ECSP23088752A - Anticuerpos anti-adgre2 y usos de los mismos - Google Patents
Anticuerpos anti-adgre2 y usos de los mismosInfo
- Publication number
- ECSP23088752A ECSP23088752A ECSENADI202388752A ECDI202388752A ECSP23088752A EC SP23088752 A ECSP23088752 A EC SP23088752A EC SENADI202388752 A ECSENADI202388752 A EC SENADI202388752A EC DI202388752 A ECDI202388752 A EC DI202388752A EC SP23088752 A ECSP23088752 A EC SP23088752A
- Authority
- EC
- Ecuador
- Prior art keywords
- antibodies
- adgre2
- fragments
- fusion proteins
- cancers
- Prior art date
Links
- 239000012634 fragment Substances 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 abstract 1
- 102100026402 Adhesion G protein-coupled receptor E2 Human genes 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 101000718211 Homo sapiens Adhesion G protein-coupled receptor E2 Proteins 0.000 abstract 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se describen anticuerpos, fragmentos de los mismos y proteínas de fusión que se unen específicamente a ADGRE2, así como métodos de preparación y uso de tales anticuerpos. Estos anticuerpos, proteínas de fusión y fragmentos de los mismos son de utilidad para el tratamiento y el diagnóstico de diversas enfermedades autoinmunes y cánceres, incluyendo, por ejemplo, leucemia mieloide aguda.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163179756P | 2021-04-26 | 2021-04-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP23088752A true ECSP23088752A (es) | 2024-01-31 |
Family
ID=81648880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSENADI202388752A ECSP23088752A (es) | 2021-04-26 | 2023-11-23 | Anticuerpos anti-adgre2 y usos de los mismos |
Country Status (16)
Country | Link |
---|---|
US (1) | US20230018888A1 (es) |
EP (1) | EP4330283A1 (es) |
JP (1) | JP2024518776A (es) |
KR (1) | KR20240004287A (es) |
CN (1) | CN117580860A (es) |
AR (1) | AR125450A1 (es) |
AU (1) | AU2022266583A1 (es) |
BR (1) | BR112023020371A2 (es) |
CA (1) | CA3214355A1 (es) |
CL (1) | CL2023003174A1 (es) |
CO (1) | CO2023013195A2 (es) |
EC (1) | ECSP23088752A (es) |
IL (1) | IL307940A (es) |
MX (1) | MX2023011712A (es) |
TW (1) | TW202305003A (es) |
WO (1) | WO2022232035A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024089622A1 (en) * | 2022-10-25 | 2024-05-02 | Takeda Pharmaceutical Company Limited | Adgre2 chimeric receptor nk cell compositions and methods of use |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2703893B2 (ja) | 1985-07-05 | 1998-01-26 | ホワイトヘッド・インスティテュ−ト・フォ−・バイオメディカル・リサ−チ | 外来遺伝子物質を発現する上皮細胞 |
US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
EP0378576B1 (en) | 1987-09-11 | 1995-01-18 | Whitehead Institute For Biomedical Research | Transduced fibroblasts and uses therefor |
JP2914692B2 (ja) | 1987-12-11 | 1999-07-05 | ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ | 内皮細胞の遺伝子修飾 |
WO1989007136A2 (en) | 1988-02-05 | 1989-08-10 | Whitehead Institute For Biomedical Research | Modified hepatocytes and uses therefor |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
JP3249516B2 (ja) | 1990-10-31 | 2002-01-21 | ソマティクス セラピー コーポレイション | 遺伝子治療のためのレトロウイルスのベクター |
JPH07503124A (ja) | 1991-06-14 | 1995-04-06 | ゾーマ・コーポレーション | 微生物によって生産される抗体断片とそれらの複合体 |
JP4157160B2 (ja) | 1991-12-13 | 2008-09-24 | ゾーマ テクノロジー リミテッド | 改変抗体可変領域の調製のための方法 |
SE9201984D0 (sv) | 1992-06-29 | 1992-06-29 | Pharmacia Biosensor Ab | Improvement in optical assays |
US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
