CN112955767B - 体内和非侵入性测量代谢物水平的方法和系统 - Google Patents

体内和非侵入性测量代谢物水平的方法和系统 Download PDF

Info

Publication number
CN112955767B
CN112955767B CN201980070629.4A CN201980070629A CN112955767B CN 112955767 B CN112955767 B CN 112955767B CN 201980070629 A CN201980070629 A CN 201980070629A CN 112955767 B CN112955767 B CN 112955767B
Authority
CN
China
Prior art keywords
sample
glucose
magnetic field
frequency
permanent magnet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201980070629.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN112955767A (zh
Inventor
大卫·奥布莱恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
10250929 Canada Ltd
Original Assignee
10250929 Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 10250929 Canada Ltd filed Critical 10250929 Canada Ltd
Publication of CN112955767A publication Critical patent/CN112955767A/zh
Application granted granted Critical
Publication of CN112955767B publication Critical patent/CN112955767B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46NMR spectroscopy
    • G01R33/4616NMR spectroscopy using specific RF pulses or specific modulation schemes, e.g. stochastic excitation, adiabatic RF pulses, composite pulses, binomial pulses, Shinnar-le-Roux pulses, spectrally selective pulses not being used for spatial selection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14539Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/725Details of waveform analysis using specific filters therefor, e.g. Kalman or adaptive filters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/64Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving ketones
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/30Sample handling arrangements, e.g. sample cells, spinning mechanisms
    • G01R33/302Miniaturized sample handling arrangements for sampling small quantities, e.g. flow-through microfluidic NMR chips
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/34046Volume type coils, e.g. bird-cage coils; Quadrature bird-cage coils; Circularly polarised coils
    • G01R33/34053Solenoid coils; Toroidal coils
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/36Electrical details, e.g. matching or coupling of the coil to the receiver
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/36Electrical details, e.g. matching or coupling of the coil to the receiver
    • G01R33/3678Electrical details, e.g. matching or coupling of the coil to the receiver involving quadrature drive or detection, e.g. a circularly polarized RF magnetic field
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46NMR spectroscopy
    • G01R33/4625Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46NMR spectroscopy
    • G01R33/465NMR spectroscopy applied to biological material, e.g. in vitro testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/54Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G01R33/56308Characterization of motion or flow; Dynamic imaging
    • G01R33/56316Characterization of motion or flow; Dynamic imaging involving phase contrast techniques
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04Constructional details of apparatus
    • A61B2560/0431Portable apparatus, e.g. comprising a handle or case
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/70Means for positioning the patient in relation to the detecting, measuring or recording means
    • A61B5/702Posture restraints
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/7253Details of waveform analysis characterised by using transforms
    • A61B5/7257Details of waveform analysis characterised by using transforms using Fourier transforms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271Specific aspects of physiological measurement analysis
    • A61B5/7278Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/48Reserve carbohydrates, e.g. glycogen
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/38Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/383Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using permanent magnets
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/38Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/387Compensation of inhomogeneities
    • G01R33/3875Compensation of inhomogeneities using correction coil assemblies, e.g. active shimming
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/54Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5607Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by reducing the NMR signal of a particular spin species, e.g. of a chemical species for fat suppression, or of a moving spin species for black-blood imaging
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01FMAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/032Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
    • H01F1/04Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys
    • H01F1/047Alloys characterised by their composition
    • H01F1/053Alloys characterised by their composition containing rare earth metals
    • H01F1/055Alloys characterised by their composition containing rare earth metals and magnetic transition metals, e.g. SmCo5
    • H01F1/057Alloys characterised by their composition containing rare earth metals and magnetic transition metals, e.g. SmCo5 and IIIa elements, e.g. Nd2Fe14B
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01FMAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F7/00Magnets
    • H01F7/02Permanent magnets [PM]
    • H01F7/0205Magnetic circuits with PM in general
    • H01F7/021Construction of PM

