CA3146019A1 - Anti-dll3 chimeric antigen receptors and uses thereof - Google Patents

Anti-dll3 chimeric antigen receptors and uses thereof Download PDF

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Publication number
CA3146019A1
CA3146019A1 CA3146019A CA3146019A CA3146019A1 CA 3146019 A1 CA3146019 A1 CA 3146019A1 CA 3146019 A CA3146019 A CA 3146019A CA 3146019 A CA3146019 A CA 3146019A CA 3146019 A1 CA3146019 A1 CA 3146019A1
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Canada
Prior art keywords
amino acid
seq
acid sequence
variant
cdr1
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Pending
Application number
CA3146019A
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English (en)
French (fr)
Inventor
Tao Zhao
Yuanyuan Peng
An TANG
Sujuan WANG
Shuai Yang
Wang ZHANG
Shu Wu
Ruidong HAO
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Legend Biotech Ireland Ltd
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Nanjing Legend Biotechnology Co Ltd
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Application filed by Nanjing Legend Biotechnology Co Ltd filed Critical Nanjing Legend Biotechnology Co Ltd
Publication of CA3146019A1 publication Critical patent/CA3146019A1/en
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0634—Cells from the blood or the immune system
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    • C12N5/0602—Vertebrate cells
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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CA3146019A 2019-07-17 2020-07-17 Anti-dll3 chimeric antigen receptors and uses thereof Pending CA3146019A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2019096360 2019-07-17
CNPCT/CN2019/096360 2019-07-17
CN2020090587 2020-05-15
CNPCT/CN2020/090587 2020-05-15
PCT/CN2020/102717 WO2021008610A1 (en) 2019-07-17 2020-07-17 Anti-dll3 chimeric antigen receptors and uses thereof

Publications (1)

Publication Number Publication Date
CA3146019A1 true CA3146019A1 (en) 2021-01-21

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ID=74210175

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Application Number Title Priority Date Filing Date
CA3146019A Pending CA3146019A1 (en) 2019-07-17 2020-07-17 Anti-dll3 chimeric antigen receptors and uses thereof

Country Status (9)

Country Link
US (2) US12421292B2 (https=)
EP (2) EP4527466A3 (https=)
JP (3) JP7748933B2 (https=)
KR (1) KR20220035367A (https=)
CN (4) CN114072427B (https=)
AU (1) AU2020314509A1 (https=)
CA (1) CA3146019A1 (https=)
TW (2) TW202535924A (https=)
WO (1) WO2021008610A1 (https=)

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CN115298223A (zh) 2020-03-12 2022-11-04 南京传奇生物科技有限公司 磷脂酰肌醇蛋白聚糖-2结合部分、嵌合抗原受体及其用途
EP4313081A4 (en) * 2021-04-02 2025-04-09 Nanjing Legend Biotech Co., Ltd. MANIPULATED IMMUNE CELLS AND THEIR USES
AU2022339815A1 (en) * 2021-09-02 2024-03-14 Memorial Hospital For Cancer And Allied Diseases Antigen recognizing receptors targeting dll3 and uses thereof
AU2023297866A1 (en) * 2022-06-28 2024-12-12 Resolution Therapeutics Limited Switch receptors and modified immune cells
JP2025525496A (ja) * 2022-07-08 2025-08-05 イマジナブ・インコーポレーテッド Ｄｌｌ３抗原結合構築物
WO2024044779A2 (en) * 2022-08-26 2024-02-29 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for delta-like ligand 3 (dll3)
CN115820698B (zh) * 2022-11-22 2025-01-21 浙江康佰裕生物科技有限公司 含有嵌合抗原受体和嵌合转换开关受体编码基因的融合基因及其应用
CN116004547B (zh) * 2023-03-06 2025-04-25 浙江康佰裕生物科技有限公司 一种辐照car-t细胞及其制备方法与应用
CN121152872A (zh) * 2023-05-10 2025-12-16 南京传奇生物科技有限公司 嵌合抗原受体及其使用方法
AU2024347905A1 (en) * 2023-09-26 2026-04-02 Legend Biotech Ireland Limited Dll3 binding moieties and uses thereof
WO2025201493A1 (zh) * 2024-03-29 2025-10-02 诺纳生物（苏州）有限公司 Dll3结合分子及其用途
WO2025212519A1 (en) * 2024-04-01 2025-10-09 Moonlight Bio, Inc. Dll3 binding proteins and uses thereof
WO2025240849A1 (en) * 2024-05-16 2025-11-20 The Brigham And Women's Hospital, Inc. Trem2 chimeric antigen receptors and uses thereof
WO2026008059A1 (en) * 2024-07-04 2026-01-08 Nanjing Legend Biotech Co., Ltd. Anti-dll3 constructs and uses thereof
CN119708238B (zh) * 2025-02-27 2025-07-04 昕传生物科技(北京)有限公司 靶向dll3的抗体、嵌合抗原受体及其应用

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EP3999550A1 (en) 2022-05-25
JP2026001061A (ja) 2026-01-06
CN118496374A (zh) 2024-08-16
EP4527466A3 (en) 2025-06-18
TW202116812A (zh) 2021-05-01
JP2025069305A (ja) 2025-04-30
US20260078166A1 (en) 2026-03-19
EP3999550A4 (en) 2023-09-06
US12421292B2 (en) 2025-09-23
TW202535924A (zh) 2025-09-16
CN117106099A (zh) 2023-11-24
US20220249563A1 (en) 2022-08-11
CN114072427B (zh) 2024-04-26
JP7748933B2 (ja) 2025-10-03
JP2022542543A (ja) 2022-10-05
CN118420777A (zh) 2024-08-02
EP4527466A2 (en) 2025-03-26
AU2020314509A1 (en) 2022-01-06
KR20220035367A (ko) 2022-03-22
CN114072427A (zh) 2022-02-18
TWI883026B (zh) 2025-05-11

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