US5308341A (en) | 1993-09-28 | 1994-05-03 | Becton, Dickinson And Company | Method of testing the dose accuracy of a medication delivery device |
US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
US5773019A (en) | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
US6146361A (en) | 1996-09-26 | 2000-11-14 | Becton Dickinson And Company | Medication delivery pen having a 31 gauge needle |
US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
US7227002B1 (en) | 1997-04-14 | 2007-06-05 | Micromet Ag | Human antibodies that bind human 17-A1/EpCAM tumor antigen |
AU7467898A (en) | 1997-04-21 | 1998-11-13 | Arch Development Corporation | Fc receptor non-binding anti-cd3 monoclonal antibodies deliver a partial cr signal and induce clonal anergy |
US6302855B1 (en) | 1998-05-20 | 2001-10-16 | Novo Nordisk A/S | Medical apparatus for use by a patient for medical self treatment of diabetes |
US6192891B1 (en) | 1999-04-26 | 2001-02-27 | Becton Dickinson And Company | Integrated system including medication delivery pen, blood monitoring device, and lancer |
US6277099B1 (en) | 1999-08-06 | 2001-08-21 | Becton, Dickinson And Company | Medication delivery pen |
PE20011227A1 (es) | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
US6719750B2 (en) | 2000-08-30 | 2004-04-13 | The Johns Hopkins University | Devices for intraocular drug delivery |
DK1355919T3 (da) | 2000-12-12 | 2011-03-14 | Medimmune Llc | Molekyler med længere halveringstider, sammensætninger og anvendelser deraf |
CN100349629C (zh) | 2001-09-12 | 2007-11-21 | 贝克顿迪肯森公司 | 用于药物传送的微针为基础的笔装置和使用该装置的方法 |
US20050271660A1 (en) | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
US20040102469A1 (en) | 2002-09-13 | 2004-05-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method for reducing the mortality rate |
GB0222023D0 (en) | 2002-09-21 | 2002-10-30 | Aventis Pharma Ltd | Inhaler |
FR2849436B1 (fr) | 2002-12-27 | 2007-01-05 | Patrick Frayssinet | Particules et ceramiques de phosphates de calcium pour transfection in vivo et in vitro |
WO2004073551A2 (en) | 2003-02-18 | 2004-09-02 | Massachusetts Eye And Ear Infirmary | Transscleral drug delivery device and related methods |
WO2006130834A2 (en) | 2005-05-31 | 2006-12-07 | Board Of Regents, The University Of Texas System | IGGl ANTIBODIES WITH MUTATED FC PORTION FOR INCREASED BINDING TO FCRN RECEPTOR AND USES THEREOF |
CA2693771A1 (en) | 2007-07-13 | 2009-01-22 | Abbott Biotechnology Ltd. | Methods and compositions for pulmonary administration of a tnf.alpha. inhibitor |
EP2545079A2 (en) | 2010-03-11 | 2013-01-16 | Rinat Neuroscience Corporation | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING |
EP2622074B1 (en) | 2010-09-30 | 2014-11-12 | Board Of Trustees Of Northern Illinois University | Library-based methods and compositions for introducing molecular switch functionality into protein affinity reagents |
JP6296536B2 (ja) * | 2010-11-05 | 2018-03-20 | メドベット サイエンス ピーティーワイエルティーディーMedvet Science Pty Ltd | 内皮前駆細胞のマーカーおよびその使用 |
WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
MA43282A (fr) * | 2015-11-19 | 2018-09-26 | Abbvie Stemcentrx Llc | Nouveaux anticorps anti-emr2 et méthodes d'utilisation associées |
CA3000514A1 (en) * | 2016-08-04 | 2018-02-08 | Memorial Sloan-Kettering Cancer Center | Cancer antigen targets and uses thereof |
-
2022
- 2022-04-25 WO PCT/US2022/026161 patent/WO2022232035A1/en active Application Filing
- 2022-04-25 BR BR112023020371A patent/BR112023020371A2/pt unknown
- 2022-04-25 KR KR1020237034369A patent/KR20240004287A/ko unknown
