CA3234178A1 - Improved tnf binders - Google Patents

Improved tnf binders Download PDF

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Publication number
CA3234178A1
CA3234178A1 CA3234178A CA3234178A CA3234178A1 CA 3234178 A1 CA3234178 A1 CA 3234178A1 CA 3234178 A CA3234178 A CA 3234178A CA 3234178 A CA3234178 A CA 3234178A CA 3234178 A1 CA3234178 A1 CA 3234178A1
Authority
CA
Canada
Prior art keywords
amino acid
seq
tnf
isvd
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3234178A
Other languages
English (en)
French (fr)
Inventor
Marie-Ange Buyse
Joachim Boucneau
Peter Casteels
Gino Van Heeke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ablynx NV
Original Assignee
Ablynx NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx NV filed Critical Ablynx NV
Publication of CA3234178A1 publication Critical patent/CA3234178A1/en
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Organic Insulating Materials (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CA3234178A 2015-11-12 2016-11-14 Improved tnf binders Pending CA3234178A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562254375P 2015-11-12 2015-11-12
US62/254,375 2015-11-12
CA3005085A CA3005085C (en) 2015-11-12 2016-11-14 IMPROVED TNF BINDERS

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3005085A Division CA3005085C (en) 2015-11-12 2016-11-14 IMPROVED TNF BINDERS

Publications (1)

Publication Number Publication Date
CA3234178A1 true CA3234178A1 (en) 2017-05-18

Family

ID=57348648

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3234178A Pending CA3234178A1 (en) 2015-11-12 2016-11-14 Improved tnf binders
CA3005085A Active CA3005085C (en) 2015-11-12 2016-11-14 IMPROVED TNF BINDERS

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3005085A Active CA3005085C (en) 2015-11-12 2016-11-14 IMPROVED TNF BINDERS

Country Status (37)

Country Link
US (2) US10544211B2 (OSRAM)
EP (2) EP3191511B1 (OSRAM)
JP (2) JP6962915B2 (OSRAM)
KR (2) KR20240029115A (OSRAM)
CN (1) CN108473563B (OSRAM)
AU (2) AU2016352943B2 (OSRAM)
BR (1) BR112018009714A8 (OSRAM)
CA (2) CA3234178A1 (OSRAM)
CL (1) CL2018001291A1 (OSRAM)
CO (1) CO2018005915A2 (OSRAM)
CR (1) CR20180311A (OSRAM)
CY (1) CY1120303T1 (OSRAM)
DK (1) DK3191511T3 (OSRAM)
DO (1) DOP2018000122A (OSRAM)
EC (1) ECSP18042569A (OSRAM)
ES (1) ES2662418T3 (OSRAM)
GT (1) GT201800095A (OSRAM)
HK (1) HK1248716A1 (OSRAM)
HR (1) HRP20171949T1 (OSRAM)
HU (1) HUE035805T2 (OSRAM)
IL (2) IL310373A (OSRAM)
LT (1) LT3191511T (OSRAM)
MA (1) MA41653A (OSRAM)
MD (1) MD3191511T2 (OSRAM)
ME (1) ME02954B (OSRAM)
MX (1) MX385207B (OSRAM)
NO (1) NO2768984T3 (OSRAM)
PE (1) PE20181317A1 (OSRAM)
PH (1) PH12018501025A1 (OSRAM)
PL (1) PL3191511T3 (OSRAM)
PT (1) PT3191511T (OSRAM)
RS (1) RS56676B1 (OSRAM)
SG (1) SG11201803975SA (OSRAM)
SI (1) SI3191511T1 (OSRAM)
SM (1) SMT201700590T1 (OSRAM)
TN (1) TN2018000159A1 (OSRAM)
WO (1) WO2017081320A1 (OSRAM)

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DK2723769T4 (da) 2011-06-23 2022-09-05 Ablynx Nv Teknikker til at forudsige, påvise og reducere uspecifik proteininterferens i assays, som involverer variable immunglobulin-enkeltdomæner
IL295534B2 (en) 2014-05-16 2025-03-01 Ablynx Nv Improved immunoglobulin variable sites
IL318433A (en) 2014-05-16 2025-03-01 Ablynx Nv Improved immunoglobulin variable complexes
NO2768984T3 (OSRAM) * 2015-11-12 2018-06-09
GB201522394D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
IL293554A (en) * 2019-12-06 2022-08-01 Ablynx Nv Polypeptides comprising an immunoglobulin with one variable domain that target tnfa and ox40l
IL293561A (en) * 2019-12-06 2022-08-01 Ablynx Nv Polypeptides comprising immunoglobulin with one variable domain targeting TNFa and IL-23
CN112300289B (zh) * 2019-12-30 2022-06-10 中国药科大学 RGD4C融合抗TNFα纳米抗体蛋白、制备方法及其应用
KR20230123497A (ko) * 2020-12-18 2023-08-23 아블린쓰 엔.브이. IL-6 및 TNF-α를 표적화하는 면역글로불린 단일 가변도메인을 포함하는 폴리펩티드
WO2023093899A1 (zh) * 2021-11-29 2023-06-01 江苏恒瑞医药股份有限公司 经修饰的蛋白或多肽
EP4611728A1 (en) * 2022-11-04 2025-09-10 St. Jude Children's Research Hospital, Inc. Nlrp12 and nlrc5 modulators and methods for using the same to modulate diseases
US20240415974A1 (en) 2022-12-23 2024-12-19 Ablynx N.V. Protein-based conjugation carriers
AR131869A1 (es) 2023-02-17 2025-05-07 Ablynx Nv POLIPÉPTIDOS QUE SE UNEN AL RECEPTOR DE Fc NEONATAL

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DK2723769T4 (da) * 2011-06-23 2022-09-05 Ablynx Nv Teknikker til at forudsige, påvise og reducere uspecifik proteininterferens i assays, som involverer variable immunglobulin-enkeltdomæner
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Also Published As

Publication number Publication date
ES2662418T3 (es) 2018-04-06
IL259269A (en) 2018-07-31
AU2023200113A1 (en) 2023-02-16
EP3266798A3 (en) 2018-03-28
CN108473563A (zh) 2018-08-31
HRP20171949T1 (hr) 2018-01-26
SMT201700590T1 (it) 2018-01-11
RU2018120524A (ru) 2019-12-13
MA41653A (fr) 2018-01-09
RU2018120524A3 (OSRAM) 2020-09-24
SI3191511T1 (en) 2018-01-31
US20170267752A1 (en) 2017-09-21
CR20180311A (es) 2018-10-18
JP2019506839A (ja) 2019-03-14
PE20181317A1 (es) 2018-08-14
RS56676B1 (sr) 2018-03-30
BR112018009714A8 (pt) 2019-02-26
HK1248716A1 (en) 2018-10-19
WO2017081320A1 (en) 2017-05-18
JP2022020666A (ja) 2022-02-01
DOP2018000122A (es) 2018-09-30
AU2016352943B2 (en) 2022-10-20
GT201800095A (es) 2019-08-15
IL310373A (en) 2024-03-01
IL259269B2 (en) 2024-07-01
KR102641194B1 (ko) 2024-02-26
MD3191511T2 (ro) 2018-03-31
SG11201803975SA (en) 2018-06-28
IL259269B1 (en) 2024-03-01
ME02954B (me) 2018-07-20
PL3191511T3 (pl) 2018-03-30
ECSP18042569A (es) 2018-07-31
JP6962915B2 (ja) 2021-11-10
MX385207B (es) 2025-03-04
KR20180083382A (ko) 2018-07-20
EP3191511A1 (en) 2017-07-19
US10544211B2 (en) 2020-01-28
AU2016352943A1 (en) 2018-06-07
CA3005085C (en) 2024-09-10
JP7357038B2 (ja) 2023-10-05
US9745372B2 (en) 2017-08-29
KR20240029115A (ko) 2024-03-05
DK3191511T3 (en) 2018-01-08
LT3191511T (lt) 2018-01-10
NO2768984T3 (OSRAM) 2018-06-09
CA3005085A1 (en) 2017-05-18
CO2018005915A2 (es) 2018-06-20
TN2018000159A1 (en) 2019-10-04
PT3191511T (pt) 2017-11-30
CY1120303T1 (el) 2019-07-10
HUE035805T2 (en) 2018-05-28
PH12018501025A1 (en) 2019-01-28
BR112018009714A2 (en) 2018-11-21
CL2018001291A1 (es) 2018-09-14
US20170190769A1 (en) 2017-07-06
EP3266798A2 (en) 2018-01-10
EP3191511B1 (en) 2017-09-20
MX2018005992A (es) 2019-01-31
CN108473563B (zh) 2022-06-14

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