CA3174980A1 - New anti-malarial agents - Google Patents

New anti-malarial agents

Info

Publication number
CA3174980A1
CA3174980A1 CA3174980A CA3174980A CA3174980A1 CA 3174980 A1 CA3174980 A1 CA 3174980A1 CA 3174980 A CA3174980 A CA 3174980A CA 3174980 A CA3174980 A CA 3174980A CA 3174980 A1 CA3174980 A1 CA 3174980A1
Authority
CA
Canada
Prior art keywords
oxo
trifluoroethyl
iii
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3174980A
Other languages
English (en)
French (fr)
Inventor
Rodney Kiplin Guy
Jared T. Hammill
David Floyd
Jeremy Burrows
Stephen Brand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MMV Medicines for Malaria Venture
University of Kentucky Research Foundation
Original Assignee
MMV Medicines for Malaria Venture
University of Kentucky Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MMV Medicines for Malaria Venture, University of Kentucky Research Foundation filed Critical MMV Medicines for Malaria Venture
Publication of CA3174980A1 publication Critical patent/CA3174980A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3174980A 2020-04-09 2021-04-08 New anti-malarial agents Pending CA3174980A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063007385P 2020-04-09 2020-04-09
US63/007,385 2020-04-09
EP20169099.7 2020-04-09
EP20169099.7A EP3892332A1 (en) 2020-04-09 2020-04-09 New anti-malarial agents
PCT/EP2021/059196 WO2021204952A1 (en) 2020-04-09 2021-04-08 New anti-malarial agents

Publications (1)

Publication Number Publication Date
CA3174980A1 true CA3174980A1 (en) 2021-10-14

Family

ID=70285536

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3174980A Pending CA3174980A1 (en) 2020-04-09 2021-04-08 New anti-malarial agents

Country Status (7)

Country Link
US (1) US12509439B2 (https=)
EP (2) EP3892332A1 (https=)
JP (2) JP2023520816A (https=)
CN (1) CN115380027B (https=)
BR (1) BR112022019710A2 (https=)
CA (1) CA3174980A1 (https=)
WO (1) WO2021204952A1 (https=)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2748147T (lt) * 2011-08-25 2017-10-25 St. Jude Children`S Research Hospital 2-alkil-1-okso-n-fenil-3-heteroaril-1,2,3,4-tetrahidroizochinolin-4-karboksamidai, skirti antimaliarinei terapijai
GB201206280D0 (en) * 2012-04-10 2012-05-23 Univ Dundee Anti-malarial agents
CN105294561B (zh) * 2015-11-27 2018-03-30 中国药科大学 一种异喹啉及其制备方法和应用

Also Published As

Publication number Publication date
EP3892332A1 (en) 2021-10-13
EP4132918A1 (en) 2023-02-15
JP2023520816A (ja) 2023-05-19
BR112022019710A2 (pt) 2022-11-16
CN115380027A (zh) 2022-11-22
US20230174503A1 (en) 2023-06-08
JP2026021396A (ja) 2026-02-10
WO2021204952A1 (en) 2021-10-14
CN115380027B (zh) 2024-10-18
US12509439B2 (en) 2025-12-30

Similar Documents

Publication Publication Date Title
ES2528796T3 (es) Benzo[c]fenantridinas pseudobásicas con eficacia, estabilidad y seguridad mejoradas
JP7352294B2 (ja) ムスカリン性アセチルコリン受容体ｍ４のアンタゴニスト
WO2007032466A1 (ja) 複素環化合物、その製造方法並びに用途
EP2814820B1 (en) Anti-malarial agents
ES3057371T3 (en) Antagonists of the muscarinic acetylcholine receptor m4
US12202835B2 (en) Substituted aromatic ring-linked dioxinoquinazolines and dioxinoquinolines as kinase inhibitors
KR20090122278A (ko) 신규한 벤질（헤테로사이클릭메틸）아민 구조를 갖는 피리미딘 화합물 및 이것을 함유하는 의약
WO2008069242A1 (ja) 新規２環性複素環化合物
US20240010640A1 (en) Antagonists of the muscarinic acetylcholine receptor m4
CA3174980A1 (en) New anti-malarial agents
US11903936B2 (en) Anti-malarial agents
RS55998B1 (sr) Novi anti-malarijski agensi
JP2019530712A (ja) 新規抗マラリア薬
WO2021200934A1 (ja) 抗マラリア薬
CN107304180B (zh) 苯甲酰胺类衍生物、其制备方法及其在医药上的用途
JP2026509195A (ja) 代謝型グルタミン酸受容体２のネガティブアロステリックモジュレーター
KR20240021796A (ko) 약제학적 화합물
WO2026080781A1 (en) 1-heteroarylazetidine-3-heteroarylmethylcarboxamide 5-ht2b antagonists
WO2022250104A1 (ja) 抗マラリア活性を有するキノロン誘導体
WO2022037601A1 (zh) 作为ep4受体拮抗剂的吡唑酰胺衍生物及其在制备治疗癌症和炎症药物中的用途
HK1202859B (en) Anti -malarial agents

Legal Events

Date Code Title Description
D11 Substantive examination requested

Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D11-D117 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST FOR EXAMINATION RECEIVED

Effective date: 20250212

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P11-P101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - VOLUNTARY AMENDMENT

Effective date: 20250212

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20250213

D00 Search and/or examination requested or commenced

Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D00-D118 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST FOR EXAMINATION REQUIREMENTS DETERMINED COMPLIANT

Effective date: 20250224

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT

Effective date: 20250224

P13 Application amended

Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED

Effective date: 20250224

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 4TH ANNIV.) - STANDARD

Year of fee payment: 4

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250331

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250331

D11 Substantive examination requested

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D11-D155 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ALL REQUIREMENTS FOR EXAMINATION DETERMINED COMPLIANT

Effective date: 20250429

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20250506

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20260219

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 5TH ANNIV.) - STANDARD

Year of fee payment: 5

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20260331

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20260331