CH222486A - Process for the preparation of a diphenyl sulfone derivative. - Google Patents
Process for the preparation of a diphenyl sulfone derivative.Info
- Publication number
- CH222486A CH222486A CH222486DA CH222486A CH 222486 A CH222486 A CH 222486A CH 222486D A CH222486D A CH 222486DA CH 222486 A CH222486 A CH 222486A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- diphenyl sulfone
- sulfone derivative
- naphthylamine
- acetylamino
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Verfahren zur Herstellung eines Diplienylsulfonabkömmlings. Gegenstand des vorliegenden Patentes ist ein Verfahren zur Herstellung eines Diphenyl- sulfonabkömmlings, das dadurch gekenn zeichnet ist, dass 4-Acetylamino-diphenyl- sulfon-4'-carbaminsäurephenylester mit 2 Naphthylamin-3,6-disulfosäure in schwach alkalischer, neutraler oder schwach saurer Lösung umgesetzt wird. Das so erhältliche Produkt bildet ein schwach gelbliches Pulver, das in Wasser gut löslich ist. Es soll thera peutische Anwendung finden.
<I>Beispiel:</I> 41 g 4-Acetylamino-,diphenylsulfon-4'- carbaminsäurephenylester vom Schmelzpunkt <B>208',</B> 37,8 g 2-Naphthylamin-3,6-disulfo- säure (Mononatriumsalz) werden in 250 cm' Wasser, 2,00 cm' Diogan und 4 g Atznatron bei einem Anfangs-pH - 7,5 15 Stunden unter Rühren und Rückflusst gekocht. Danach ist der Carbaminsäurephenylester in Lösung gegangen. Die Lösung wird mit Tierkohle heiss filtriert und das Filtrat im Vakuum eingeengt.
Die eingeengte Lösung wird mit Natriumchlorid gesättigt und durch Zusatz von Salzsäure schwach kongosauer gestellt. Das Kondensationsprodukt fällt aus, wird ab gesaugt und bei 45 im Vakuum getrocknet.
Process for the preparation of a diplienyl sulfone derivative. The subject of the present patent is a process for the production of a diphenyl sulfone derivative, which is characterized in that 4-acetylamino-diphenyl sulfone-4'-carbamic acid phenyl ester with 2 naphthylamine-3,6-disulfonic acid in weakly alkaline, neutral or weakly acidic Solution is implemented. The product obtainable in this way forms a pale yellowish powder that is readily soluble in water. It should be used therapeutically.
<I> Example: </I> 41 g of 4-acetylamino-, diphenylsulphone-4'-carbamic acid phenyl ester with a melting point of <B> 208 ', </B> 37.8 g of 2-naphthylamine-3,6-disulphonic acid ( Monosodium salt) are boiled in 250 cm 'water, 2.00 cm' Diogan and 4 g caustic soda at an initial pH of 7.5 for 15 hours with stirring and reflux. The phenyl carbamate then went into solution. The solution is filtered hot with animal charcoal and the filtrate is concentrated in vacuo.
The concentrated solution is saturated with sodium chloride and made weakly Congo acidic by adding hydrochloric acid. The condensation product precipitates, is sucked off and dried at 45 in a vacuum.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE222486X | 1939-09-04 | ||
| CH218521T | 1940-08-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH222486A true CH222486A (en) | 1942-07-15 |
Family
ID=25726174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH222486D CH222486A (en) | 1939-09-04 | 1940-08-05 | Process for the preparation of a diphenyl sulfone derivative. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH222486A (en) |
-
1940
- 1940-08-05 CH CH222486D patent/CH222486A/en unknown
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