- 2022-04-25 US US17/728,598 patent/US20230018888A1/en active Pending
- 2022-04-25 CN CN202280030498.9A patent/CN117580860A/zh active Pending
- 2022-04-25 EP EP22723302.0A patent/EP4330283A1/en active Pending
- 2022-04-25 JP JP2023565453A patent/JP2024518776A/ja active Pending
- 2022-04-25 MX MX2023011712A patent/MX2023011712A/es unknown
- 2022-04-25 CA CA3214355A patent/CA3214355A1/en active Pending
- 2022-04-25 IL IL307940A patent/IL307940A/en unknown
- 2022-04-25 TW TW111115646A patent/TW202305003A/zh unknown
- 2022-04-25 AU AU2022266583A patent/AU2022266583A1/en active Pending
- 2022-04-25 AR ARP220101068A patent/AR125450A1/es unknown
-
2023
- 2023-10-03 CO CONC2023/0013195A patent/CO2023013195A2/es unknown
- 2023-10-24 CL CL2023003174A patent/CL2023003174A1/es unknown
- 2023-11-23 EC ECSENADI202388752A patent/ECSP23088752A/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX2023011712A (es) | 2023-10-12 |
CO2023013195A2 (es) | 2023-10-19 |
IL307940A (en) | 2023-12-01 |
CL2023003174A1 (es) | 2024-05-24 |
EP4330283A1 (en) | 2024-03-06 |
WO2022232035A1 (en) | 2022-11-03 |
CA3214355A1 (en) | 2022-11-03 |
AU2022266583A9 (en) | 2023-10-26 |
AU2022266583A1 (en) | 2023-10-19 |
AR125450A1 (es) | 2023-07-19 |
KR20240004287A (ko) | 2024-01-11 |
CN117580860A (zh) | 2024-02-20 |
JP2024518776A (ja) | 2024-05-02 |
TW202305003A (zh) | 2023-02-01 |
BR112023020371A2 (pt) | 2024-02-06 |
US20230018888A1 (en) | 2023-01-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2019013611A2 (es) | Anticuerpos específicos para flt3 y sus usos | |
ECSP20082991A (es) | Agentes aglutinantes del psma y usos de estos | |
UY37698A (es) | Proteínas de unión a antígenos trem2 y usos de estas | |
CO2020000214A2 (es) | Anticuerpos agonistas que se unen a cd137 humano y sus usos | |
ECSP18096095A (es) | Anticuerpos a la alfa-sinucleína y usos de los mismos | |
ECSP23088752A (es) | Anticuerpos anti-adgre2 y usos de los mismos | |
UY35258A (es) | ANTICUERPOS ANTI-PDGFR-beta Y USOS DE LOS MISMOS | |
UY38242A (es) | Anticuerpos anti-cd33, anticuerpos bioespecíficos anti- cd33/anti-cd3 y usos de éstos | |
CO2017002719A2 (es) | Anticuerpos anti-glucagón | |
UY32812A (es) | Anticuerpos humanos de alta afinidad para angiopoyetina -2 humana. | |
CR20170059A (es) | ANTICUERPOS Anti-LAG3 Y FRAGMENTOS DE UNIÓN A ANTÍGENO | |
UY37591A (es) | Conjugados de fármaco anticuerpo | |
PE20220142A1 (es) | Anticuerpos de cadena pesada que se unen al psma | |
UY35712A (es) | Anticuerpos anti-prlr y uso de los mismos | |
UY35042A (es) | Anticuerpos anti-cd3, moléculas de unión a antígeno biespecíficas que se unen a cd3 y cd20, y usos de los mismos. | |
CL2020002144A1 (es) | Proteínas de unión multiespecíficas que se unen a cd33, nkg2d y cd16 y métodos de uso, (solic. hna 2143) | |
CO2020009402A2 (es) | Proteínas de fusión fc il-22 y métodos de uso | |
UY36942A (es) | Proteínas de unión a antígeno que activan el receptor de leptina | |
CO2020005347A2 (es) | Anticuerpos y conjugados de anticuerpo-fármaco específicos para cd123 y usos de los mismos | |
CO2018012497A2 (es) | Anticuerpos de interferón beta y usos de los mismos | |
UY36706A (es) | Anticuerpos dirigidos a la proteína morfogenética ósea 9 (bmp9) y métodos a partir de estos | |
EA202092302A1 (ru) | Антитела к trem-1 и их применения | |
ECSP20039728A (es) | Anticuerpos monoclonales y métodos para utilizar los mismos | |
CO2024004055A2 (es) | Polipéptidos | |
CO2023014316A2 (es) | Anticuerpos anti-clec12a y usos de los mismos |