CA3214355A1 - Anti-adgre2 antibodies and uses thereof - Google Patents

Anti-adgre2 antibodies and uses thereof Download PDF

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Publication number
CA3214355A1
CA3214355A1 CA3214355A CA3214355A CA3214355A1 CA 3214355 A1 CA3214355 A1 CA 3214355A1 CA 3214355 A CA3214355 A CA 3214355A CA 3214355 A CA3214355 A CA 3214355A CA 3214355 A1 CA3214355 A1 CA 3214355A1
Authority
CA
Canada
Prior art keywords
seq
amino acid
acid sequence
chain variable
region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3214355A
Other languages
English (en)
French (fr)
Inventor
Antara Banerjee
Xingyue He
Shawn JENNINGS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Publication of CA3214355A1 publication Critical patent/CA3214355A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3214355A 2021-04-26 2022-04-25 Anti-adgre2 antibodies and uses thereof Pending CA3214355A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163179756P 2021-04-26 2021-04-26
US63/179,756 2021-04-26
PCT/US2022/026161 WO2022232035A1 (en) 2021-04-26 2022-04-25 Anti-adgre2 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
CA3214355A1 true CA3214355A1 (en) 2022-11-03

Family

ID=81648880

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3214355A Pending CA3214355A1 (en) 2021-04-26 2022-04-25 Anti-adgre2 antibodies and uses thereof

Country Status (17)

Country Link
US (1) US12540178B2 (https=)
EP (1) EP4330283A1 (https=)
JP (1) JP2024518776A (https=)
KR (1) KR20240004287A (https=)
CN (1) CN117580860A (https=)
AR (1) AR125450A1 (https=)
AU (1) AU2022266583A1 (https=)
BR (1) BR112023020371A2 (https=)
CA (1) CA3214355A1 (https=)
CL (1) CL2023003174A1 (https=)
CO (1) CO2023013195A2 (https=)
EC (1) ECSP23088752A (https=)
IL (1) IL307940A (https=)
MX (1) MX2023011712A (https=)
PE (1) PE20242205A1 (https=)
TW (1) TW202305003A (https=)
WO (1) WO2022232035A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023011712A (es) 2021-04-26 2023-10-12 Millennium Pharm Inc Anticuerpos anti receptor de adhesion acoplado a proteinas g e2 (adgre2) y usos de los mismos.
CA3216770A1 (en) 2021-04-26 2022-11-03 Tomoki Yoshihara Anti-clec12a antibodies and uses thereof
CA3212596A1 (en) 2021-04-26 2022-11-03 Michel Sadelain Chimeric receptors targeting adgre2 and/or clec12a and uses thereof
CN120152735A (zh) * 2022-10-25 2025-06-13 武田药品工业株式会社 Adgre2嵌合受体nk细胞组合物和使用方法
WO2024238565A1 (en) * 2023-05-15 2024-11-21 Vor Biopharma Inc. Egf-like module containing mucin-like hormone-like 2 (erm2) binding agents and methods of use thereof
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
WO2025243243A1 (en) * 2024-05-24 2025-11-27 Janssen Biotech, Inc. Bispecific antibody targeting emr2 (cd312) and the t-cell receptor trbv19

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CA3216770A1 (en) 2021-04-26 2022-11-03 Tomoki Yoshihara Anti-clec12a antibodies and uses thereof
CA3212596A1 (en) 2021-04-26 2022-11-03 Michel Sadelain Chimeric receptors targeting adgre2 and/or clec12a and uses thereof
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Also Published As

Publication number Publication date
ECSP23088752A (es) 2024-01-31
CN117580860A (zh) 2024-02-20
BR112023020371A2 (pt) 2024-02-06
WO2022232035A1 (en) 2022-11-03
MX2023011712A (es) 2023-10-12
CO2023013195A2 (es) 2023-10-19
IL307940A (en) 2023-12-01
US20230018888A1 (en) 2023-01-19
AU2022266583A1 (en) 2023-10-19
AU2022266583A9 (en) 2023-10-26
AR125450A1 (es) 2023-07-19
PE20242205A1 (es) 2024-11-19
TW202305003A (zh) 2023-02-01
US12540178B2 (en) 2026-02-03
JP2024518776A (ja) 2024-05-02
CL2023003174A1 (es) 2024-05-24
EP4330283A1 (en) 2024-03-06
KR20240004287A (ko) 2024-01-11

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