CH179320A - Process for the preparation of an indole series aldehyde. - Google Patents
Process for the preparation of an indole series aldehyde.Info
- Publication number
- CH179320A CH179320A CH179320DA CH179320A CH 179320 A CH179320 A CH 179320A CH 179320D A CH179320D A CH 179320DA CH 179320 A CH179320 A CH 179320A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- aldehyde
- indole series
- methylformylaniline
- phenyl
- Prior art date
Links
Landscapes
- Indole Compounds (AREA)
Description
Verfahren zur Darstellung eines Aldehyds der Indolreihe. Uegenständ des vorliegenden Zusatz patentes ist ein Verfahren zur Darstellung eines Aldehyds der Indolreihe, welches da durch gekennzeichnet. ist, dass man 1-Methyl- 2-phenyl-6-nitroiridol, Methylformylanilin und ein chlorhaltiges saures Kondensationsmittel aufeinander einwirken lässt.
Beispiel: Zu 10,4 Gewichtsteilen Methylformylani- lin werden 12,5 Gewichtsteile Phosphorosy- chlorid gegeben, wobei unter Erwärmung Reaktion eintritt. Nach zweistündigem Nach rühren wird mit 40 Gewichtsteilen o-Dichlor- benzol verdünnt und auf ca. 5110 abgekühlt. Hierauf werden unter Rühren portionsweise 19 Gewielitsteile 1-Methyl-2-pheriyl-6-nitro- indol in der Weise eingetragen, dass die Temperatur nicht über 10 C steigt.
Nach ca. 15stündigem Stehenlassen bei gewöhn licher Temperatur wird mit 200 Gewichts- teilen Eis, dem 100 Gewichtsteile Natron lauge 40 o B6 zugesetzt sind, gut ausgerührt, die Dichlorbenzollösung im Scheidetrichter getrennt und im Vakuum destilliert.
Nach dem zunächst das o-Dichlorbenzol und das wiedergewonnene Monomethylanilin abdestil- liert sind, erhält man 1-Methyl-2-phenyl-6- riitroindol-3-aldehyd in einer Ausbeute von 85,3 % der Theorie. Der Aldehyd schmilzt bei<B>2330</B> C. Er soll zur Darstellung von Farbstoffen Verwendung finden.
Process for the preparation of an indole series aldehyde. The subject of the present additional patent is a process for the preparation of an aldehyde of the indole series, which is characterized by. is that 1-methyl-2-phenyl-6-nitroiridol, methylformylaniline and a chlorine-containing acidic condensation agent are allowed to interact.
Example: 12.5 parts by weight of phosphorosyl chloride are added to 10.4 parts by weight of methylformylaniline, a reaction taking place when heated. After stirring for two hours, the mixture is diluted with 40 parts by weight of o-dichlorobenzene and cooled to approx. Then 19 parts by weight of 1-methyl-2-pheriyl-6-nitro-indole are added in portions with stirring in such a way that the temperature does not rise above 10.degree.
After standing for about 15 hours at the usual temperature, 200 parts by weight of ice to which 100 parts by weight of sodium hydroxide solution 40 ° B6 have been added, stirred well, the dichlorobenzene solution separated in a separating funnel and distilled in vacuo.
After the o-dichlorobenzene and the recovered monomethylaniline have first been distilled off, 1-methyl-2-phenyl-6-nitroindole-3-aldehyde is obtained in a yield of 85.3% of theory. The aldehyde melts at <B> 2330 </B> C. It is intended to be used to represent dyes.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE179320X | 1933-05-13 | ||
CH175349T | 1934-05-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH179320A true CH179320A (en) | 1935-08-31 |
Family
ID=25719655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH179320D CH179320A (en) | 1933-05-13 | 1934-05-11 | Process for the preparation of an indole series aldehyde. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH179320A (en) |
-
1934
- 1934-05-11 CH CH179320D patent/CH179320A/en unknown
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