CA3168499C - Method and system for in-vivo, and non-invasive measurement of metabolite levels - Google Patents

Method and system for in-vivo, and non-invasive measurement of metabolite levels

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Publication number
CA3168499C
CA3168499C CA3168499A CA3168499A CA3168499C CA 3168499 C CA3168499 C CA 3168499C CA 3168499 A CA3168499 A CA 3168499A CA 3168499 A CA3168499 A CA 3168499A CA 3168499 C CA3168499 C CA 3168499C
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Prior art keywords
magnetic field
current carrying
bore
field
magnet
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CA3168499A
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English (en)
French (fr)
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CA3168499A1 (en
Inventor
David O'Brien
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10250929 Canada Inc
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    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4616—NMR spectroscopy using specific RF pulses or specific modulation schemes, e.g. stochastic excitation, adiabatic RF pulses, composite pulses, binomial pulses, Shinnar-le-Roux pulses, spectrally selective pulses not being used for spatial selection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
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    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
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    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
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    • A61B5/7235—Details of waveform analysis
    • A61B5/725—Details of waveform analysis using specific filters therefor, e.g. Kalman or adaptive filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/64—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving ketones
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    • G01R33/302—Miniaturized sample handling arrangements for sampling small quantities, e.g. flow-through microfluidic NMR chips
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    • G01R33/36—Electrical details, e.g. matching or coupling of the coil to the receiver
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
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    • G01R33/46—NMR spectroscopy
    • G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
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    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G01R33/56308—Characterization of motion or flow; Dynamic imaging
    • G01R33/56316—Characterization of motion or flow; Dynamic imaging involving phase contrast techniques
    • A—HUMAN NECESSITIES
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    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
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    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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    • A61B5/70—Means for positioning the patient in relation to the detecting, measuring or recording means
    • A61B5/702—Posture restraints
    • A—HUMAN NECESSITIES
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    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
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    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
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    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
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    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
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    • G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/387—Compensation of inhomogeneities
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    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
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    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5607—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by reducing the NMR signal of a particular spin species, e.g. of a chemical species for fat suppression, or of a moving spin species for black-blood imaging
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/032—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
    • H01F1/04—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys
    • H01F1/047—Alloys characterised by their composition
    • H01F1/053—Alloys characterised by their composition containing rare earth metals
    • H01F1/055—Alloys characterised by their composition containing rare earth metals and magnetic transition metals, e.g. SmCo5
    • H01F1/057—Alloys characterised by their composition containing rare earth metals and magnetic transition metals, e.g. SmCo5 and IIIa elements, e.g. Nd2Fe14B
    • H—ELECTRICITY
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    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
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    • H01F7/02—Permanent magnets [PM]
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    • H01F7/021—Construction of PM

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Signal Processing (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Optics & Photonics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Dispersion Chemistry (AREA)
CA3168499A 2018-09-14 2019-09-13 Method and system for in-vivo, and non-invasive measurement of metabolite levels Active CA3168499C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3168499A CA3168499C (en) 2018-09-14 2019-09-13 Method and system for in-vivo, and non-invasive measurement of metabolite levels

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862731576P 2018-09-14 2018-09-14
US62/731,576 2018-09-14
CA3112592A CA3112592C (en) 2018-09-14 2019-09-13 Method and system for in-vivo, and non-invasive measurement of metabolite levels
CA3168499A CA3168499C (en) 2018-09-14 2019-09-13 Method and system for in-vivo, and non-invasive measurement of metabolite levels

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3112592A Division CA3112592C (en) 2018-09-14 2019-09-13 Method and system for in-vivo, and non-invasive measurement of metabolite levels

Publications (2)

Publication Number Publication Date
CA3168499A1 CA3168499A1 (en) 2020-03-19
CA3168499C true CA3168499C (en) 2026-01-27

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CA3168499A Active CA3168499C (en) 2018-09-14 2019-09-13 Method and system for in-vivo, and non-invasive measurement of metabolite levels
CA3112592A Active CA3112592C (en) 2018-09-14 2019-09-13 Method and system for in-vivo, and non-invasive measurement of metabolite levels
CA3168472A Active CA3168472C (en) 2018-09-14 2019-09-13 Method and system for in-vivo, and non-invasive measurement of metabolite levels

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CA3168472A Active CA3168472C (en) 2018-09-14 2019-09-13 Method and system for in-vivo, and non-invasive measurement of metabolite levels

Country Status (7)

Country Link
US (3) US11561271B2 (cg-RX-API-DMAC7.html)
EP (1) EP3850386A4 (cg-RX-API-DMAC7.html)
JP (1) JP7621937B2 (cg-RX-API-DMAC7.html)
KR (1) KR102812888B1 (cg-RX-API-DMAC7.html)
CN (1) CN112955767B (cg-RX-API-DMAC7.html)
CA (3) CA3168499C (cg-RX-API-DMAC7.html)
WO (1) WO2020051716A1 (cg-RX-API-DMAC7.html)

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US11501931B2 (en) * 2018-07-25 2022-11-15 Hubbell Incorporated Circuit interrupting device having printed circuit board coils
CN112955767B (zh) 2018-09-14 2024-12-10 10250929加拿大有限公司 体内和非侵入性测量代谢物水平的方法和系统
US20200187793A1 (en) * 2018-12-18 2020-06-18 Movano Inc. Systems for radio wave based health monitoring that utilize data derived from amplitude and/or phase data
US11971464B1 (en) * 2019-12-20 2024-04-30 The United States Of America, Represented By The Secretary Of The Navy Magnon excitation and detection systems, apparatus, and methods
JP7412759B2 (ja) * 2020-04-16 2024-01-15 松谷化学工業株式会社 水溶性食物繊維のエネルギー量の簡便な測定方法
WO2022051717A1 (en) * 2020-09-04 2022-03-10 Musc Foundation For Research Development Methods, systems, and computer readable media for utilizing spectral circles for magnetic resonance spectroscopy analysis
CN112244812B (zh) * 2020-10-19 2023-08-22 上海联影医疗科技股份有限公司 磁共振成像方法、磁共振成像系统和电子装置
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CN115831570B (zh) * 2021-09-16 2026-03-06 中国科学院苏州生物医学工程技术研究所 Halbach构型磁体的匀场方法
CN115327459B (zh) * 2022-08-18 2025-10-17 深圳市联影高端医疗装备创新研究院 一种并行发射局部激发脉冲生成方法、装置和存储介质
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WO2024130115A1 (en) * 2022-12-15 2024-06-20 The General Hospital Corporation Systems and methods for performing x-nuclear magnetic resonance spectroscopy or magnetic resonance imaging on diverse system configurations
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