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Signal Processing (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Optics & Photonics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Dispersion Chemistry (AREA)
CN201980070629.4A 2018-09-14 2019-09-13 体内和非侵入性测量代谢物水平的方法和系统 Active CN112955767B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862731576P 2018-09-14 2018-09-14
US62/731,576 2018-09-14
PCT/CA2019/051305 WO2020051716A1 (en) 2018-09-14 2019-09-13 Method and system for in-vivo, and non-invasive measurement of metabolite levels

Publications (2)

Publication Number Publication Date
CN112955767A CN112955767A (zh) 2021-06-11
CN112955767B true CN112955767B (zh) 2024-12-10

Family

ID=69777371

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980070629.4A Active CN112955767B (zh) 2018-09-14 2019-09-13 体内和非侵入性测量代谢物水平的方法和系统

Country Status (7)

Country Link
US (3) US11561271B2 (cg-RX-API-DMAC7.html)
EP (1) EP3850386A4 (cg-RX-API-DMAC7.html)
JP (1) JP7621937B2 (cg-RX-API-DMAC7.html)
KR (1) KR102812888B1 (cg-RX-API-DMAC7.html)
CN (1) CN112955767B (cg-RX-API-DMAC7.html)
CA (3) CA3168499C (cg-RX-API-DMAC7.html)
WO (1) WO2020051716A1 (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7291712B2 (ja) 2017-11-12 2023-06-15 シーネクス メディカル インコーポレイテッド 装着型の血液検体測定装置及び血液検体濃度を測定する方法
US11501931B2 (en) * 2018-07-25 2022-11-15 Hubbell Incorporated Circuit interrupting device having printed circuit board coils
CN112955767B (zh) 2018-09-14 2024-12-10 10250929加拿大有限公司 体内和非侵入性测量代谢物水平的方法和系统
US20200187793A1 (en) * 2018-12-18 2020-06-18 Movano Inc. Systems for radio wave based health monitoring that utilize data derived from amplitude and/or phase data
US11971464B1 (en) * 2019-12-20 2024-04-30 The United States Of America, Represented By The Secretary Of The Navy Magnon excitation and detection systems, apparatus, and methods
JP7412759B2 (ja) * 2020-04-16 2024-01-15 松谷化学工業株式会社 水溶性食物繊維のエネルギー量の簡便な測定方法
WO2022051717A1 (en) * 2020-09-04 2022-03-10 Musc Foundation For Research Development Methods, systems, and computer readable media for utilizing spectral circles for magnetic resonance spectroscopy analysis
CN112244812B (zh) * 2020-10-19 2023-08-22 上海联影医疗科技股份有限公司 磁共振成像方法、磁共振成像系统和电子装置
EP4099567B1 (en) * 2021-05-31 2024-10-30 Schneider Electric Industries SAS Monitoring of magnetic sensing elements of a switching device
US20240350027A1 (en) * 2021-08-17 2024-10-24 ViBo Health Inc. Methods and Apparatus for Benchtop Metabolite Profiling in Situ
CN115831570B (zh) * 2021-09-16 2026-03-06 中国科学院苏州生物医学工程技术研究所 Halbach构型磁体的匀场方法
CN115327459B (zh) * 2022-08-18 2025-10-17 深圳市联影高端医疗装备创新研究院 一种并行发射局部激发脉冲生成方法、装置和存储介质
US12306276B2 (en) 2022-11-08 2025-05-20 Synex Medical Inc. System and method for nuclear magnetic resonance calibration
WO2024130115A1 (en) * 2022-12-15 2024-06-20 The General Hospital Corporation Systems and methods for performing x-nuclear magnetic resonance spectroscopy or magnetic resonance imaging on diverse system configurations
CN121079606A (zh) * 2023-03-13 2025-12-05 量子谷投资基金有限合伙公司 磁共振系统的数字操作
WO2024254142A1 (en) * 2023-06-05 2024-12-12 James Rahner Portable nmr apparatus and systems and methods for analyzing nmr data obtained therefrom
CN116500207B (zh) * 2023-06-27 2023-08-29 佳木斯大学 麻醉气体的浓度测量方法及系统
CN121793899A (zh) 2023-08-08 2026-04-03 辛克斯医疗公司 用于血液分析物水平的核磁共振测量的系统和方法
WO2025199535A1 (en) * 2024-03-22 2025-09-25 ViiT Health, Inc. Systems and methods for non-invasive identification of biomarkers
WO2026024763A1 (en) 2024-07-22 2026-01-29 Synex Medical Inc. Magnet system for nuclear magnetic resonance

