CA3152003A1 - Copolymere hydrophile-hydrophobe portant un ester d'acide gras a chaine courte - Google Patents

Copolymere hydrophile-hydrophobe portant un ester d'acide gras a chaine courte Download PDF

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Publication number
CA3152003A1
CA3152003A1 CA3152003A CA3152003A CA3152003A1 CA 3152003 A1 CA3152003 A1 CA 3152003A1 CA 3152003 A CA3152003 A CA 3152003A CA 3152003 A CA3152003 A CA 3152003A CA 3152003 A1 CA3152003 A1 CA 3152003A1
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preventing
group
treating
hydrophilic
formula
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Yukio Nagasaki
Babita SHASHNI
Binh Long VONG
Ryusaku OKADA
Yuya TAJIKA
Yaroslav LEE
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University of Tsukuba NUC
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University of Tsukuba NUC
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/337—Polymers modified by chemical after-treatment with organic compounds containing other elements
    • C—CHEMISTRY; METALLURGY
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    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
    • C08F290/06—Polymers provided for in subclass C08G
    • C08F290/062—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
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    • C08F8/14—Esterification
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    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
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    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
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    • C08G65/32—Polymers modified by chemical after-treatment
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    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
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    • C08G65/32—Polymers modified by chemical after-treatment
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    • C08F2438/00—Living radical polymerisation
    • C08F2438/03—Use of a di- or tri-thiocarbonylthio compound, e.g. di- or tri-thioester, di- or tri-thiocarbamate, or a xanthate as chain transfer agent, e.g . Reversible Addition Fragmentation chain Transfer [RAFT] or Macromolecular Design via Interchange of Xanthates [MADIX]
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    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
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Abstract

Le problème décrit par la présente invention est de fournir un dérivé d'acide gras à chaîne courte capable d'assurer une fonction physiologique inhérente à un acide gras à chaîne courte. La solution selon l'invention porte sur un copolymère séquencé ou greffé contenant : un segment hydrophobe ayant une unité de répétition comprenant un acide gras à chaîne courte qui peut être hydrolysé par une estérase In vivo; et un segment hydrophile comprenant une chaîne poly(éthylène glycol). Ce copolymère est efficace dans le traitement ou le traitement thérapeutique de diverses maladies ou troubles, y compris du cancer.
CA3152003A 2019-08-05 2020-07-30 Copolymere hydrophile-hydrophobe portant un ester d'acide gras a chaine courte Pending CA3152003A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-143619 2019-08-05
JP2019143619 2019-08-05
PCT/JP2020/029239 WO2021024906A1 (fr) 2019-08-05 2020-07-30 Copolymère hydrophile-hydrophobe portant un ester d'acide gras à chaîne courte

Publications (1)

Publication Number Publication Date
CA3152003A1 true CA3152003A1 (fr) 2021-02-11

Family

ID=74503809

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3152003A Pending CA3152003A1 (fr) 2019-08-05 2020-07-30 Copolymere hydrophile-hydrophobe portant un ester d'acide gras a chaine courte

Country Status (7)

Country Link
US (1) US20220332876A1 (fr)
EP (1) EP4011444A4 (fr)
JP (1) JP7548586B2 (fr)
CN (1) CN114430756A (fr)
AU (1) AU2020324649A1 (fr)
CA (1) CA3152003A1 (fr)
WO (1) WO2021024906A1 (fr)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4212768A1 (de) * 1992-04-16 1993-10-21 Huels Chemische Werke Ag Verfahren zur Herstellung von wäßrigen Polymerdispersionen
JP3228482B2 (ja) * 1992-06-29 2001-11-12 株式会社クラレ 分散安定剤および水性分散液
WO2001037803A2 (fr) * 1999-11-15 2001-05-31 Biocure, Inc. Particules polymeres creuses sensibles
US20070122443A1 (en) * 2005-11-29 2007-05-31 Narayanan Pallassana V Amphiphilic copolymer compositions
US8980241B2 (en) 2008-05-02 2015-03-17 University Of Tsukuba Polymerized cyclic nitroxide radical compound and use thereof
WO2016052463A1 (fr) 2014-09-30 2016-04-07 国立大学法人筑波大学 Poly(éthylène glycol)-b-poly (halogénométhylstyrène) et dérivés de ce dernier, et son procédé de production
WO2018135592A1 (fr) * 2017-01-19 2018-07-26 国立大学法人筑波大学 Copolymère contenant un radical nitroxyde cyclique et du trialcoxysilyle dans une chaîne latérale, et son utilisation
JP7136807B2 (ja) * 2017-04-17 2022-09-13 ザ・ユニバーシティ・オブ・シカゴ ヒトの健康及び疾患の治療用途向けの短鎖脂肪酸の腸への送達用ポリマー材料
JP7116428B2 (ja) * 2017-06-19 2022-08-10 国立大学法人 筑波大学 感染症治療薬
JPWO2019208617A1 (ja) * 2018-04-27 2021-05-13 国立大学法人 筑波大学 ソラフェニブの経口デリバリー用組成物及びその使用

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Publication number Publication date
US20220332876A1 (en) 2022-10-20
WO2021024906A1 (fr) 2021-02-11
EP4011444A1 (fr) 2022-06-15
CN114430756A (zh) 2022-05-03
JP7548586B2 (ja) 2024-09-10
EP4011444A4 (fr) 2023-10-25
JPWO2021024906A1 (fr) 2021-02-11
AU2020324649A1 (en) 2022-03-17

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