CA3199736A1 - Formulations and methods for treating conditions of the eye - Google Patents

Formulations and methods for treating conditions of the eye

Info

Publication number
CA3199736A1
CA3199736A1 CA3199736A CA3199736A CA3199736A1 CA 3199736 A1 CA3199736 A1 CA 3199736A1 CA 3199736 A CA3199736 A CA 3199736A CA 3199736 A CA3199736 A CA 3199736A CA 3199736 A1 CA3199736 A1 CA 3199736A1
Authority
CA
Canada
Prior art keywords
pharmaceutical formulation
administered
azithromycin
sub
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3199736A
Other languages
English (en)
French (fr)
Inventor
Paul Badawi
David Y. Badawi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sight Sciences Inc
Original Assignee
Sight Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sight Sciences Inc filed Critical Sight Sciences Inc
Publication of CA3199736A1 publication Critical patent/CA3199736A1/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/194Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3199736A 2020-11-23 2021-11-23 Formulations and methods for treating conditions of the eye Pending CA3199736A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063117393P 2020-11-23 2020-11-23
US63/117,393 2020-11-23
US202163254958P 2021-10-12 2021-10-12
US63/254,958 2021-10-12
PCT/US2021/060653 WO2022109497A1 (en) 2020-11-23 2021-11-23 Formulations and methods for treating conditions of the eye

Publications (1)

Publication Number Publication Date
CA3199736A1 true CA3199736A1 (en) 2022-05-27

Family

ID=81658809

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3199736A Pending CA3199736A1 (en) 2020-11-23 2021-11-23 Formulations and methods for treating conditions of the eye

Country Status (6)

Country Link
US (5) US20220160668A1 (enExample)
EP (1) EP4247367A4 (enExample)
JP (1) JP2023550632A (enExample)
AU (1) AU2021381495A1 (enExample)
CA (1) CA3199736A1 (enExample)
WO (1) WO2022109497A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2961369T3 (es) 2012-03-20 2024-03-11 Sight Sciences Inc Sistemas de entrega ocular
US10299958B2 (en) 2015-03-31 2019-05-28 Sight Sciences, Inc. Ocular delivery systems and methods
US11504270B1 (en) 2019-09-27 2022-11-22 Sight Sciences, Inc. Ocular delivery systems and methods
US20220160668A1 (en) 2020-11-23 2022-05-26 Sight Sciences, Inc. Formulations and methods for treating conditions of the eye
WO2022251710A2 (en) 2021-05-28 2022-12-01 Sight Sciences, Inc. Intraocular devices, systems, and methods
WO2023177761A2 (en) 2022-03-16 2023-09-21 Sight Sciences, Inc. Devices and methods for intraocular tissue manipulation
AU2023270196B2 (en) * 2023-11-20 2025-06-26 Dyer, Gordon Wayne DR Method of Arthropod Egress

