CA3174980A1 - Nouveaux agents antipaludiques - Google Patents

Nouveaux agents antipaludiques

Info

Publication number
CA3174980A1
CA3174980A1 CA3174980A CA3174980A CA3174980A1 CA 3174980 A1 CA3174980 A1 CA 3174980A1 CA 3174980 A CA3174980 A CA 3174980A CA 3174980 A CA3174980 A CA 3174980A CA 3174980 A1 CA3174980 A1 CA 3174980A1
Authority
CA
Canada
Prior art keywords
oxo
trifluoroethyl
iii
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3174980A
Other languages
English (en)
Inventor
Rodney Kiplin Guy
Jared T. Hammill
David Floyd
Jeremy Burrows
Stephen Brand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MMV Medicines for Malaria Venture
University of Kentucky Research Foundation
Original Assignee
MMV Medicines for Malaria Venture
University of Kentucky Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MMV Medicines for Malaria Venture, University of Kentucky Research Foundation filed Critical MMV Medicines for Malaria Venture
Publication of CA3174980A1 publication Critical patent/CA3174980A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne de nouveaux dérivés dans la fabrication d'un médicament pour la prévention ou le traitement du paludisme. En particulier, la présente invention concerne des dérivés de dihydroisoquinoléine utiles pour la préparation d'une formulation pharmaceutique pour l'inhibition de la prolifération des parasites du paludisme.
CA3174980A 2020-04-09 2021-04-08 Nouveaux agents antipaludiques Pending CA3174980A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063007385P 2020-04-09 2020-04-09
EP20169099.7 2020-04-09
US63/007,385 2020-04-09
EP20169099.7A EP3892332A1 (fr) 2020-04-09 2020-04-09 Nouveaux agents anti-paludiques
PCT/EP2021/059196 WO2021204952A1 (fr) 2020-04-09 2021-04-08 Nouveaux agents antipaludiques

Publications (1)

Publication Number Publication Date
CA3174980A1 true CA3174980A1 (fr) 2021-10-14

Family

ID=70285536

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3174980A Pending CA3174980A1 (fr) 2020-04-09 2021-04-08 Nouveaux agents antipaludiques

Country Status (7)

Country Link
US (1) US20230174503A1 (fr)
EP (2) EP3892332A1 (fr)
JP (1) JP2023520816A (fr)
CN (1) CN115380027A (fr)
BR (1) BR112022019710A2 (fr)
CA (1) CA3174980A1 (fr)
WO (1) WO2021204952A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014004437B1 (pt) 2011-08-25 2021-12-14 St. Jude Children's Research Hospital Composto, uso de um composto, composição farmacêutica, formulação farmacêutica, processo para preparação de um composto, e intermediário
GB201206280D0 (en) * 2012-04-10 2012-05-23 Univ Dundee Anti-malarial agents
CN105294561B (zh) * 2015-11-27 2018-03-30 中国药科大学 一种异喹啉及其制备方法和应用

Also Published As

Publication number Publication date
WO2021204952A1 (fr) 2021-10-14
CN115380027A (zh) 2022-11-22
BR112022019710A2 (pt) 2022-11-16
JP2023520816A (ja) 2023-05-19
US20230174503A1 (en) 2023-06-08
EP3892332A1 (fr) 2021-10-13
EP4132918A1 (fr) 2023-02-15

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