CH228854A - Process for the preparation of a basic amide. - Google Patents
Process for the preparation of a basic amide.Info
- Publication number
- CH228854A CH228854A CH228854DA CH228854A CH 228854 A CH228854 A CH 228854A CH 228854D A CH228854D A CH 228854DA CH 228854 A CH228854 A CH 228854A
- Authority
- CH
- Switzerland
- Prior art keywords
- sep
- preparation
- basic amide
- phenyl
- amide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Darstellung eines basisehen Amides. Es wurde gefunden, dass man zu einem basischen Amid gelangen kann, wenn man eine Verbindung der Formel
EMI0001.0010
worin R einen sich bei der Reaktion abspaltenden Rest bedeutet, z. B.
Phenyl - cycl,ohexyl - eseigsäure, ihre Ester, Halogenide oder ihr Anhydrid, mit Diäthyl- amino,äthyl,a-min umsetzt.
Die verfahrensgemässe Umsetzung wird zweckmässig in Gegenwart von Lösungsmit- teln vorgenommen, gegebenenfalls arbeitet man in Cregenwart von Kondensationsmitteln.
EMI0001.0036
Das <SEP> so <SEP> gewonnene <SEP> Phenyl-cyc1.ahexyl essigs#äura,diäthylaminoäthyba#md <SEP> zeigt <SEP> den
<tb> F.84-86 . <SEP> Es <SEP> soll <SEP> therapeutische <SEP> Verwen dung <SEP> finden.
<tb>
<I>Beispiel:</I>
<tb> 22 <SEP> Teile <SEP> Phienyl <SEP> - <SEP> @cyclohexyl <SEP> - <SEP> es,sigsäume
<tb> werden <SEP> in <SEP> bekannter <SEP> Weise <SEP> in <SEP> das <SEP> Säure chlorid <SEP> verwandelt. <SEP> Dieses <SEP> lässt <SEP> man <SEP> mit <SEP> des
<tb> berechneten <SEP> 1VIenge <SEP> Diäthylaminoäthylamin
<tb> reagieren. <SEP> Nach <SEP> beendigter <SEP> Umsetzung <SEP> .gibt
<tb> manWasser <SEP> und <SEP> Kaliumcarbonatlösung <SEP> hinzu
<tb> und, <SEP> .schüttelt <SEP> mit <SEP> Äther <SEP> aus. <SEP> Die <SEP> ätherische
<tb> Lösung <SEP> wird <SEP> über <SEP> Kaliumearbonatlösung <SEP> ge trocknet <SEP> und <SEP> eingedampft. <SEP> Man <SEP> erhält <SEP> so
<tb> Phenyl <SEP> - <SEP> cycl@ohexyl <SEP> - <SEP> essigs,äure-@diäthylaminoa äthylamid <SEP> vom <SEP> F. <SEP> 84-86 .
<SEP> Es <SEP> bildet <SEP> sein
<tb> Hydrochlorid <SEP> vom <SEP> F'.169-171 .
Process for the preparation of a basic amide. It has been found that a basic amide can be obtained by using a compound of the formula
EMI0001.0010
wherein R denotes a radical which is split off during the reaction, e.g. B.
Phenyl - cycl, ohexyl - acetic acid, its esters, halides or its anhydride, with diethylamino, ethyl, a-min.
The implementation according to the process is expediently carried out in the presence of solvents; if necessary, one works in the presence of condensation agents.
EMI0001.0036
The <SEP> so <SEP> obtained <SEP> Phenyl-cyc1.ahexyl acetic # aura, diethylaminoäthyba # md <SEP> shows <SEP> the
<tb> F.84-86. <SEP> <SEP> should be <SEP> therapeutic <SEP> use <SEP>.
<tb>
<I> Example: </I>
<tb> 22 <SEP> parts <SEP> Phienyl <SEP> - <SEP> @cyclohexyl <SEP> - <SEP> es, sigsäum
<tb> <SEP> are converted into <SEP> in the known <SEP> way <SEP> in <SEP> the <SEP> acid chloride <SEP>. <SEP> This <SEP> leaves <SEP> one <SEP> with <SEP> des
<tb> calculated <SEP> 1VIenge <SEP> diethylaminoethylamine
<tb> react. <SEP> After <SEP> completed <SEP> implementation <SEP>. Gives
<tb> manWater <SEP> and <SEP> potassium carbonate solution <SEP>
<tb> and, <SEP>. shakes <SEP> with <SEP> ether <SEP>. <SEP> The <SEP> essential
<tb> Solution <SEP> is <SEP> dried over <SEP> potassium carbonate solution <SEP> <SEP> and <SEP> evaporated. <SEP> You <SEP> get <SEP> like this
<tb> Phenyl <SEP> - <SEP> cycl @ ohexyl <SEP> - <SEP> acetic, acid- @ diethylaminoa äthylamid <SEP> from <SEP> F. <SEP> 84-86.
<SEP> It forms <SEP> to be <SEP>
<tb> Hydrochloride <SEP> from <SEP> F'.169-171.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH215776T | 1938-08-05 | ||
CH228854T | 1938-08-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH228854A true CH228854A (en) | 1943-09-15 |
Family
ID=25725762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH228854D CH228854A (en) | 1938-08-05 | 1938-08-05 | Process for the preparation of a basic amide. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH228854A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2563354A (en) * | 1949-07-07 | 1951-08-07 | American Cyanamid Co | Acylation of amino stilbene sulfonic acids |
EP0383256A2 (en) * | 1989-02-14 | 1990-08-22 | Fujisawa Pharmaceutical Co., Ltd. | A novel substituted-acetamide compound and a process for the preparation thereof |
US5192779A (en) * | 1989-02-14 | 1993-03-09 | Fujisawa Pharmaceutical Co., Ltd. | Substituted-acetamide compound and a process for the preparation thereof |
-
1938
- 1938-08-05 CH CH228854D patent/CH228854A/en unknown
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2563354A (en) * | 1949-07-07 | 1951-08-07 | American Cyanamid Co | Acylation of amino stilbene sulfonic acids |
EP0383256A2 (en) * | 1989-02-14 | 1990-08-22 | Fujisawa Pharmaceutical Co., Ltd. | A novel substituted-acetamide compound and a process for the preparation thereof |
EP0383256A3 (en) * | 1989-02-14 | 1992-01-02 | Fujisawa Pharmaceutical Co., Ltd. | A novel substituted-acetamide compound and a process for the preparation thereof |
US5192779A (en) * | 1989-02-14 | 1993-03-09 | Fujisawa Pharmaceutical Co., Ltd. | Substituted-acetamide compound and a process for the preparation thereof |
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