CH151182A - Process for the preparation of a crystallized, readily soluble and stable benzylmorphine salt. - Google Patents

Process for the preparation of a crystallized, readily soluble and stable benzylmorphine salt.

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Publication number
CH151182A
CH151182A CH151182DA CH151182A CH 151182 A CH151182 A CH 151182A CH 151182D A CH151182D A CH 151182DA CH 151182 A CH151182 A CH 151182A
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CH
Switzerland
Prior art keywords
benzylmorphine
crystallized
preparation
salt
stable
Prior art date
Application number
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German (de)
Inventor
Sandoz Chemische Fabri Vormals
Original Assignee
Chem Fab Vormals Sandoz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Fab Vormals Sandoz filed Critical Chem Fab Vormals Sandoz
Publication of CH151182A publication Critical patent/CH151182A/en

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Description

  

  Verfahren     zur    Darstellung eines     kristallisierten,        leichtlöslichen    und     beständigen          Benzylmorphinsalzes.       Die vorliegende Erfindung     betrifft    ein Ver  fahren zur Darstellung eines kristallisierten,  leichtlöslichen, beständigen     Benzylinorphin-          salzes,    welches dadurch gekennzeichnet ist,  dass man     Benzylmorphinbase    und     Äthansulfon-          säure    aufeinander einwirken lässt.  



  <I>Beispiel:</I>  100     gr        Benzylmorphin    werden in 300 cm-'  absolutem Alkohol gelöst und mit     10(f        cms          einer        30        %igen        alkoholischen    Ätharisulfon-         säure    versetzt. Beim Verdünnen mit trockenem  Äther kristallisiert der grösste Teil des     äthan-          sulfonsauren        Benzylmorphins    in     Drusen    aus;  durch Einengen der     Mutterlauge    wird der       liest    des Salzes gewonnen.

    



  Ein Teil desselben löst sich in 0,7 Teilen  Wasser von 200 zu einer neutral reagieren  den Flüssigkeit. Das     ätbansulfonsaure        Benzyl-          morphin    verfärbt sich bei langsamem Erhitzen  gegen 190 0 und schmilzt unter Braunfärbung  bei 201-202 0.

      Die Analyse ergab  <B>0,2192</B>     gr    Substanz: 4,39     cm3    n/10     H2S04    nach     Kjeldahl     7,110     mgr        ,i    3,352     mgr        BaS04    mikroanalytisch       C19H18NOS.        ((:H2.        CrH6).        C2116S03H        Ber.        N        2,88%;        S        6,61%;

            Gef.        N        2,81%;        S        6,48        0%.       Das Produkt ergibt Reaktionen des     Benzyl-          morphins.  



  Process for the preparation of a crystallized, readily soluble and stable benzylmorphine salt. The present invention relates to a method for preparing a crystallized, easily soluble, stable benzylinorphine salt, which is characterized in that benzylmorphine base and ethanesulfonic acid are allowed to act on one another.



  <I> Example: </I> 100 g of benzylmorphine are dissolved in 300 cm- 'absolute alcohol and mixed with 10 (f cms of a 30% alcoholic etharisulphonic acid. When diluted with dry ether, most of the ethane sulphonic acid crystallizes Benzylmorphine in drusen; the extract of the salt is obtained by concentrating the mother liquor.

    



  A part of it dissolves in 0.7 parts of water from 200 to a neutral reacting liquid. The benzylmorphine ätbansulfonsaure discolored when slowly heated to 190 0 and melts with a brown color at 201-202 0.

      The analysis resulted in <B> 0.2192 </B> gr substance: 4.39 cm3 n / 10 H2S04 according to Kjeldahl 7.110 mgr, i 3.352 mgr BaS04 microanalytically C19H18NOS. ((: H2. CrH6). C2116S03H calc. N 2.88%; S 6.61%;

            Found N 2.81%; S 6.48 0%. The product results in reactions of benzylmorphine.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines kristalli sierten, leichtlöslichen und beständigen Benzyl- . morphinsalzes, dadurch. gekennzeichnet, dass man Benzylmorphinbase und Äthansulfon- säure aufeinander einwirken lässt. Das erhaltene äthansulfonsaure Benzyl- morphin bildet feine Kristalle, die zu Drusen vereinigt sind. PATENT CLAIM: Process for the preparation of a crystallized, easily soluble and stable benzyl. morphine salt, thereby. characterized in that benzylmorphine base and ethanesulfonic acid are allowed to interact. The ethanesulfonic acid benzylmorphine obtained forms fine crystals which are combined to form drusen. Es löst sich in 0,7 Teilen Wasser von 201 C zu einer neutral reagie renden Flüssigkeit und verfärbt sich beim langsamen Erhitzen gegen 190 C und schmilzt unter Braunfärbung bei 201-202' C. Mit Molybdänschwefelsäure ergibt die neue Verbindung eine charakteristische Violett färbung. Nach der Analyse besitzt die neue Ver bindung folgende Konstitution C1zH1aN0s(CH2-CcH5) . C2H5-S08H. It dissolves in 0.7 parts of water at 201 ° C. to form a neutral reacting liquid and changes color when heated slowly to 190 ° C. and melts with a brown color at 201-202 ° C. With molybdenum sulfuric acid, the new compound gives a characteristic purple color. According to the analysis, the new compound has the following constitution C1zH1aN0s (CH2-CcH5). C2H5-S08H.
CH151182D 1929-05-24 1930-05-23 Process for the preparation of a crystallized, readily soluble and stable benzylmorphine salt. CH151182A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE151182X 1929-05-24
CH148913T 1930-05-23

Publications (1)

Publication Number Publication Date
CH151182A true CH151182A (en) 1931-11-30

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CH151182D CH151182A (en) 1929-05-24 1930-05-23 Process for the preparation of a crystallized, readily soluble and stable benzylmorphine salt.

Country Status (1)

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CH (1) CH151182A (en)

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