CN115380027B - 新的抗疟疾剂 - Google Patents

新的抗疟疾剂 Download PDF

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Publication number
CN115380027B
CN115380027B CN202180027409.0A CN202180027409A CN115380027B CN 115380027 B CN115380027 B CN 115380027B CN 202180027409 A CN202180027409 A CN 202180027409A CN 115380027 B CN115380027 B CN 115380027B
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CN
China
Prior art keywords
trifluoroethyl
oxo
tetrahydroisoquinoline
iii
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202180027409.0A
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English (en)
Chinese (zh)
Other versions
CN115380027A (zh
Inventor
R·K·盖
J·T·哈米尔
D·弗洛伊德
J·博劳斯
S·布兰德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MMV Medicines for Malaria Venture
University of Kentucky Research Foundation
Original Assignee
MMV Medicines for Malaria Venture
University of Kentucky Research Foundation
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Publication date
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Publication of CN115380027A publication Critical patent/CN115380027A/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202180027409.0A 2020-04-09 2021-04-08 新的抗疟疾剂 Active CN115380027B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063007385P 2020-04-09 2020-04-09
US63/007,385 2020-04-09
EP20169099.7 2020-04-09
EP20169099.7A EP3892332A1 (en) 2020-04-09 2020-04-09 New anti-malarial agents
PCT/EP2021/059196 WO2021204952A1 (en) 2020-04-09 2021-04-08 New anti-malarial agents

Publications (2)

Publication Number Publication Date
CN115380027A CN115380027A (zh) 2022-11-22
CN115380027B true CN115380027B (zh) 2024-10-18

Family

ID=70285536

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180027409.0A Active CN115380027B (zh) 2020-04-09 2021-04-08 新的抗疟疾剂

Country Status (7)

Country Link
US (1) US12509439B2 (https=)
EP (2) EP3892332A1 (https=)
JP (2) JP2023520816A (https=)
CN (1) CN115380027B (https=)
BR (1) BR112022019710A2 (https=)
CA (1) CA3174980A1 (https=)
WO (1) WO2021204952A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104302624A (zh) * 2012-04-10 2015-01-21 邓迪大学 抗疟疾剂
CN105294561A (zh) * 2015-11-27 2016-02-03 中国药科大学 一种异喹啉及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2748147T (lt) * 2011-08-25 2017-10-25 St. Jude Children`S Research Hospital 2-alkil-1-okso-n-fenil-3-heteroaril-1,2,3,4-tetrahidroizochinolin-4-karboksamidai, skirti antimaliarinei terapijai

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104302624A (zh) * 2012-04-10 2015-01-21 邓迪大学 抗疟疾剂
CN105294561A (zh) * 2015-11-27 2016-02-03 中国药科大学 一种异喹啉及其制备方法和应用

Also Published As

Publication number Publication date
CA3174980A1 (en) 2021-10-14
EP3892332A1 (en) 2021-10-13
EP4132918A1 (en) 2023-02-15
JP2023520816A (ja) 2023-05-19
BR112022019710A2 (pt) 2022-11-16
CN115380027A (zh) 2022-11-22
US20230174503A1 (en) 2023-06-08
JP2026021396A (ja) 2026-02-10
WO2021204952A1 (en) 2021-10-14
US12509439B2 (en) 2025-12-30

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