339624 A CH339624 A CH 339624A CH 339624D A CH339624D A CH 339624DA CH 339624 A CH339624 A CH 339624A
Authority
CH
Switzerland
Prior art keywords
preparation
drug compound
parts
acid
compound
Prior art date
Application number
Other languages
German (de)
Inventor
Ciotto Angelo
Peter Dipl Ing Chem Geistlich
Original Assignee
Geistlich Soehne Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geistlich Soehne Ag filed Critical Geistlich Soehne Ag
Publication of CH339624A publication Critical patent/CH339624A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

   <Desc/Clms Page number 1> 
    Verfahren   zur Herstellung einer    als      Arzneimittel   dienenden Verbindung Gegenstand des vorliegenden Patentes ist ein Verfahren zur Herstellung einer als Arzneimittel dienenden Verbindung, dadurch gekennzeichnet, dass man das    Isonicotinsäurehydrazon   des    3,4-Dimethoxy-      benzaldehydes      (3,4-Dimethoxy-l-benzyliden-isonico-      tinsäurehydrazon)   und    p-Amino-salicylsäure   in einem Lösungsmittel aufeinander einwirken lässt. 



  Die neue Verbindung soll als Pharmazeutikum für die Behandlung der Tuberkulose Verwendung finden. 



  Beispiel 1 285 Teile    Isonicotinsäurehydrazon   des    3,4-Di-      methoxy-benzaldehydes   werden in 2000 Teilen 0,5n Salzsäure gelöst und mit einer Lösung von 175 Teilen    p-amino-salicylsaurem   Na in 2000 Teilen Wasser versetzt. Es entsteht ein    eigelbfarbener   Niederschlag. Die neue Verbindung schmilzt bei 68  unter Zersetzung. 



  Beispiel 2 285    Teile      Isonicotinsäurehydrazon   des    3,4-Di-      methoxy-benzaldehydes   werden zusammen mit 156 Teilen    p-Aminosalicylsäure   in alkalischer, wässriger Lösung gelöst. Durch    Ansäuern   der Lösung mit einer Mineralsäure fällt die eigelb gefärbte Verbindung aus.    Smp.   68  (unter Zersetzung).



   <Desc / Clms Page number 1>
    Process for the preparation of a compound serving as a medicament The subject of the present patent is a process for the preparation of a compound serving as a medicament, characterized in that the isonicotinic acid hydrazone of 3,4-dimethoxy-benzaldehyde (3,4-dimethoxy-1-benzylidene-isonico - tinsäurehydrazone) and p-amino-salicylic acid can act on each other in a solvent.



  The new compound is said to be used as a pharmaceutical for the treatment of tuberculosis.



  Example 1 285 parts of 3,4-dimethoxybenzaldehyde isonicotinic acid hydrazone are dissolved in 2000 parts of 0.5N hydrochloric acid, and a solution of 175 parts of p-aminosalicylic acid Na in 2000 parts of water is added. An egg-yellow-colored precipitate forms. The new compound melts at 68 with decomposition.



  Example 2 285 parts of 3,4-dimethoxybenzaldehyde isonicotinic acid hydrazone are dissolved in alkaline, aqueous solution together with 156 parts of p-aminosalicylic acid. When the solution is acidified with a mineral acid, the egg-yellow colored compound precipitates. M.p. 68 (with decomposition).

Claims (1)

PATENTANSPRUCH Verfahren zur Herstellung einer als Arzneimittel dienenden Verbindung, dadurch gekennzeichnet, dass man das Isonicotinsäurehydrazon des 3,4-Dimethoxy- benzaldehydes und p-Amino-salicylsäure in einem Lösungsmittel aufeinander einwirken lässt. PATENT CLAIM Process for the preparation of a compound serving as a medicament, characterized in that the isonicotinic acid hydrazone of 3,4-dimethoxybenzaldehyde and p-amino-salicylic acid are allowed to act on one another in a solvent.
CH339624D 1956-01-28 1956-01-28 Process for the preparation of a drug compound CH339624A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH339624T 1956-01-28

Publications (1)

Publication Number Publication Date
CH339624A true CH339624A (en) 1959-07-15

Family

ID=4505075

Family Applications (1)

Application Number Title Priority Date Filing Date
CH339624D CH339624A (en) 1956-01-28 1956-01-28 Process for the preparation of a drug compound

Country Status (1)

Country Link
CH (1) CH339624A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007131813A1 (en) * 2006-05-17 2007-11-22 Basf Se Condensation products, method for their production and use thereof in medicaments, as disinfectants or as a tannin

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007131813A1 (en) * 2006-05-17 2007-11-22 Basf Se Condensation products, method for their production and use thereof in medicaments, as disinfectants or as a tannin

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