CH134276A - Process for the preparation of a condensation product of the benzodiazine series. - Google Patents

Process for the preparation of a condensation product of the benzodiazine series.

Info

Publication number
CH134276A
CH134276A CH134276DA CH134276A CH 134276 A CH134276 A CH 134276A CH 134276D A CH134276D A CH 134276DA CH 134276 A CH134276 A CH 134276A
Authority
CH
Switzerland
Prior art keywords
condensation product
benzodiazine
series
preparation
aminobenzene
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH134276A publication Critical patent/CH134276A/en

Links

Description

  

      Verfahren    zur Darstellung eines Kondensationsproduktes der     Benzodiazinreihe.       Gegenstand dieses Patentes ist ein Ver  fahren zur Darstellung eines Kondensations  produktes der     Benzodiazinreihe    von der  Formel  
EMI0001.0004     
    welches dadurch gekennzeichnet ist, dass man  1     Mol.        2.4-Dihalogenchinazolin    mit 2     Mol.        4-          Nitro-l-aminobenzol-3-sulfosäure    kondensiert.  



  Das Kondensationsprodukt soll als Zwi  schenprodukt für Farbstoffe oder auch für  pharmazeutische Produkte gebraucht werden.  <I>Beispiel:</I>  19,9 Gewichtsteile leinst gepulvertes     2.4-          Dichlorchinazolin    werden in 100 Gewichts  teilen Wasser suspendiert. Man gibt dazu  eine Lösung von 24,0 Gewichtsteilen des         Natriumsalzes    der     4-Nitro-l-aminobenzol-3-          sulfosäure    und erhitzt unter gutem Rühren  auf 45  bis die     4-Nitro-l-aminobenzol-3-sulfo-          säure    nicht mehr nachweisbar ist.

   Die lack  mussaure Lösung enthält jetzt das noch  chlorhaltige Kondensationsprodukt aus einem  Molekül     2.4-Dichlorchinazolin    und einem  Molekül     4-Nitro        -1-aminobenzol-3-sulfosäure,     das man zum Beispiel durch     .Gussalzen    als  gelbliches Pulver isolieren kann. Inzwischen  hat man eine neutrale wässerige, auf 70-85   erhitzte Lösung von weiteren 24 Gewichts  teilen des     Natriumsalzes    der     4-Nitro-l-amino-          benzol-3-sulfosäure    bereitet. Zu dieser Lösung  tropft man unter sehr gutem Rühren langsam  die auf schwach     lackmussauer    gestellte obige  Lösung des chlorhaltigen Zwischenkörpers.

    Nach beendigtem     Zutropfen    hält man noch  einige Zeit auf 85 , lässt abkühlen, macht  schwach kongosauer und salzt aus. Das  Kondensationsprodukt aus 1     Mol.        2.4-Dichlor-          chinazolin    und 2     Mol.    4-Nitro-l-aminobenzol-           3-sulfosäure    bildet ein schwach rötliches  Pulver, das in Wasser mit gelber Farbe  löslich ist.  



  Die neue Verbindung reagiert nicht mehr  mit salpetriger Säure; sie lässt sich zum  Beispiel durch Eisen und Essigsäure leicht  zur entsprechenden     Diaminoverbindung    redu  zieren.



      Process for the preparation of a condensation product of the benzodiazine series. The subject of this patent is a process for the representation of a condensation product of the benzodiazine series of the formula
EMI0001.0004
    which is characterized in that 1 mole of 2,4-dihaloquinazoline is condensed with 2 moles of 4-nitro-1-aminobenzene-3-sulfonic acid.



  The condensation product should be used as an inter mediate product for dyes or for pharmaceutical products. <I> Example: </I> 19.9 parts by weight of powdered 2.4-dichloroquinazoline are suspended in 100 parts by weight of water. A solution of 24.0 parts by weight of the sodium salt of 4-nitro-1-aminobenzene-3-sulfonic acid is added and heated to 45 with thorough stirring until the 4-nitro-1-aminobenzene-3-sulfonic acid can no longer be detected .

   The lacquer acidic solution now contains the condensation product still containing chlorine from a molecule of 2,4-dichloroquinazoline and a molecule of 4-nitro-1-aminobenzene-3-sulphonic acid, which can be isolated as a yellowish powder using cast salts, for example. In the meantime, a neutral aqueous solution, heated to 70-85, of a further 24 parts by weight of the sodium salt of 4-nitro-1-aminobenzene-3-sulfonic acid has been prepared. The above solution of the intermediate body containing chlorine is slowly added dropwise to this solution while stirring very well.

    After the dropping is complete, hold at 85 for a while, let it cool down, make weak Congo acidic and salt out. The condensation product of 1 mole of 2,4-dichloroquinazoline and 2 moles of 4-nitro-1-aminobenzene-3-sulfonic acid forms a pale reddish powder which is soluble in water with a yellow color.



  The new compound no longer reacts with nitrous acid; it can be easily reduced to the corresponding diamino compound, for example with iron and acetic acid.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung. eines Konden sationsproduktes der Benzodiazinreihe von der Formel: EMI0002.0005 dadurch gekennzeichnet, dass man 1 Mol. 2.4-Dihalogenchinazolin mit 2 Mol. 4-Nitro- 1-aminobenzol-3-sulfosäure kondensiert. Das Kondensationsprodukt soll als Zwi schenprodukt für Farbstoffe oder auch für pharmazeutische Produkte gebraucht werden. Das Kondensationsprodukt bildet ein schwach rötliches Pulver, das in Wasser mit gelber Farbe löslich ist. Es reagiert nicht mehr mit salpetriger Säure. PATENT CLAIM: Method of representation. of a condensation product of the benzodiazine series of the formula: EMI0002.0005 characterized in that 1 mole of 2,4-dihaloquinazoline is condensed with 2 moles of 4-nitro-1-aminobenzene-3-sulfonic acid. The condensation product should be used as an inter mediate product for dyes or for pharmaceutical products. The condensation product forms a pale reddish powder that is soluble in water with a yellow color. It no longer reacts with nitrous acid.
CH134276D 1926-12-13 1927-12-12 Process for the preparation of a condensation product of the benzodiazine series. CH134276A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE134276X 1926-12-13
CH133192T 1927-12-12

Publications (1)

Publication Number Publication Date
CH134276A true CH134276A (en) 1929-07-15

Family

ID=25711987

Family Applications (1)

Application Number Title Priority Date Filing Date
CH134276D CH134276A (en) 1926-12-13 1927-12-12 Process for the preparation of a condensation product of the benzodiazine series.

Country Status (1)

Country Link
CH (1) CH134276A (en)

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