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002017704A (ja) * 2000-06-30 2002-01-22 Toshiba Corp 磁気共鳴診断装置
CN101356447A (zh) * 2005-07-21 2009-01-28 约翰斯霍普金斯大学 组织糖原的非侵入式mri测定

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3488561A (en) 1965-03-23 1970-01-06 Varian Associates Apparatus for controlling magnetic fields
US4875486A (en) * 1986-09-04 1989-10-24 Advanced Techtronics, Inc. Instrument and method for non-invasive in vivo testing for body fluid constituents
US5072732A (en) * 1986-09-04 1991-12-17 Advanced Techtronics, Inc. NMR instrument for testing for fluid constituents
US5320103A (en) 1987-10-07 1994-06-14 Advanced Techtronics, Inc. Permanent magnet arrangement
DE3914351A1 (de) 1989-04-29 1990-10-31 Bruker Medizintech Verfahren zur aufnahme von spinresonanzspektren
JPH06114026A (ja) * 1992-10-06 1994-04-26 Yokogawa Medical Syst Ltd 化学シフトイメージング方法
US5433196A (en) 1993-06-02 1995-07-18 The Board Of Trustees Of The University Of Illinois Oxygen-17 NMR spectroscopy and imaging in the human
US5685300A (en) * 1994-04-01 1997-11-11 Kuenstner; J. Todd Noninvasive and in-vitro measurement of glucose and cholesterol by nuclear magnetic resonance spectroscopy
US5635889A (en) 1995-09-21 1997-06-03 Permag Corporation Dipole permanent magnet structure
JP3023310B2 (ja) 1996-05-31 2000-03-21 松下電器産業株式会社 光学的情報記録媒体の記録再生方法および記録再生装置
US5886609A (en) 1997-10-22 1999-03-23 Dexter Magnetic Technologies, Inc. Single dipole permanent magnet structure with linear gradient magnetic field intensity
US6163154A (en) 1997-12-23 2000-12-19 Magnetic Diagnostics, Inc. Small scale NMR spectroscopic apparatus and method
JP4462781B2 (ja) 2001-04-12 2010-05-12 株式会社日立メディコ 磁気共鳴イメージング装置
KR100600706B1 (ko) * 2004-07-09 2006-07-14 삼성전자주식회사 자기공명흡수법을 이용한 무혈혈당 측정장치 및 측정 방법
US7449886B2 (en) 2004-11-18 2008-11-11 General Electric Company MR receiver assembly having readout cables capable of multiple channel transmissions
US7161511B2 (en) 2005-06-03 2007-01-09 General Electric Company Linearization system and method
JP2009513218A (ja) 2005-10-28 2009-04-02 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 単一rf増幅器を用いた複数核の同時mr励起
US8368402B2 (en) 2006-11-08 2013-02-05 T2 Biosystems, Inc. NMR systems for in vivo detection of analytes
US8773126B2 (en) 2007-09-07 2014-07-08 Canon Kabushiki Kaisha Nuclear magnetic resonance measuring method using an isotope-labeled compound
US20090264789A1 (en) 2007-09-26 2009-10-22 Medtronic, Inc. Therapy program selection
WO2009042170A1 (en) * 2007-09-26 2009-04-02 Medtronic, Inc. Therapy program selection
US8164336B1 (en) 2007-11-10 2012-04-24 Murphree Jr Dennis Haaga Transmission line probe for NMR
FR2949604B1 (fr) 2009-08-28 2012-03-02 Commissariat Energie Atomique Structure aimantee axisymetrique induisant en son centre un champ homogene d'orientation predeterminee
US8515533B2 (en) * 2009-09-30 2013-08-20 Broadcom Corporation Bio-medical unit system for physical therapy
US20110144573A1 (en) * 2009-09-30 2011-06-16 Broadcom Corporation Bio-medical unit system for medication control
US8217651B2 (en) * 2009-10-30 2012-07-10 General Electric Company Amplified radiation damping for MR imaging and spectroscopy
