CA3197024A1 - Chimeric protein comprising the receptor binding domain of the coronavirus spike protein and compositions thereof - Google Patents

Chimeric protein comprising the receptor binding domain of the coronavirus spike protein and compositions thereof

Info

Publication number
CA3197024A1
CA3197024A1 CA3197024A CA3197024A CA3197024A1 CA 3197024 A1 CA3197024 A1 CA 3197024A1 CA 3197024 A CA3197024 A CA 3197024A CA 3197024 A CA3197024 A CA 3197024A CA 3197024 A1 CA3197024 A1 CA 3197024A1
Authority
CA
Canada
Prior art keywords
hbcag
crbdh6
protein
rbd
segment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3197024A
Other languages
English (en)
French (fr)
Inventor
Glay Chinea Santiago
Alejandro Miguel Martin Dunn
Diamile Gonzalez Roche
Miladys Limonta Fernandez
Enrique Iglesias Perez
Monica Bequet Romero
Hector Santana Milian
Gabriel J. Marquez Perera
Alexis Musacchio Lasa
Ania Cabrales Rico
Gerardo Enrique Guillen Nieto
Marta Ayala Avila
Eulogio Pimentel Vazquez
Gertrudis Rojas Dorantes
Vivian Huerta Galindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Center for Genetic Engineering and Biotechnology
Original Assignee
Center for Genetic Engineering and Biotechnology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Center for Genetic Engineering and Biotechnology filed Critical Center for Genetic Engineering and Biotechnology
Publication of CA3197024A1 publication Critical patent/CA3197024A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20071—Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3197024A 2020-11-04 2021-11-03 Chimeric protein comprising the receptor binding domain of the coronavirus spike protein and compositions thereof Pending CA3197024A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CU2020-0081 2020-11-04
CU2020000081A CU24665B1 (es) 2020-11-04 2020-11-04 Proteína quimérica que comprende el dominio de unión al receptor de la proteína de la espiga de coronavirus y composiciones que las comprenden
PCT/CU2021/050010 WO2022096039A1 (es) 2020-11-04 2021-11-03 Proteina quimerica que comprende el dominio de union al receptor de la proteina de la espiga de corona virus y composiciones que las comprenden

Publications (1)

Publication Number Publication Date
CA3197024A1 true CA3197024A1 (en) 2022-05-12

Family

ID=79164940

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3197024A Pending CA3197024A1 (en) 2020-11-04 2021-11-03 Chimeric protein comprising the receptor binding domain of the coronavirus spike protein and compositions thereof

Country Status (12)

Country Link
US (1) US20230405106A1 (enExample)
EP (1) EP4242222A1 (enExample)
JP (1) JP2023548205A (enExample)
CN (1) CN116802194A (enExample)
AR (1) AR123998A1 (enExample)
AU (1) AU2021373188A1 (enExample)
CA (1) CA3197024A1 (enExample)
CO (1) CO2023004963A2 (enExample)
CU (1) CU24665B1 (enExample)
MX (1) MX2023005211A (enExample)
WO (1) WO2022096039A1 (enExample)
ZA (1) ZA202304779B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7887978B2 (ja) * 2022-05-23 2026-07-10 バクスディグム カンパニー，リミティド ウイルスヌクレオカプシドを用いた結晶性タンパク質ベースの標的タンパク質融合自己組織化ナノ粒子製造プラットフォーム
KR102617592B1 (ko) * 2022-05-23 2023-12-29 주식회사 백스다임 바이러스 뉴클레오캡시드를 이용한 오량체형 독소 단백질 기반 목적 단백질 융합 오량체 제조 플랫폼

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111217918B (zh) * 2020-03-04 2020-11-10 中山大学 一种基于2,4-二氧四氢喋啶合酶的新型冠状病毒s蛋白双区域亚单位纳米疫苗
CN111366734B (zh) * 2020-03-20 2021-07-13 广州市康润生物科技有限公司 双指标筛选新冠病毒及预判重型肺炎的方法
CN111620952A (zh) * 2020-06-17 2020-09-04 苏州米迪生物技术有限公司 基于嵌合型病毒样颗粒的新型冠状病毒疫苗
CN111676248A (zh) * 2020-07-02 2020-09-18 军事科学院军事医学研究院军事兽医研究所 表达新型冠状病毒S基因与流感M1基因嵌合SARS-CoV-2 VLP的构建

Also Published As

Publication number Publication date
JP2023548205A (ja) 2023-11-15
ZA202304779B (en) 2024-09-25
CO2023004963A2 (es) 2023-06-20
CU24665B1 (es) 2023-06-13
CU20200081A7 (es) 2022-06-06
AU2021373188A1 (en) 2023-06-01
CN116802194A (zh) 2023-09-22
AR123998A1 (es) 2023-02-01
US20230405106A1 (en) 2023-12-21
WO2022096039A1 (es) 2022-05-12
EP4242222A1 (en) 2023-09-13
AU2021373188A9 (en) 2024-10-10
MX2023005211A (es) 2023-05-16

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