CA3200564A1 - Oral delivery of antisense conjugates targeting pcsk9 - Google Patents

Oral delivery of antisense conjugates targeting pcsk9

Info

Publication number
CA3200564A1
CA3200564A1 CA3200564A CA3200564A CA3200564A1 CA 3200564 A1 CA3200564 A1 CA 3200564A1 CA 3200564 A CA3200564 A CA 3200564A CA 3200564 A CA3200564 A CA 3200564A CA 3200564 A1 CA3200564 A1 CA 3200564A1
Authority
CA
Canada
Prior art keywords
pharmaceutical composition
aspects
oligomer
capsule
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3200564A
Other languages
English (en)
French (fr)
Inventor
Henrik Oerum
Stewart Alwyn Noble
Charles Lester Shear
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Civi Biopharma Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA3200564A1 publication Critical patent/CA3200564A1/en
Pending legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A—HUMAN NECESSITIES
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
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    • C12Y304/21061—Kexin (3.4.21.61), i.e. proprotein convertase subtilisin/kexin type 9

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CA3200564A 2020-12-11 2021-12-10 Oral delivery of antisense conjugates targeting pcsk9 Pending CA3200564A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202063124581P 2020-12-11 2020-12-11
US63/124,581 2020-12-11
US202163134884P 2021-01-07 2021-01-07
US63/134,884 2021-01-07
US202163178340P 2021-04-22 2021-04-22
US63/178,340 2021-04-22
US202163261505P 2021-09-22 2021-09-22
US63/261,505 2021-09-22
PCT/US2021/062831 WO2022125913A1 (en) 2020-12-11 2021-12-10 Oral delivery of antisense conjugates targeting pcsk9

Publications (1)

Publication Number Publication Date
CA3200564A1 true CA3200564A1 (en) 2022-06-16

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CA3200564A Pending CA3200564A1 (en) 2020-12-11 2021-12-10 Oral delivery of antisense conjugates targeting pcsk9

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US (3) US20240067965A1 (enExample)
EP (1) EP4259799A4 (enExample)
JP (1) JP2024500367A (enExample)
KR (1) KR20230132442A (enExample)
AU (1) AU2021396376A1 (enExample)
CA (1) CA3200564A1 (enExample)
CL (1) CL2023001639A1 (enExample)
CO (1) CO2023009176A2 (enExample)
CR (1) CR20230308A (enExample)
IL (1) IL303462A (enExample)
MX (1) MX2023006711A (enExample)
PE (1) PE20240887A1 (enExample)
TW (1) TW202237846A (enExample)
UA (1) UA130263C2 (enExample)
WO (1) WO2022125913A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20230308A (es) 2020-12-11 2023-09-08 Civi Biopharma Inc Entrega oral de conjugados antisentido que tienen por blanco a pcsk9
CR20230471A (es) * 2021-04-22 2023-11-01 Civi Biopharma Inc Administración oral de oligonucleótidos
WO2023065231A1 (en) * 2021-10-21 2023-04-27 Guangzhou Dazhou Biomedicine Ltd. Oral delivery of therapeutic agents

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