BR112012013588B1 (pt) 2009-12-02 2021-01-26 Nanalysis Corp. método para homogeneizar um campo magnético, detector para detectar a ressonância magnética e painel para homogeneizar um campo magnético
DE102011081039A1 (de) 2011-08-16 2013-02-21 Siemens Aktiengesellschaft Lokalspulenanordnung mit integriertem Shimleiter
EP2812716A4 (en) 2012-02-08 2015-07-29 Anatech Advanced Nmr Algorithms Technologies Ltd DEVICE AND METHOD FOR THE NONINVASIVE MEASUREMENT OF BLOOD PARAMETERS
US9606106B2 (en) 2012-02-10 2017-03-28 Children's Medical Center Corporation NMR-based metabolite screening platform
US9361429B2 (en) * 2012-06-08 2016-06-07 Liposcience, Inc. Multi-parameter diabetes risk evaluations
FR2999723B1 (fr) 2012-12-14 2015-03-06 Commissariat Energie Atomique Dispositif de generation d'un champ magnetique orientable et localement homogene.
US9730628B2 (en) * 2013-03-12 2017-08-15 The Cleveland Clinic Foundation System and method for identifying a focal area of abnormal network interactions in the brain
FR3003958B1 (fr) 2013-03-26 2017-02-24 Commissariat Energie Atomique Sonde et appareil pour resonance magnetique nucleaire, bobine a radiofrequence utilisable dans une telle sonde et procede de generation d'un champ magnetique a radiofrequence utilisant une telle bobine.
US20160011290A1 (en) * 2013-05-21 2016-01-14 Victor Iannello Non-Invasive, In-Vivo Measurement of Blood Constituents Using a Portable Nuclear Magnetic Resonance Device
US10203389B2 (en) * 2014-04-23 2019-02-12 University of Pittsburgh—of the Commonwealth System of Higher Education Method and system for monitoring glucose transport and metabolism by spin-lock magnetic resonance
KR20170048560A (ko) * 2014-09-05 2017-05-08 하이퍼파인 리서치, 인크. 낮은 필드 자기 공명 이미징 방법들 및 장치
US10813564B2 (en) 2014-11-11 2020-10-27 Hyperfine Research, Inc. Low field magnetic resonance methods and apparatus
TR201804106T1 (tr) 2016-01-28 2018-04-24 Aselsan Elektronik Sanayi Ve Ticaret As Ssb modülasyon i̇le paralel manyeti̇k rezonans görüntüleme i̇çi̇n tamamen sayisal çok kanalli rf veri̇ci̇
DE102016203588A1 (de) 2016-03-04 2017-09-07 Bruker Biospin Gmbh Streufeldarme Permanentmagnetanordnung für MR-Apparaturen
EP3236277B1 (en) * 2016-04-18 2021-12-01 Centre Hospitalier Universitaire Vaudois (CHUV) Differentiated tissue excitation by mri using binomial off-resonance 1-1 rf pulses
US11439313B2 (en) * 2016-05-16 2022-09-13 Bitome, Inc. Small form factor digitally tunable NMR in vivo biometric monitor for metabolic state of a sample
US10955504B2 (en) * 2016-11-22 2021-03-23 Hyperfine Research, Inc. Systems and methods for automated detection in magnetic resonance images
US10627464B2 (en) 2016-11-22 2020-04-21 Hyperfine Research, Inc. Low-field magnetic resonance imaging methods and apparatus
JP7291712B2 (ja) 2017-11-12 2023-06-15 シーネクス メディカル インコーポレイテッド 装着型の血液検体測定装置及び血液検体濃度を測定する方法
CN112955767B (zh) * 2018-09-14 2024-12-10 10250929加拿大有限公司 体内和非侵入性测量代谢物水平的方法和系统
US11143727B2 (en) * 2019-05-06 2021-10-12 Massachusetts Institute Of Technology Miniature stochastic nuclear magnetic resonance

