CN113286778B - 泛酰胺类似物 - Google Patents

泛酰胺类似物 Download PDF

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Publication number
CN113286778B
CN113286778B CN201980087446.3A CN201980087446A CN113286778B CN 113286778 B CN113286778 B CN 113286778B CN 201980087446 A CN201980087446 A CN 201980087446A CN 113286778 B CN113286778 B CN 113286778B
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China
Prior art keywords
compound
plasmodium
compounds
propyl
group
Prior art date
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Active
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CN201980087446.3A
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English (en)
Chinese (zh)
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CN113286778A (zh
Inventor
J·斯哈尔克韦克
P·H·H·赫姆肯斯
K·J·德歇林
R·V·邦内特
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MMV Medicines for Malaria Venture
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MMV Medicines for Malaria Venture
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Publication of CN113286778A publication Critical patent/CN113286778A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201980087446.3A 2018-12-31 2019-12-30 泛酰胺类似物 Active CN113286778B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18215980.6A EP3674288A1 (en) 2018-12-31 2018-12-31 Pantothenamide analogues
EP18215980.6 2018-12-31
PCT/EP2019/087147 WO2020141155A1 (en) 2018-12-31 2019-12-30 Pantothenamide analogues

Publications (2)

Publication Number Publication Date
CN113286778A CN113286778A (zh) 2021-08-20
CN113286778B true CN113286778B (zh) 2023-09-22

Family

ID=64949100

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980087446.3A Active CN113286778B (zh) 2018-12-31 2019-12-30 泛酰胺类似物

Country Status (7)

Country Link
US (2) US11572336B2 (https=)
EP (2) EP3674288A1 (https=)
JP (1) JP7423088B2 (https=)
CN (1) CN113286778B (https=)
CA (1) CA3125354C (https=)
ES (1) ES2953044T3 (https=)
WO (1) WO2020141155A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3674288A1 (en) 2018-12-31 2020-07-01 MMV Medicines for Malaria Venture Pantothenamide analogues
WO2023137529A1 (en) * 2022-01-24 2023-07-27 Australian National University Anti-parasite compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011152720A1 (en) * 2010-05-31 2011-12-08 Umc St. Radboud Pantothenic acid derivatives and their use in the treatment of microbial infections
WO2016072854A2 (en) * 2014-11-06 2016-05-12 Radboud Universitair Medisch Centrum Pantothenamide analogues

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
US20130345270A1 (en) 2010-11-12 2013-12-26 Waake Forest University Health Sciences Methods of treating cancer and other disorders
WO2017066763A1 (en) * 2015-10-15 2017-04-20 Cornell University Proteasome inhibitors and uses thereof
EP3674288A1 (en) 2018-12-31 2020-07-01 MMV Medicines for Malaria Venture Pantothenamide analogues

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011152720A1 (en) * 2010-05-31 2011-12-08 Umc St. Radboud Pantothenic acid derivatives and their use in the treatment of microbial infections
WO2016072854A2 (en) * 2014-11-06 2016-05-12 Radboud Universitair Medisch Centrum Pantothenamide analogues

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Exploring structural motifs necessary for substrate binding in the active site of escherichia colipantothenate kinase;AWUAH EMELIA ET AL;《Bioorganic & Medicinal Chemistry, Pergamon, GB》;第22卷(第12期);3083-3090 *

Also Published As

Publication number Publication date
JP7423088B2 (ja) 2024-01-29
US20230159437A1 (en) 2023-05-25
US11834391B2 (en) 2023-12-05
BR112021011875A2 (pt) 2021-09-08
US11572336B2 (en) 2023-02-07
EP3906225A1 (en) 2021-11-10
EP3674288A1 (en) 2020-07-01
EP3906225C0 (en) 2023-07-05
ES2953044T3 (es) 2023-11-07
BR122023026497A2 (pt) 2024-01-30
EP3906225B1 (en) 2023-07-05
CA3125354C (en) 2025-03-11
CN113286778A (zh) 2021-08-20
WO2020141155A1 (en) 2020-07-09
JP2022515549A (ja) 2022-02-18
US20220073450A1 (en) 2022-03-10
CA3125354A1 (en) 2020-07-09

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