CH207654A - Process for producing a pyrimidine compound. - Google Patents

Process for producing a pyrimidine compound.

Info

Publication number
CH207654A
CH207654A CH207654DA CH207654A CH 207654 A CH207654 A CH 207654A CH 207654D A CH207654D A CH 207654DA CH 207654 A CH207654 A CH 207654A
Authority
CH
Switzerland
Prior art keywords
ethyl
pyrimidine compound
producing
amino
brominating agent
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH207654A publication Critical patent/CH207654A/en

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung einer     Pyrimidinverbindung.       Gegenstand des vorliegenden     Patentes    ist  ein Verfahren zur     Herstellung    einer     Pyri-          midinverbindung,    welches dadurch gekenn  zeichnet ist,     dass    man     2-Äthyl-4-amino-5-oxy-          methylpyrimidindurch    Einwirken eines       Bromierungsmitteells    in das     2-Äthyl-4-amino-          5-bro:

  mmethyl-pyrimidin-hydrobromid    um  wandelt.     Als        Bromierungsmittel        wird    vor  zugsweise     Bromwasserstoffs!ure        verwendet.     Die so erhältliche Verbindung bildet Kri  stalle vom     8ehmelzpunkt   <B>197'.</B> Sie soll als       Ausgangsstoff    für     chemische    Synthesen     ver-          wendet    werden.

      <I>Beispiel:</I>  20 g     2-Äthyl-4-amino-5-oxymethyIpyri-          midin    werden in     3-00    cm'     Eisessig    gelöst,     in     die Lösung wird Bromwasserstoff eingeleitet.  Dabei     steigt    die Temperatur bis gegen<B>60'.</B>  Das erst ausgeschiedene     Hydrobromid.    des  Alkohols     .geht    in Lösung,     und    nach und nach  scheidet sich .das     Hydrobromid,des        2-Äthyl-          4-a:mino-5-brommethyl-pyrimidins    in feinen       Kristallen    ab.

   Diese     werden        abgesaugt    und    mit Eisessig     und    mit Äther     :gewaschen.     F.<B>197'</B> unter     Zersetzung.     



       Da--selbe    Produkt erhält man beim Er  wärmen von     2-Äthyl-4-amino-5-oxymethyl-          pyrimidin    mit wässriger     Bromwasserstoff-          säure        (d    1,7) auf dem Wasserbad.



  Process for producing a pyrimidine compound. The subject of the present patent is a process for the preparation of a pyrimidine compound, which is characterized in that 2-ethyl-4-amino-5-oxymethylpyrimidine is added to the 2-ethyl-4-amino-5- by the action of a brominating agent. bro:

  converts mmethyl-pyrimidine-hydrobromide. Hydrogen bromic acid is preferably used as the brominating agent. The compound obtainable in this way forms crystals with a melting point <B> 197 '. </B> It is intended to be used as a starting material for chemical syntheses.

      <I> Example: </I> 20 g of 2-ethyl-4-amino-5-oxymethyIpyrimidine are dissolved in 3-00 cm 'glacial acetic acid, and hydrogen bromide is passed into the solution. The temperature rises to about <B> 60 '. </B> The hydrobromide that is first separated out. of the alcohol. goes into solution, and gradually. The hydrobromide, the 2-ethyl-4-a: mino-5-bromomethyl-pyrimidine separates in fine crystals.

   These are sucked off and washed with glacial acetic acid and with ether. F. <B> 197 '</B> with decomposition.



       The same product is obtained when 2-ethyl-4-amino-5-oxymethylpyrimidine is heated with aqueous hydrobromic acid (d 1.7) on a water bath.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer Pyrimi- dinverbindung, dadurch .gekennzeichnet, dass man 2-Äthyl-4-amin.o-5-oxymethylpyrimidin durch Einwirken eines Bromierungsmittels in das 2-Äthyl-4-amino-5-brommethylpyrimidin- hydrobromid umwandelt. Die so erhältliche Verbindung bildet Kri- stalle, die bei<B>197'</B> unter Zersetzung schmel zen. Claim: Process for the preparation of a pyrimidine compound, characterized in that 2-ethyl-4-amin.o-5-oxymethylpyrimidine is converted into 2-ethyl-4-amino-5-bromomethylpyrimidine hydrobromide by the action of a brominating agent. The compound obtainable in this way forms crystals which melt at <B> 197 '</B> with decomposition. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man als Bromierungs- mittel Bromwasserstoffsäure verwendet. SUBCLAIM: Process according to claim, characterized in that hydrobromic acid is used as the brominating agent.
CH207654D 1936-05-15 1937-04-27 Process for producing a pyrimidine compound. CH207654A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE207654X 1936-05-15
CH205894T 1937-04-27

Publications (1)

Publication Number Publication Date
CH207654A true CH207654A (en) 1939-11-15

Family

ID=25724227

Family Applications (1)

Application Number Title Priority Date Filing Date
CH207654D CH207654A (en) 1936-05-15 1937-04-27 Process for producing a pyrimidine compound.

Country Status (1)

Country Link
CH (1) CH207654A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5136896A (en) * 1990-11-26 1992-08-11 Versa Tech Engineering Rotary indexing apparatus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5136896A (en) * 1990-11-26 1992-08-11 Versa Tech Engineering Rotary indexing apparatus

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