CA3120129A1 - Manufacture of virus - Google Patents

Manufacture of virus Download PDF

Info

Publication number
CA3120129A1
CA3120129A1 CA3120129A CA3120129A CA3120129A1 CA 3120129 A1 CA3120129 A1 CA 3120129A1 CA 3120129 A CA3120129 A CA 3120129A CA 3120129 A CA3120129 A CA 3120129A CA 3120129 A1 CA3120129 A1 CA 3120129A1
Authority
CA
Canada
Prior art keywords
virus
culture
recombinant oncolytic
host cells
bioreactor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3120129A
Other languages
English (en)
French (fr)
Inventor
Paul Andrew Wright
Katy WACK
Mingrui Zhang
Jackie Vasseur
Susan Nicole HOLLEY
August Allen RENSHAW
Guangyu Zhu
Michelle Catherine VENDEL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kalivir Immunotherapeutics Inc
Original Assignee
Western Oncolytics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Western Oncolytics Ltd filed Critical Western Oncolytics Ltd
Publication of CA3120129A1 publication Critical patent/CA3120129A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24151—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA3120129A 2018-11-21 2019-11-21 Manufacture of virus Pending CA3120129A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862770577P 2018-11-21 2018-11-21
US62/770,577 2018-11-21
PCT/US2019/062643 WO2020106975A1 (en) 2018-11-21 2019-11-21 Manufacture of virus

Publications (1)

Publication Number Publication Date
CA3120129A1 true CA3120129A1 (en) 2020-05-28

Family

ID=70774620

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3120129A Pending CA3120129A1 (en) 2018-11-21 2019-11-21 Manufacture of virus

Country Status (8)

Country Link
US (1) US20210277363A1 (https=)
EP (1) EP3884044A4 (https=)
JP (1) JP7625519B2 (https=)
KR (1) KR20210093965A (https=)
CN (1) CN113330111A (https=)
AU (1) AU2019384164A1 (https=)
CA (1) CA3120129A1 (https=)
WO (1) WO2020106975A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4222250A1 (en) * 2020-10-02 2023-08-09 Genelux Corporation Bioreactor production of virus from adherent cells
CN121219392A (zh) * 2023-05-31 2025-12-26 康宁股份有限公司 用于提高固定床生物反应器的细胞收集效率的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0981601B1 (en) 1997-01-31 2006-09-06 Schering Corporation Methods for cultivating cells and propagating viruses
EP2287288B1 (en) * 2002-07-09 2012-11-07 Baxter International Inc. Animal protein free media for cultivation of cells
US20070207461A1 (en) * 2004-02-23 2007-09-06 Crucell Holland B.V. Virus Purification Methods
US8541559B2 (en) * 2006-06-12 2013-09-24 Cytos Biotechnology Ag Process for producing aggregated oligonucleotides
EP2615167A1 (en) * 2006-09-15 2013-07-17 MedImmune, LLC Method for eliminating DNA contaminants from viral preparations
JP2010526546A (ja) 2007-05-14 2010-08-05 バヴァリアン・ノルディック・アクティーゼルスカブ ワクシニアウイルス系及び組換えワクシニアウイルス系ワクチンの精製
US8003363B2 (en) * 2007-05-14 2011-08-23 Bavarian Nordic A/S Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines
US8785173B2 (en) * 2008-09-24 2014-07-22 Medimmune, Llc Methods for purification of viruses
EP2739293B1 (en) * 2011-08-05 2020-06-10 SillaJen Biotherapeutics, Inc. Methods and compositions for production of vaccina virus
US10851350B1 (en) * 2017-06-27 2020-12-01 Genelux Corporation Bioreactor production of virus from adherent cells

Also Published As

Publication number Publication date
JP7625519B2 (ja) 2025-02-03
EP3884044A1 (en) 2021-09-29
CN113330111A (zh) 2021-08-31
US20210277363A1 (en) 2021-09-09
KR20210093965A (ko) 2021-07-28
JP2022508156A (ja) 2022-01-19
WO2020106975A1 (en) 2020-05-28
AU2019384164A1 (en) 2021-06-03
EP3884044A4 (en) 2022-08-31

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