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957918A (en) 1988-06-09 1990-09-18 Leonard Bloom Topical treatment of blepharitis
US5614545A (en) 1988-06-09 1997-03-25 Leonard Bloom Topical composition for treatment of blepharitis
AT393454B (de) * 1989-10-04 1991-10-25 Ido Dr Egerer Augentropfenzusatz
US6107289A (en) 1992-04-21 2000-08-22 The Schepens Eye Research Institute, Inc. Ocular therapy in keratoconjunctivitis sicca using topically applied androgens or TGF-β
US6239113B1 (en) * 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
PL368642A1 (en) 2001-11-19 2005-04-04 Novartis Ag Use of an ascomycin for the treatment of blepharitis
WO2004062669A1 (en) 2003-01-16 2004-07-29 Sucampo Ag Use of a macrolide compound for treating dry eye
KR20050092429A (ko) 2003-01-22 2005-09-21 니찌방 가부시기가이샤 안질환 치료용 경피 흡수형 제제, 그 사용, 및 안질환치료약의 눈의 국소 조직으로의 이행 방법
CN101123948A (zh) 2005-02-17 2008-02-13 千寿制药株式会社 眼科用固体外用药剂
WO2007005421A2 (en) 2005-07-01 2007-01-11 Bausch & Lomb Incorporated Long lasting alginate dry eye, related methods of manufacture and methods of use
FR2891460B1 (fr) * 2005-09-30 2010-07-30 Galderma Sa Utilisation d'au moins un compose de la famille des avermectines pour le traitement des pathologies ophtalmiques dues au demodex folliculorum.
JP5186217B2 (ja) 2005-11-28 2013-04-17 千寿製薬株式会社 Pparアゴニスト含有医薬
EP2056809A1 (en) 2006-08-28 2009-05-13 Senju Pharmaceutical Co., Ltd. Ophthalmic percutaneous absorption type preparation
US20080057022A1 (en) 2006-08-30 2008-03-06 Erning Xia Ophthalmic Pharmaceutical Compositions and Uses Thereof
US7659259B2 (en) 2006-12-21 2010-02-09 Bausch & Lomb Incorporated Method of treating inflammation of the eye
BRPI0808410A2 (pt) 2007-02-28 2015-06-23 Aciex Therapeutics Inc Métodos e composições para normalizar secreções da glândula meibomiana
WO2008137496A1 (en) * 2007-05-04 2008-11-13 Bausch & Lomb Incorporated Compositions for reducing, ameliorating, treating, or preventing condition of dry eye and methods of making and using same
CN101754745A (zh) 2007-05-07 2010-06-23 博士伦公司 用于缓解、改善、治疗或预防干眼症的组合物及其制备和使用方法
WO2009111648A1 (en) 2008-03-05 2009-09-11 Vicus Therapeutics, Llc Compositions and methods for mucositis and oncology therapies
WO2009120881A1 (en) 2008-03-26 2009-10-01 Eric Donnenfeld Methods for improving lid margin and tear film function and treatment of lid margin desease using tetracycline family antibiotics
JP2011527709A (ja) * 2008-07-10 2011-11-04 インスパイアー ファーマシューティカルズ,インコーポレイティド 眼瞼炎の治療方法
EP2393355A4 (en) * 2009-01-23 2012-07-25 Inspire Pharmaceuticals Inc METHOD FOR TREATING A DRY EYE WITH AZITHROMYCIN
FR2942138A1 (fr) 2009-02-16 2010-08-20 Galderma Res & Dev Association de composes pour le traitement ou la prevention des affections dermatologiques
US9034830B2 (en) 2009-10-30 2015-05-19 Intratus, Inc. Methods and compositions for sustained delivery of drugs
US20110294897A1 (en) 2009-12-02 2011-12-01 Bridge Pharma, Inc. Treating Xerophthalmia With Compounds Increasing Meibomian Gland Secretion
WO2011106697A1 (en) * 2010-02-25 2011-09-01 Schepens Eye Research Institute Therapeutic compositions for the treatment of dry eye disease
CN103140217B (zh) 2010-08-06 2015-08-19 盖尔德马研究及发展公司 用于治疗或预防皮肤病的化合物的组合
US20130281390A1 (en) * 2010-12-29 2013-10-24 Kurt E. Brubaker Method for treating dry eye
US8900626B2 (en) 2011-06-20 2014-12-02 Senju Usa, Inc. Transdermal drug delivery system and method of using the same
CA2840626A1 (en) 2011-06-29 2013-01-03 Insite Vision Incorporated Methods of treating recurrent meibomian glands disorder and thereby decreasing the frequency of recurrence
JP5989780B2 (ja) * 2011-09-14 2016-09-07 フォーサイト・ビジョン5・インコーポレイテッドForsight Vision5,Inc. 眼挿入装置および方法
CN113679699B (zh) 2012-09-12 2022-10-28 诺瓦利克有限责任公司 包含半氟化烷烃的混合物的组合物
AU2013314303B2 (en) 2012-09-12 2018-01-18 Novaliq Gmbh Semifluorinated alkane compositions
