CA3157785A1 - Polypeptides associes a hmgb1 utiles pour favoriser la regeneration tissulaire, compositions les comprenant et leurs utilisations - Google Patents
Polypeptides associes a hmgb1 utiles pour favoriser la regeneration tissulaire, compositions les comprenant et leurs utilisations Download PDFInfo
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- CA3157785A1 CA3157785A1 CA3157785A CA3157785A CA3157785A1 CA 3157785 A1 CA3157785 A1 CA 3157785A1 CA 3157785 A CA3157785 A CA 3157785A CA 3157785 A CA3157785 A CA 3157785A CA 3157785 A1 CA3157785 A1 CA 3157785A1
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- 239000011686 zinc sulphate Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
Abstract
La présente invention concerne un polypeptide représenté par la formule suivante : H2N-A-X-B-A-X-B-HOOC dans laquelle A représente des acides aminés consécutifs, dont la séquence (1) comprend une séquence identique à la séquence des acides aminés 90 à 93 de la protéine HMGB1 de type sauvage, (2) possède, au niveau de son extrémité N-terminale, entre un et six acides aminés consécutifs, par exemple, 1, 2, 3, 4, 5 ou 6 acides aminés, dont la séquence est identique à la séquence de un à six acides aminés correspondants précédant l'acide aminé 90 dans la protéine HMGB1 de type sauvage et, éventuellement, (3) possède une méthionine au niveau de l'extrémité N-terminale; X représente des acides aminés consécutifs, dont la séquence est identique à la séquence des acides aminés 94 à 162 de la protéine HMGB1 de type sauvage; et B représente des acides aminés consécutifs, dont la séquence (1) comprend une séquence identique à la séquence des acides aminés 163 à 168 de la protéine HMGB1 de type sauvage et (2) possède, au niveau de son extrémité carboxy-terminale, entre un et six acides aminés consécutifs, par exemple, 1, 2, 3, 4, 5 ou 6 acides aminés, dont la séquence est identique à la séquence des un à six acides aminés correspondants suivant l'acide aminé 168 dans la protéine HMGB1 de type sauvage; et chaque - représente une liaison peptidique entre chacun parmi A et X, X et B, B et A, A et X, et X et B.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962934299P | 2019-11-12 | 2019-11-12 | |
| US62/934,299 | 2019-11-12 | ||
| PCT/IB2020/060674 WO2021094983A1 (fr) | 2019-11-12 | 2020-11-12 | Polypeptides associés à hmgb1 utiles pour favoriser la régénération tissulaire, compositions les comprenant et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3157785A1 true CA3157785A1 (fr) | 2021-05-20 |
Family
ID=73835632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3157785A Pending CA3157785A1 (fr) | 2019-11-12 | 2020-11-12 | Polypeptides associes a hmgb1 utiles pour favoriser la regeneration tissulaire, compositions les comprenant et leurs utilisations |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP4058033A1 (fr) |
| JP (1) | JP2023512392A (fr) |
| KR (1) | KR20220137876A (fr) |
| AU (1) | AU2020385059A1 (fr) |
| CA (1) | CA3157785A1 (fr) |
| WO (1) | WO2021094983A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3219138A1 (fr) * | 2021-05-19 | 2022-11-24 | Jagdeep Nanchahal | Polypeptides associes a hmgb1 utiles pour favoriser la regeneration tissulaire, compositions les comprenant et leurs utilisations |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090069227A9 (en) | 2003-04-29 | 2009-03-12 | Capogrossi Maurizio C | Use of HMGB1 to promote stem cell migration and/or proliferation |
| US20090202500A1 (en) | 2006-10-30 | 2009-08-13 | Genomix Co., Ltd. | Pharmaceuticals That Promote Functional Regeneration of Damaged Tissues |
| RU2599448C2 (ru) * | 2009-10-28 | 2016-10-10 | Дженомикс Ко., Лтд. | Средства для стимуляции регенерации тканей путем привлечения мезенхимных стволовых клеток и/или плюрипотентных стволовых клеток костного мозга в кровь |
| EP2703487B1 (fr) * | 2011-04-26 | 2018-06-27 | Genomix Co., Ltd. | Peptide permettant d'induire la régénération d'un tissu et son utilisation |
| US10626153B2 (en) | 2012-07-26 | 2020-04-21 | Ospedale San Raffaele S.R.L. | HMGB1 variants and uses thereof |
| MX361259B (es) | 2012-10-25 | 2018-11-30 | Univ Osaka | Uso de un fragmento de peptido hmgb1 para el tratamiento del infarto al miocardio. |
-
2020
- 2020-11-12 KR KR1020227019798A patent/KR20220137876A/ko unknown
- 2020-11-12 WO PCT/IB2020/060674 patent/WO2021094983A1/fr unknown
- 2020-11-12 CA CA3157785A patent/CA3157785A1/fr active Pending
- 2020-11-12 JP JP2022528186A patent/JP2023512392A/ja active Pending
- 2020-11-12 AU AU2020385059A patent/AU2020385059A1/en active Pending
- 2020-11-12 EP EP20824631.4A patent/EP4058033A1/fr active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021094983A1 (fr) | 2021-05-20 |
| AU2020385059A1 (en) | 2022-06-02 |
| JP2023512392A (ja) | 2023-03-27 |
| KR20220137876A (ko) | 2022-10-12 |
| EP4058033A1 (fr) | 2022-09-21 |
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