CA3125354C - PANTOTHENAMIDE ANALOGUES - Google Patents
PANTOTHENAMIDE ANALOGUESInfo
- Publication number
- CA3125354C CA3125354C CA3125354A CA3125354A CA3125354C CA 3125354 C CA3125354 C CA 3125354C CA 3125354 A CA3125354 A CA 3125354A CA 3125354 A CA3125354 A CA 3125354A CA 3125354 C CA3125354 C CA 3125354C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- propyl
- dioxane
- pantothenamide
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18215980.6A EP3674288A1 (en) | 2018-12-31 | 2018-12-31 | Pantothenamide analogues |
| EP18215980.6 | 2018-12-31 | ||
| PCT/EP2019/087147 WO2020141155A1 (en) | 2018-12-31 | 2019-12-30 | Pantothenamide analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3125354A1 CA3125354A1 (en) | 2020-07-09 |
| CA3125354C true CA3125354C (en) | 2025-03-11 |
Family
ID=64949100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3125354A Active CA3125354C (en) | 2018-12-31 | 2019-12-30 | PANTOTHENAMIDE ANALOGUES |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11572336B2 (https=) |
| EP (2) | EP3674288A1 (https=) |
| JP (1) | JP7423088B2 (https=) |
| CN (1) | CN113286778B (https=) |
| CA (1) | CA3125354C (https=) |
| ES (1) | ES2953044T3 (https=) |
| WO (1) | WO2020141155A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3674288A1 (en) | 2018-12-31 | 2020-07-01 | MMV Medicines for Malaria Venture | Pantothenamide analogues |
| WO2023137529A1 (en) * | 2022-01-24 | 2023-07-27 | Australian National University | Anti-parasite compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000035296A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Improved release of medicament active agents from a chewing gum coating |
| WO2011152720A1 (en) | 2010-05-31 | 2011-12-08 | Umc St. Radboud | Pantothenic acid derivatives and their use in the treatment of microbial infections |
| US20130345270A1 (en) | 2010-11-12 | 2013-12-26 | Waake Forest University Health Sciences | Methods of treating cancer and other disorders |
| EP3215496B1 (en) | 2014-11-06 | 2019-01-02 | Radboud Universitair Medisch Centrum | Pantothenamide analogues |
| WO2017066763A1 (en) * | 2015-10-15 | 2017-04-20 | Cornell University | Proteasome inhibitors and uses thereof |
| EP3674288A1 (en) | 2018-12-31 | 2020-07-01 | MMV Medicines for Malaria Venture | Pantothenamide analogues |
-
2018
- 2018-12-31 EP EP18215980.6A patent/EP3674288A1/en not_active Withdrawn
-
2019
- 2019-12-30 JP JP2021538231A patent/JP7423088B2/ja active Active
- 2019-12-30 US US17/418,871 patent/US11572336B2/en active Active
- 2019-12-30 EP EP19829246.8A patent/EP3906225B1/en active Active
- 2019-12-30 ES ES19829246T patent/ES2953044T3/es active Active
- 2019-12-30 CN CN201980087446.3A patent/CN113286778B/zh active Active
- 2019-12-30 WO PCT/EP2019/087147 patent/WO2020141155A1/en not_active Ceased
- 2019-12-30 CA CA3125354A patent/CA3125354C/en active Active
-
2023
- 2023-01-20 US US18/099,279 patent/US11834391B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP7423088B2 (ja) | 2024-01-29 |
| US20230159437A1 (en) | 2023-05-25 |
| US11834391B2 (en) | 2023-12-05 |
| BR112021011875A2 (pt) | 2021-09-08 |
| US11572336B2 (en) | 2023-02-07 |
| EP3906225A1 (en) | 2021-11-10 |
| EP3674288A1 (en) | 2020-07-01 |
| EP3906225C0 (en) | 2023-07-05 |
| ES2953044T3 (es) | 2023-11-07 |
| BR122023026497A2 (pt) | 2024-01-30 |
| CN113286778B (zh) | 2023-09-22 |
| EP3906225B1 (en) | 2023-07-05 |
| CN113286778A (zh) | 2021-08-20 |
| WO2020141155A1 (en) | 2020-07-09 |
| JP2022515549A (ja) | 2022-02-18 |
| US20220073450A1 (en) | 2022-03-10 |
| CA3125354A1 (en) | 2020-07-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20230510 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 5TH ANNIV.) - STANDARD Year of fee payment: 5 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20241220 |
|
| U11 | Full renewal or maintenance fee paid |
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| D22 | Grant of ip right intended |
Free format text: ST27 STATUS EVENT CODE: A-2-4-D10-D22-D143 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: PRE-GRANT Effective date: 20250218 |
|
| Q17 | Modified document published |
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| F11 | Ip right granted following substantive examination |
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| MPN | Maintenance fee for patent paid |
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| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20251222 |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20251222 |