CA3229559A1 - Novel crystalline polymorph of lurbinectedin and improved process for the preparation of lurbinectedin - Google Patents

Novel crystalline polymorph of lurbinectedin and improved process for the preparation of lurbinectedin Download PDF

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Publication number
CA3229559A1
CA3229559A1 CA3229559A CA3229559A CA3229559A1 CA 3229559 A1 CA3229559 A1 CA 3229559A1 CA 3229559 A CA3229559 A CA 3229559A CA 3229559 A CA3229559 A CA 3229559A CA 3229559 A1 CA3229559 A1 CA 3229559A1
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CA
Canada
Prior art keywords
lurbinectedin
crystalline polymorph
preparation
compound
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3229559A
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English (en)
French (fr)
Inventor
Srinivasa Chary CHINTALAPATI
Thirupathi Kotte
Srinivasan ABAYEE KALIYAPERUMAL
Shankar Reddy BUDIDETI
Pulla Reddy Muddasani
Venkaiah Chowdary Nannapaneni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Natco Pharma Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA3229559A1 publication Critical patent/CA3229559A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CA3229559A 2021-08-31 2022-08-30 Novel crystalline polymorph of lurbinectedin and improved process for the preparation of lurbinectedin Pending CA3229559A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN202141039393 2021-08-31
IN202141039393A IN202141039393A (https=) 2021-08-31 2021-08-31
PCT/IN2022/050772 WO2023031960A1 (en) 2021-08-31 2022-08-30 Novel crystalline polymorph of lurbinectedin and improved process for the preparation of lurbinectedin

Publications (1)

Publication Number Publication Date
CA3229559A1 true CA3229559A1 (en) 2023-03-09

Family

ID=85412216

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3229559A Pending CA3229559A1 (en) 2021-08-31 2022-08-30 Novel crystalline polymorph of lurbinectedin and improved process for the preparation of lurbinectedin

Country Status (4)

Country Link
US (1) US20240352039A1 (https=)
CA (1) CA3229559A1 (https=)
IN (1) IN202141039393A (https=)
WO (1) WO2023031960A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025059336A1 (en) * 2023-09-13 2025-03-20 Navinta, Llc An improved process for preparation of lurbinectedin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
MA56827B2 (fr) * 2019-11-21 2023-09-27 Pharma Mar Sa Procédés de traitement du cancer du poumon à petites cellules avec des formulations de lurbinectédine

Also Published As

Publication number Publication date
US20240352039A1 (en) 2024-10-24
WO2023031960A1 (en) 2023-03-09
IN202141039393A (https=) 2023-03-03

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