JP2023520816A - 新規の抗マラリア薬 - Google Patents

新規の抗マラリア薬 Download PDF

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Publication number
JP2023520816A
JP2023520816A JP2022562063A JP2022562063A JP2023520816A JP 2023520816 A JP2023520816 A JP 2023520816A JP 2022562063 A JP2022562063 A JP 2022562063A JP 2022562063 A JP2022562063 A JP 2022562063A JP 2023520816 A JP2023520816 A JP 2023520816A
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JP
Japan
Prior art keywords
trifluoroethyl
oxo
tetrahydroisoquinoline
iii
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022562063A
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English (en)
Japanese (ja)
Other versions
JP2023520816A5 (https=
Inventor
ロドニー・キプリン・ガイ
ジャレッド・ティー・ハミル
デイヴィッド・フロイド
ジェレミー・バロウズ
スティーヴン・ブランド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kentucky Research Foundation
Original Assignee
University of Kentucky Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Kentucky Research Foundation filed Critical University of Kentucky Research Foundation
Publication of JP2023520816A publication Critical patent/JP2023520816A/ja
Publication of JP2023520816A5 publication Critical patent/JP2023520816A5/ja
Priority to JP2025179885A priority Critical patent/JP2026021396A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2022562063A 2020-04-09 2021-04-08 新規の抗マラリア薬 Pending JP2023520816A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025179885A JP2026021396A (ja) 2020-04-09 2025-10-24 新規の抗マラリア薬

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063007385P 2020-04-09 2020-04-09
US63/007,385 2020-04-09
EP20169099.7 2020-04-09
EP20169099.7A EP3892332A1 (en) 2020-04-09 2020-04-09 New anti-malarial agents
PCT/EP2021/059196 WO2021204952A1 (en) 2020-04-09 2021-04-08 New anti-malarial agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025179885A Division JP2026021396A (ja) 2020-04-09 2025-10-24 新規の抗マラリア薬

Publications (2)

Publication Number Publication Date
JP2023520816A true JP2023520816A (ja) 2023-05-19
JP2023520816A5 JP2023520816A5 (https=) 2024-04-19

Family

ID=70285536

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022562063A Pending JP2023520816A (ja) 2020-04-09 2021-04-08 新規の抗マラリア薬
JP2025179885A Pending JP2026021396A (ja) 2020-04-09 2025-10-24 新規の抗マラリア薬

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025179885A Pending JP2026021396A (ja) 2020-04-09 2025-10-24 新規の抗マラリア薬

Country Status (7)

Country Link
US (1) US12509439B2 (https=)
EP (2) EP3892332A1 (https=)
JP (2) JP2023520816A (https=)
CN (1) CN115380027B (https=)
BR (1) BR112022019710A2 (https=)
CA (1) CA3174980A1 (https=)
WO (1) WO2021204952A1 (https=)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014524464A (ja) * 2011-08-25 2014-09-22 セント ジュード チルドレンズ リサーチ ホスピタル 抗マラリア療法のための置換２−アルキル−１−オキソ−ｎ−フェニル−３−ヘテロアリール−１，２，３，４−テトラヒドロイソキノリン−４−カルボキサミド

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201206280D0 (en) * 2012-04-10 2012-05-23 Univ Dundee Anti-malarial agents
CN105294561B (zh) * 2015-11-27 2018-03-30 中国药科大学 一种异喹啉及其制备方法和应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014524464A (ja) * 2011-08-25 2014-09-22 セント ジュード チルドレンズ リサーチ ホスピタル 抗マラリア療法のための置換２−アルキル−１−オキソ−ｎ−フェニル−３−ヘテロアリール−１，２，３，４−テトラヒドロイソキノリン−４−カルボキサミド

Also Published As

Publication number Publication date
CA3174980A1 (en) 2021-10-14
EP3892332A1 (en) 2021-10-13
EP4132918A1 (en) 2023-02-15
BR112022019710A2 (pt) 2022-11-16
CN115380027A (zh) 2022-11-22
US20230174503A1 (en) 2023-06-08
JP2026021396A (ja) 2026-02-10
WO2021204952A1 (en) 2021-10-14
CN115380027B (zh) 2024-10-18
US12509439B2 (en) 2025-12-30

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