CH235238A - Process for the preparation of 2'-methyl-cyclopentane-1 ', 5-spiro-1-methyl-2,4,6-triketo-hexahydropyrimidine. - Google Patents

Process for the preparation of 2'-methyl-cyclopentane-1 ', 5-spiro-1-methyl-2,4,6-triketo-hexahydropyrimidine.

Info

Publication number
CH235238A
CH235238A CH235238DA CH235238A CH 235238 A CH235238 A CH 235238A CH 235238D A CH235238D A CH 235238DA CH 235238 A CH235238 A CH 235238A
Authority
CH
Switzerland
Prior art keywords
sep
methyl
cyclopentane
spiro
hexahydropyrimidine
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH235238A publication Critical patent/CH235238A/en

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Description

  

  
EMI0001.0001     
  
    Verfahren <SEP> zur <SEP> Herstellung <SEP> von <SEP> 2'-)lethyl-eyelopentan-1',5-spiro-l-methyl  2,4,6-tr <SEP> iketo-hegahydr <SEP> opyrimidin.     
EMI0001.0002     
  
    Gegenstand <SEP> vorliegenden <SEP> Zusatzpatentes
<tb>  ist <SEP> ein <SEP> Verfahren <SEP> zur <SEP> H:erstell:ung <SEP> von
<tb>  2'- <SEP> Methyl <SEP> - <SEP> cyclopen!tan-, <SEP> 1',5,-spiro <SEP> -1- <SEP> methyl <SEP>   2,4, <SEP> 6 <SEP> - <SEP> triketo <SEP> - <SEP> hexahydropyr@imidin, <SEP> welab <SEP> es
<tb>  dadürch <SEP> :gekennzeichnet <SEP> ist, <SEP> dass <SEP> man <SEP> 2-Me  thyl-cyclopentan-1,1-,dicarbonsäureester <SEP> mit
<tb>  Mothyliharn@stoff <SEP> kondensiert.
<tb>  



  Die <SEP> neue <SEP> Verbindung <SEP> bildet <SEP> farblose <SEP> Na  deln <SEP> vom <SEP> Schmelzpunkt <SEP> 132-134  <SEP> und <SEP> be  sitzt <SEP> narkotische <SEP> Wirkung.     
EMI0001.0003     
  
    <I>Beispiel:</I>       4,6     Teile    Natrium werden in 70     Teilen          Alkohol        gelöst,    zur Lösung 12     Teile        Methyl-          harnistoff    und '21 Teile     2-Methy        1-cyclopentan-          1.,

  1adiicaarbon6!äure-diäthyle6ter        zugefügt    und  die     Lösung    3     Stunden    am     Rückfluss    gekocht.  Dann destilliert man den     Alkohol    ab, löst  dien     Rückstand    in     Eiswasser    und fällt mit         Essigsäure    das     2'-Methyl-cyclopentan-1',5-          spiro    - 1 -     methyl    - 2';4;6 -     triketo    -     hexahydro-          pyriimndin    ;aus.

   Die neue Verbindung kristal  lisiert aus verdünntem     Methylalkohol    in  feinen, farblosen:, prismatischen Nadeln vom  F. 132 bis 134 . Sie ist in Wasser schwer, in  organischen     Lösungsmitteln        leichter    lös dich.



  
EMI0001.0001
  
    Process <SEP> for <SEP> production <SEP> of <SEP> 2 '-) lethyl-eyelopentan-1', 5-spiro-l-methyl 2,4,6-tr <SEP> iketo-hegahydr <SEP> opyrimidine.
EMI0001.0002
  
    Subject <SEP> of the present <SEP> additional patent
<tb> is <SEP> a <SEP> procedure <SEP> for <SEP> H: create: ung <SEP> from
<tb> 2'- <SEP> methyl <SEP> - <SEP> cyclopen! tan-, <SEP> 1 ', 5, -spiro <SEP> -1- <SEP> methyl <SEP> 2,4, < SEP> 6 <SEP> - <SEP> triketo <SEP> - <SEP> hexahydropyr @ imidin, <SEP> welab <SEP> es
<tb> with <SEP>: marked <SEP>, <SEP> that <SEP> man <SEP> 2-methyl-cyclopentane-1,1-, dicarboxylic acid ester <SEP> with
<tb> Mothyliharn @ stoff <SEP> condensed.
<tb>



  The <SEP> new <SEP> compound <SEP> forms <SEP> colorless <SEP> needles <SEP> with a <SEP> melting point <SEP> 132-134 <SEP> and <SEP> has <SEP> narcotic < SEP> effect.
EMI0001.0003
  
    <I> Example: </I> 4.6 parts of sodium are dissolved in 70 parts of alcohol, 12 parts of methyl urea and 21 parts of 2-methyl 1-cyclopentane-1 to dissolve.

  1adiicaarbon6! Äure-diethyle6ter was added and the solution refluxed for 3 hours. The alcohol is then distilled off, the residue is dissolved in ice water and 2'-methyl-cyclopentane-1 ', 5-spiro-1-methyl-2'; 4; 6-triketo-hexahydropyrimindine is precipitated with acetic acid.

   The new compound crystallizes from dilute methyl alcohol in fine, colorless :, prismatic needles with a F. 132 to 134. It is difficult in water, easier to dissolve in organic solvents.

Claims (1)

PATENTANSPRUCH: EMI0001.0031 Verfahren <SEP> zur <SEP> Herstellung <SEP> von <SEP> 2'-Methyl cyclo#pentan-,1',5=spiTo-l-merthyl-2,4,6-triketot hexahydropyrimidin, <SEP> dadurch <SEP> gekennzeich net, <SEP> @dass <SEP> man <SEP> 2-Me@thyl-cyclopentan-1,1-di carbonsäureester <SEP> mit <SEP> @ethylha;rnstoff <SEP> kon densiert. <tb> Die <SEP> neue <SEP> Verbindung <SEP> bildet <SEP> farblose <SEP> Na deln <SEP> vom <SEP> Schmelzpunkt <SEP> 132-134 <SEP> und <SEP> be sitzt <SEP> narkotische <SEP> Wirkung. PATENT CLAIM: EMI0001.0031 Process <SEP> for <SEP> production <SEP> of <SEP> 2'-methyl cyclo # pentan-, 1 ', 5 = spiTo-l-merthyl-2,4,6-triketot hexahydropyrimidine, <SEP> thereby < SEP> marked, <SEP> @that <SEP> 2-methyl-cyclopentane-1,1-di-carboxylic acid ester <SEP> is condensed with <SEP> @ethyl urea <SEP>. <tb> The <SEP> new <SEP> connection <SEP> forms <SEP> colorless <SEP> needles <SEP> with a <SEP> melting point <SEP> 132-134 <SEP> and <SEP> has <SEP > narcotic <SEP> effect.
CH235238D 1942-07-29 1942-07-29 Process for the preparation of 2'-methyl-cyclopentane-1 ', 5-spiro-1-methyl-2,4,6-triketo-hexahydropyrimidine. CH235238A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH235238T 1942-07-29
CH230367T 1942-07-29

Publications (1)

Publication Number Publication Date
CH235238A true CH235238A (en) 1944-11-15

Family

ID=25727477

Family Applications (1)

Application Number Title Priority Date Filing Date
CH235238D CH235238A (en) 1942-07-29 1942-07-29 Process for the preparation of 2'-methyl-cyclopentane-1 ', 5-spiro-1-methyl-2,4,6-triketo-hexahydropyrimidine.

Country Status (1)

Country Link
CH (1) CH235238A (en)

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