CA3188313A1 - Compounds for targeted degradation of ret - Google Patents
Compounds for targeted degradation of retInfo
- Publication number
- CA3188313A1 CA3188313A1 CA3188313A CA3188313A CA3188313A1 CA 3188313 A1 CA3188313 A1 CA 3188313A1 CA 3188313 A CA3188313 A CA 3188313A CA 3188313 A CA3188313 A CA 3188313A CA 3188313 A1 CA3188313 A1 CA 3188313A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- alkyl
- ret
- aryl
- heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063061741P | 2020-08-05 | 2020-08-05 | |
| US63/061,741 | 2020-08-05 | ||
| US202163136586P | 2021-01-12 | 2021-01-12 | |
| US63/136,586 | 2021-01-12 | ||
| PCT/US2021/044838 WO2022032026A1 (en) | 2020-08-05 | 2021-08-05 | Compounds for targeted degradation of ret |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3188313A1 true CA3188313A1 (en) | 2022-02-10 |
Family
ID=80118572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3188313A Pending CA3188313A1 (en) | 2020-08-05 | 2021-08-05 | Compounds for targeted degradation of ret |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230233692A1 (https=) |
| EP (1) | EP4192458A4 (https=) |
| JP (1) | JP2023538517A (https=) |
| CN (1) | CN116490186B (https=) |
| CA (1) | CA3188313A1 (https=) |
| IL (1) | IL300397A (https=) |
| WO (1) | WO2022032026A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| TW202146412A (zh) | 2020-03-05 | 2021-12-16 | 美商Ｃ４醫藥公司 | 用於標靶降解brd9之化合物 |
| WO2024030968A1 (en) * | 2022-08-03 | 2024-02-08 | Brystol-Myers Squibb Company | Compounds for modulating ret protein |
| WO2024073507A1 (en) | 2022-09-28 | 2024-04-04 | Theseus Pharmaceuticals, Inc. | Macrocyclic compounds and uses thereof |
| WO2024158759A2 (en) * | 2023-01-23 | 2024-08-02 | Purdue Research Foundation | Inhibitors of solvent front mutated ret kinase |
| KR20250145679A (ko) * | 2023-02-16 | 2025-10-13 | 브리스톨-마이어스 스큅 컴퍼니 | Ret 키나제의 분해제로서의 이소인돌리논 글루타르이미드 및 페닐 글루타르이미드 유사체 |
| TW202502750A (zh) | 2023-06-08 | 2025-01-16 | 美商新銳思生物製藥股份有限公司 | Smarca2之雙官能選擇性降解劑及其治療用途 |
| EP4735452A2 (en) | 2023-06-30 | 2026-05-06 | Merck Patent GmbH | Heterobifunctional compounds for the degradation of kras protein |
| EP4735438A2 (en) | 2023-06-30 | 2026-05-06 | Merck Patent GmbH | Heterobifunctional compounds for the degradation of kras |
| CN117003681A (zh) * | 2023-07-04 | 2023-11-07 | 苏州汉德创宏生化科技有限公司 | 一种抑制剂类中间体及其合成方法 |
| WO2025062330A1 (en) | 2023-09-20 | 2025-03-27 | Aurigene Oncology Limited | Heterocyclic compounds as cbp selective degraders |
| TW202535377A (zh) * | 2023-12-22 | 2025-09-16 | 美商Ｃ４醫藥公司 | 用於標靶降解原癌基因酪胺酸蛋白質激酶受體（ｒｅｔ）之化合物 |
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2021
- 2021-08-05 IL IL300397A patent/IL300397A/en unknown
- 2021-08-05 CN CN202180068438.1A patent/CN116490186B/zh active Active
- 2021-08-05 JP JP2023507866A patent/JP2023538517A/ja active Pending
- 2021-08-05 EP EP21854440.1A patent/EP4192458A4/en active Pending
- 2021-08-05 WO PCT/US2021/044838 patent/WO2022032026A1/en not_active Ceased
- 2021-08-05 CA CA3188313A patent/CA3188313A1/en active Pending
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| US20230233692A1 (en) | 2023-07-27 |
| EP4192458A4 (en) | 2024-09-04 |
| JP2023538517A (ja) | 2023-09-08 |
| CN116490186B (zh) | 2025-10-31 |
| CN116490186A (zh) | 2023-07-25 |
| EP4192458A1 (en) | 2023-06-14 |
| WO2022032026A1 (en) | 2022-02-10 |
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