CA3188286A1 - Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate and methods of synthesis - Google Patents
Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate and methods of synthesisInfo
- Publication number
- CA3188286A1 CA3188286A1 CA3188286A CA3188286A CA3188286A1 CA 3188286 A1 CA3188286 A1 CA 3188286A1 CA 3188286 A CA3188286 A CA 3188286A CA 3188286 A CA3188286 A CA 3188286A CA 3188286 A1 CA3188286 A1 CA 3188286A1
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- CA
- Canada
- Prior art keywords
- compound
- formula
- composition
- free base
- crystal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063046120P | 2020-06-30 | 2020-06-30 | |
| US202063046123P | 2020-06-30 | 2020-06-30 | |
| US63/046,123 | 2020-06-30 | ||
| US63/046,120 | 2020-06-30 | ||
| PCT/US2021/039305 WO2022005928A1 (en) | 2020-06-30 | 2021-06-28 | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin -1-yl]ethyl pyridine-3-carboxylate and methods of synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3188286A1 true CA3188286A1 (en) | 2022-01-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3188286A Pending CA3188286A1 (en) | 2020-06-30 | 2021-06-28 | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate and methods of synthesis |
Country Status (8)
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|---|---|
| EP (1) | EP4171233A4 (zh) |
| JP (1) | JP2023532330A (zh) |
| KR (1) | KR20230031320A (zh) |
| CN (1) | CN116056711A (zh) |
| AU (1) | AU2021299266A1 (zh) |
| CA (1) | CA3188286A1 (zh) |
| IL (1) | IL299547A (zh) |
| WO (1) | WO2022005928A1 (zh) |
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| WO2023235297A1 (en) * | 2022-06-03 | 2023-12-07 | Imbria Pharmaceuticals, Inc. | Compounds and methods for increasing efficiency of cardiac metabolism |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9169279B2 (en) * | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| CN102850296B (zh) * | 2012-09-29 | 2015-01-07 | 瑞阳制药有限公司 | 曲美他嗪的制备方法 |
| AU2018289303B2 (en) * | 2017-06-20 | 2023-12-21 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
| WO2020243120A1 (en) * | 2019-05-31 | 2020-12-03 | Imbria Pharmaceuticals, Inc. | Methods of treating fibrosis using compounds that promote glucose oxidation |
| WO2020243119A1 (en) * | 2019-05-31 | 2020-12-03 | Imbria Pharmaceuticals, Inc. | Methods of altering cardiac remodeling using compounds that promote glucose oxidation |
-
2021
- 2021-06-28 WO PCT/US2021/039305 patent/WO2022005928A1/en unknown
- 2021-06-28 AU AU2021299266A patent/AU2021299266A1/en active Pending
- 2021-06-28 EP EP21833175.9A patent/EP4171233A4/en active Pending
- 2021-06-28 CA CA3188286A patent/CA3188286A1/en active Pending
- 2021-06-28 IL IL299547A patent/IL299547A/en unknown
- 2021-06-28 CN CN202180056396.XA patent/CN116056711A/zh active Pending
- 2021-06-28 JP JP2022581465A patent/JP2023532330A/ja active Pending
- 2021-06-28 KR KR1020237003155A patent/KR20230031320A/ko active Search and Examination
Also Published As
| Publication number | Publication date |
|---|---|
| CN116056711A (zh) | 2023-05-02 |
| WO2022005928A1 (en) | 2022-01-06 |
| EP4171233A1 (en) | 2023-05-03 |
| AU2021299266A1 (en) | 2023-02-02 |
| EP4171233A4 (en) | 2024-08-21 |
| KR20230031320A (ko) | 2023-03-07 |
| JP2023532330A (ja) | 2023-07-27 |
| IL299547A (en) | 2023-02-01 |
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