CA3228678A1 - Methods of reducing production of iga, igm and/or igg using sbcma variants and fc fusion proteins thereof - Google Patents
Methods of reducing production of iga, igm and/or igg using sbcma variants and fc fusion proteins thereof Download PDFInfo
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- CA3228678A1 CA3228678A1 CA3228678A CA3228678A CA3228678A1 CA 3228678 A1 CA3228678 A1 CA 3228678A1 CA 3228678 A CA3228678 A CA 3228678A CA 3228678 A CA3228678 A CA 3228678A CA 3228678 A1 CA3228678 A1 CA 3228678A1
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
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- Epidemiology (AREA)
- Zoology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US202163232124P | 2021-08-11 | 2021-08-11 | |
| US63/232,124 | 2021-08-11 | ||
| PCT/US2022/074868 WO2023019223A2 (en) | 2021-08-11 | 2022-08-11 | METHODS OF REDUCING PRODUCTION OF IgA, IgM AND/OR IgG USING sBCMA VARIANTS AND FC FUSION PROTEINS THEREOF |
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| CA3228678A1 true CA3228678A1 (en) | 2023-02-16 |
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| CA3228678A Pending CA3228678A1 (en) | 2021-08-11 | 2022-08-11 | Methods of reducing production of iga, igm and/or igg using sbcma variants and fc fusion proteins thereof |
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| EP (1) | EP4384201A2 (ko) |
| KR (1) | KR20240053675A (ko) |
| AU (1) | AU2022327178A1 (ko) |
| CA (1) | CA3228678A1 (ko) |
| WO (1) | WO2023019223A2 (ko) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999012965A2 (en) | 1997-09-12 | 1999-03-18 | Biogen, Inc. | April- a novel protein with growth effects |
| WO2000012964A1 (fr) | 1998-08-28 | 2000-03-09 | Mitutoyo Corporation | Dispositif et procede d'analyse et de generation d'un programme piece destine aux mesures de coordonnees et de proprietes de surface |
| EP2314694A3 (en) | 1999-08-17 | 2013-12-11 | Biogen Idec MA Inc. | BAFF receptor (BCMA), an immunoregulatory agent |
| UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| BRPI0415709A (pt) * | 2003-10-20 | 2006-12-19 | Biogen Idec Inc | esquemas terapêuticos para antagonistas de baff |
| WO2008119042A2 (en) * | 2007-03-27 | 2008-10-02 | Zymogenetics, Inc. | Combination of blys inhibition and/or april inhibition and immunnosuppressants for treatment of autoimmune disease |
| UA112434C2 (uk) * | 2011-05-27 | 2016-09-12 | Ґлаксо Ґруп Лімітед | Антигензв'язувальний білок, який специфічно зв'язується з всма |
| EP3980538A1 (en) * | 2019-06-04 | 2022-04-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for modulating immunoglobulin expression |
| CN116406371A (zh) * | 2020-08-12 | 2023-07-07 | 斯坦福大学托管董事会 | sBCMA变体及其Fc融合蛋白 |
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| EP4384201A2 (en) | 2024-06-19 |
| AU2022327178A1 (en) | 2024-03-28 |
| WO2023019223A3 (en) | 2023-09-28 |
| WO2023019223A2 (en) | 2023-02-16 |
| KR20240053675A (ko) | 2024-04-24 |
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