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002017704A (ja) * 2000-06-30 2002-01-22 Toshiba Corp 磁気共鳴診断装置
CN101356447A (zh) * 2005-07-21 2009-01-28 约翰斯霍普金斯大学 组织糖原的非侵入式mri测定

Also Published As

Publication number Publication date
CA3168499C (en) 2026-01-27
CA3168472C (en) 2026-03-10
US20210199736A1 (en) 2021-07-01
CA3168499A1 (en) 2020-03-19
US20210196160A1 (en) 2021-07-01
US11561271B2 (en) 2023-01-24
CA3112592A1 (en) 2020-03-19
US11237237B2 (en) 2022-02-01
CA3168472A1 (en) 2020-03-19
EP3850386A4 (en) 2022-10-12
CA3112592C (en) 2022-09-20
WO2020051716A1 (en) 2020-03-19
JP2022500656A (ja) 2022-01-04
US20210196143A1 (en) 2021-07-01
KR102812888B1 (ko) 2025-05-27
CN112955767A (zh) 2021-06-11
KR20210060534A (ko) 2021-05-26
EP3850386A1 (en) 2021-07-21
JP7621937B2 (ja) 2025-01-27
US11579225B2 (en) 2023-02-14

Similar Documents

Publication Publication Date Title
CN112955767B (zh) 体内和非侵入性测量代谢物水平的方法和系统
Gruber et al. RF coils: A practical guide for nonphysicists
Juchem et al. Magnetic field modeling with a set of individual localized coils
Hayes The development of the birdcage resonator: a historical perspective
JP3957327B2 (ja) Nmr用の直角位相だ円形バード・ケージ・コイル
Borowiak et al. A battery-driven, low-field NMR unit for thermally and hyperpolarized samples
Gilbert et al. Radiofrequency coil for routine ultra‐high‐field imaging with an unobstructed visual field
De Zanche et al. Asymmetric quadrature split birdcage coil for hyperpolarized 3He lung MRI at 1.5 T
Hayden et al. Specific absorption rates and signal‐to‐noise ratio limitations for MRI in very‐low magnetic fields
Winkler et al. Comparison of new element designs for combined RF‐shim arrays at 7 T
Petrie et al. Optimizing spherical navigator echoes for three‐dimensional rigid‐body motion detection
Frijia et al. Design, simulation, and test of surface and volume radio frequency coils for 13C magnetic resonance imaging and spectroscopy
Giovannetti et al. Radio frequency coils for hyperpolarized 13C magnetic resonance experiments with a 3T MR clinical scanner: Experience from a cardiovascular Lab
Esmaeilizadshali et al. Localized shims enable low-field simultaneous multinuclear NMR spectroscopy
Biller et al. Characterization of a PXI e based low‐field digital NMR spectrometer
Youngdee et al. Optimization of field-cycled PEDRI for in vivo imaging of free radicals
Giovannetti et al. A novel method for coil efficiency estimation: Validation with a 13C birdcage
Bolding Cheaper, Quieter, and More Accessible MRI: Compact High-Speed Switching Power Conversion and New System Architectures
Schildknecht Advances in MRI instrumentation
Gilbert et al. Integration of a radiofrequency coil and commercial field camera for ultra-high-field MRI
Rienstra Solid state nuclear magnetic resonance methodology for biomolecular structure determination
Thomson Estimation and Reduction of Temporal Magnetic Field Fluctuations in Powered Magnets using Inductive and NMR Feedback Control
Resmer A Gradient and RF System for Open Access Low Field MRI
Stoeckli et al. A High-Sensitivity Low-Cost Digital ¹H and ¹²⁹Xe NMR Spectrometer Operating in the mT Field Regime
Parra-Robles et al. Passive shimming of the fringe field of a superconducting magnet for ultra-low field hyperpolarized noble gas MRI

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant