CA3232833A1 - Chimeric receptor polypeptides in combination with trans metabolism molecules that re-direct glucose metabolites out of the glycolysis pathway and therapeutic uses thereof - Google Patents

Chimeric receptor polypeptides in combination with trans metabolism molecules that re-direct glucose metabolites out of the glycolysis pathway and therapeutic uses thereof Download PDF

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Publication number
CA3232833A1
CA3232833A1 CA3232833A CA3232833A CA3232833A1 CA 3232833 A1 CA3232833 A1 CA 3232833A1 CA 3232833 A CA3232833 A CA 3232833A CA 3232833 A CA3232833 A CA 3232833A CA 3232833 A1 CA3232833 A1 CA 3232833A1
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cd8a
domain
scfv
cells
cd3c
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CA3232833A
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English (en)
French (fr)
Inventor
Kathleen Mcginness
Seth Ettenberg
Luke BARRON
Michael Fray
Charles Wilson
Gregory MOTZ
Samyabrata BHADURI
Amy JENSEN
Emily KUIPER
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Sotio Biotech Inc
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Sotio Biotech Inc
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N5/0602—Vertebrate cells
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    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01016—Glutamine-fructose-6-phosphate transaminase (isomerizing) (2.6.1.16), i.e. glucosamine-6-phosphate-synthase
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    • C12Y207/11032—[Pyruvate, phosphate dikinase] kinase (2.7.11.32)
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03046—Fructose-2,6-bisphosphate 2-phosphatase (3.1.3.46)
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2319/00—Fusion polypeptide
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    • C12N2840/00—Vectors comprising a special translation-regulating system
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CA3232833A 2021-09-27 2022-09-27 Chimeric receptor polypeptides in combination with trans metabolism molecules that re-direct glucose metabolites out of the glycolysis pathway and therapeutic uses thereof Pending CA3232833A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163248629P 2021-09-27 2021-09-27
US63/248,629 2021-09-27
US202263399324P 2022-08-19 2022-08-19
US63/399,324 2022-08-19
PCT/US2022/077103 WO2023049933A1 (en) 2021-09-27 2022-09-27 Chimeric receptor polypeptides in combination with trans metabolism molecules that re-direct glucose metabolites out of the glycolysis pathway and therapeutic uses thereof

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CA3232833A1 true CA3232833A1 (en) 2023-03-30

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CA3232833A Pending CA3232833A1 (en) 2021-09-27 2022-09-27 Chimeric receptor polypeptides in combination with trans metabolism molecules that re-direct glucose metabolites out of the glycolysis pathway and therapeutic uses thereof

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US (1) US20240390495A1 (enExample)
EP (1) EP4408982A1 (enExample)
JP (1) JP2024536859A (enExample)
KR (1) KR20240069799A (enExample)
AU (1) AU2022349103A1 (enExample)
CA (1) CA3232833A1 (enExample)
IL (1) IL311712A (enExample)
MX (1) MX2024004009A (enExample)
WO (1) WO2023049933A1 (enExample)

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JP7456638B2 (ja) * 2018-08-14 2024-03-27 ソティオ，リミティド ライアビリティ カンパニー クレブス回路を調節するトランス代謝分子と組み合わせたキメラ抗原受容体ポリペプチド、及び、それらの治療的使用
WO2024040207A1 (en) 2022-08-19 2024-02-22 Sotio Biotech Inc. Genetically engineered natural killer (nk) cells with chimeric receptor polypeptides in combination with trans metabolism molecules and therapeutic uses thereof
WO2024040208A1 (en) 2022-08-19 2024-02-22 Sotio Biotech Inc. Genetically engineered immune cells with chimeric receptor polypeptides in combination with multiple trans metabolism molecules and therapeutic uses thereof
WO2024215987A1 (en) 2023-04-14 2024-10-17 Sotio Biotech Inc. IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES
EP4694916A1 (en) 2023-04-14 2026-02-18 SOTIO Biotech Inc. Engineered immune cells for treating cancer in combination with il-2/il-15 receptor ?? agonists
WO2025038646A1 (en) * 2023-08-14 2025-02-20 Intellia Therapeutics, Inc. Cd70 car-t compositions and methods for cell-based therapy

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