KR20160032260A (ko) 2012-09-28 2016-03-23 산텐 세이야꾸 가부시키가이샤 마이봄샘 기능 부전 또는 마이봄샘 경색의 치료제 또는 예방제
US9044508B2 (en) 2013-03-15 2015-06-02 Insite Vision Corporation Concentrated aqueous azalide formulations
US20150141328A1 (en) * 2013-11-18 2015-05-21 The Schepens Eye Research Institute Stimulation of human meibomian gland function
WO2016022066A1 (en) 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
US9931306B2 (en) * 2014-09-06 2018-04-03 Integral Biosystems Llc Methods and biocompatible compositions to achieve sustained drug release in the eye
MX2017010544A (es) 2015-02-24 2018-06-18 Univ Illinois Metodos y composiciones para tratar la enfermedad del ojo seco y otros trastornos del ojo.
US9393243B1 (en) 2015-07-14 2016-07-19 Nilesh Parikh Topical Ciprofloxacin compositions
US10688122B2 (en) 2015-09-28 2020-06-23 Azura Ophthalmics Ltd. Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion
FR3041540B1 (fr) 2015-09-29 2018-10-26 Galderma Research & Development Composition nettoyante auto-moussante a rincer, contenant de l'ivermectine.
WO2017089980A1 (en) 2015-11-26 2017-06-01 Cadila Healthcare Limited Dual ppar modulators for the treatment of diabetic retinopathy and diabetic eye diseases
GB201522144D0 (en) 2015-12-15 2016-01-27 Univ Manchester Compositions and uses and methods relating thereto
US9439917B1 (en) 2015-12-28 2016-09-13 Shetal Amit Shah Anti-blepharitis compositions and their use
CA3021394C (en) 2016-02-04 2021-12-28 Gordon Wayne Dyer Method for breaching an oleo and hydro resistant arthropod plastron by applying a low molecular weight non-polar chemical breacher to the plastron
US11260035B2 (en) 2016-10-12 2022-03-01 Ps Therapies Ltd Topical compositions and methods of use thereof
EP3326608A1 (en) 2016-11-24 2018-05-30 Nestlé Skin Health SA Composition comprising avermectin compounds without solid fatty substances
GB201706969D0 (en) 2017-05-02 2017-06-14 Medherant Ltd Formulation
US20190008920A1 (en) * 2017-05-19 2019-01-10 Ocugen, Inc. Ophthalmic compositions and methods of use
JP2020525416A (ja) 2017-06-29 2020-08-27 アドヴァイテ エルエルシー. 眼表面障害の治療及び診断
AU2018372185B2 (en) 2017-11-21 2024-05-16 Cs Pharmaceuticals Limited Compositions and methods of use for treating aberrant inflammation in peri-ocular secretory glands or at the ocular surface
WO2019113475A1 (en) 2017-12-07 2019-06-13 Dermavant Sciences GmbH Topical ointment formulations and their use in treating skin conditions
US20230165798A1 (en) 2018-10-12 2023-06-01 Hovione Scientia Macrocyclic lactone formulations, methods of their preparation and use of the formulations in treating pathologies secondary to ophthalmic parasites
US12161752B2 (en) * 2019-08-20 2024-12-10 Vishwanath Padmanabhan Compositions and methods for the treatment of anterior blepharitis and posterior blepharitis
US20210052493A1 (en) 2019-08-21 2021-02-25 Joseph Sinclair Non-aqueous anti-parasitic ointment for ophthalmological use
US20220347167A1 (en) 2019-10-05 2022-11-03 The Schepens Eye Research Institute, Inc. A new treatment for meibomian gland dysfunction
WO2021087051A1 (en) 2019-10-30 2021-05-06 Ps Therapy Ltd. Topical compositions and methods of use thereof
US20220160668A1 (en) 2020-11-23 2022-05-26 Sight Sciences, Inc. Formulations and methods for treating conditions of the eye
US11872213B2 (en) 2021-01-28 2024-01-16 Glaukos Corporation Formulations

Also Published As

Publication number Publication date
US20220160668A1 (en) 2022-05-26
US20230210878A1 (en) 2023-07-06
US20240415860A1 (en) 2024-12-19
US20220160743A1 (en) 2022-05-26
AU2021381495A1 (en) 2023-06-22
WO2022109497A1 (en) 2022-05-27
US11925657B2 (en) 2024-03-12
EP4247367A4 (en) 2024-10-16
JP2023550632A (ja) 2023-12-04
EP4247367A1 (en) 2023-09-27
US11554134B2 (en) 2023-01-17
US11419886B2 (en) 2022-08-23
US20220354878A1 (en) 2022-11-10

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