CH206622A - Method of making a therapeutically useful compound. - Google Patents

Method of making a therapeutically useful compound.

Info

Publication number
CH206622A
CH206622A CH206622DA CH206622A CH 206622 A CH206622 A CH 206622A CH 206622D A CH206622D A CH 206622DA CH 206622 A CH206622 A CH 206622A
Authority
CH
Switzerland
Prior art keywords
making
therapeutically useful
useful compound
compound
aminobenzenesulfonamide
Prior art date
Application number
Other languages
German (de)
Inventor
Schering-Kahlbaum A G
Original Assignee
Schering Kahlbaum Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Kahlbaum Ag filed Critical Schering Kahlbaum Ag
Publication of CH206622A publication Critical patent/CH206622A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Description

  

  Verfahren zur Herstellung einer therapeutisch wertvollen Verbindung.    Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung einer neuen thera  peutisch wertvollen Verbindung, dadurch ge  kennzeichnet, dass man     4-Aminobenzolsulfon-          amid    mit einer Verbindung umsetzt, die den  Rest  
EMI0001.0003     
    an den Endstoff abgibt, wie     Phthalsäure-          anhydrid    oder ein halbseitiges     Phthalsäure-          halogenid.     



  Das so erhältliche     N-(4-Sulfamidobenzol)-          phthalsäuremonoamid    bildet farblose Nadeln,  die sich bei<B>317'</B> zersetzen.  



  <I>Beispiel:</I>  Die sorgfältig pulverisierte Mischung von  17,2 g     4-Aminobenzolsulfonamid    und 14,8 g         Phthalsäureanhydrid    wird eine Stunde auf  200   erhitzt. Das in     Natriumcarbonatlösung     aufgenommene Produkt wird mit Säure wie  der gefällt und aus viel     Alkohol    umkristalli  siert. Das     N-(4-Sulfamidobenzol)-phthalsäure-          monoamid    bildet farblose Nadeln, die sich  bei     3171    zersetzen.



  Method of making a therapeutically useful compound. The subject of the present patent is a process for the preparation of a new therapeutically valuable compound, characterized in that 4-aminobenzenesulfonamide is reacted with a compound which the remainder
EMI0001.0003
    releases to the end product, such as phthalic anhydride or a half-sided phthalic halide.



  The N- (4-sulfamidobenzene) phthalic acid monoamide obtainable in this way forms colorless needles that decompose at <B> 317 '</B>.



  <I> Example: </I> The carefully pulverized mixture of 17.2 g of 4-aminobenzenesulfonamide and 14.8 g of phthalic anhydride is heated to 200 for one hour. The product taken up in sodium carbonate solution is precipitated with acid and recrystallized from a lot of alcohol. The N- (4-sulfamidobenzene) phthalic acid monoamide forms colorless needles which decompose at 3171.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer thera peutisch wertvollen Verbindung, dadurch ge kennzeichnet, dass man 4-(Aminobenzolsulfon- amid mit einer Verbindung umsetzt, die den Rest EMI0001.0020 an den Endstoff abgibt. Das Produkt bildet farblose Nadeln vom Z. P.<B>317'</B> (aus Alkohol umkristallisiert). UNTEERANSPRÜCHE: 1.. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man Phthalsäurean- hydrid verwendet. 2. PATENT CLAIM: Process for the production of a therapeutically valuable compound, characterized in that 4- (aminobenzenesulfonamide is reacted with a compound that makes the remainder EMI0001.0020 releases to the end product. The product forms colorless needles of Z. P. <B> 317 '</B> (recrystallized from alcohol). SUBSTANTIAL CLAIMS: 1 .. Method according to patent claim, characterized in that phthalic anhydride is used. 2. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man ein halbseitiges Phthalsäurehalogenid verwendet. Process according to patent claim, characterized in that a half-sided phthalic acid halide is used.
CH206622D 1936-06-15 1937-06-09 Method of making a therapeutically useful compound. CH206622A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE206622X 1936-06-15
CH201119T 1937-06-09

Publications (1)

Publication Number Publication Date
CH206622A true CH206622A (en) 1939-08-15

Family

ID=25723681

Family Applications (1)

Application Number Title Priority Date Filing Date
CH206622D CH206622A (en) 1936-06-15 1937-06-09 Method of making a therapeutically useful compound.

Country Status (1)

Country Link
CH (1) CH206622A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2422170A (en) * 1943-07-05 1947-06-10 Sharp & Dohme Inc Sulfanilylsulfanilamide

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2422170A (en) * 1943-07-05 1947-06-10 Sharp & Dohme Inc Sulfanilylsulfanilamide

Similar Documents

Publication Publication Date Title
CH206622A (en) Method of making a therapeutically useful compound.
CH299273A (en) Process for the production of a thiosemicarbazone.
CH308749A (en) Process for producing a glycol ester.
CH311586A (en) Process for making a new salt.
CH230435A (en) Process for the production of a therapeutically valuable salt.
CH190546A (en) Process for the preparation of 5-benzoylamino-m-phenanthroline.
CH179442A (en) Process for the production of a new textile auxiliary.
CH217133A (en) Process for the production of a water-soluble, higher molecular weight, α-substituted benzylamine derivative.
CH299270A (en) Process for the preparation of a quaternary ammonium compound.
CH235238A (en) Process for the preparation of 2&#39;-methyl-cyclopentane-1 &#39;, 5-spiro-1-methyl-2,4,6-triketo-hexahydropyrimidine.
CH311595A (en) Process for making a new salt.
CH194683A (en) Process for the preparation of sulfanilic acid 2-methyl-5-aminoanilide.
CH202370A (en) Process for preparing a sulfonic acid amide compound.
CH209122A (en) Process for preparing a sulfonic acid amide compound.
CH311591A (en) Process for making a new salt.
CH230437A (en) Process for producing a benzenesulfonic acid amide compound.
CH217229A (en) Process for the preparation of 2-methyl-3-carbäthoxyamino-4-phenoxymethyl-5-cyano-6-chloropyridine.
CH237513A (en) Process for the preparation of dimethylmalonic acid-bis-diethylamide.
CH125400A (en) Process for the preparation of a substituted quinoline carboxylic acid derivative.
CH240143A (en) Process for the preparation of a basic aralkyl ether.
CH125403A (en) Process for the preparation of a substituted quinoline carboxylic acid derivative.
CH150921A (en) Process for the preparation of racemic phenylpropanolphenylpropanonmethylamine.
CH181156A (en) Process for the production of a new textile auxiliary.
CH169236A (en) Process for the preparation of a condensation product from 1,1,4-trimethyl-cycloheptene- (2) -aldehyde- (3) and acetone.
CH230980A (en) Process for the preparation of B- (p-oxyphenyl) -isopropyl-ethylamine.