CA3120129A1 - Manufacture of virus - Google Patents

Manufacture of virus Download PDF

Info

Publication number
CA3120129A1
CA3120129A1 CA3120129A CA3120129A CA3120129A1 CA 3120129 A1 CA3120129 A1 CA 3120129A1 CA 3120129 A CA3120129 A CA 3120129A CA 3120129 A CA3120129 A CA 3120129A CA 3120129 A1 CA3120129 A1 CA 3120129A1
Authority
CA
Canada
Prior art keywords
virus
culture
recombinant oncolytic
host cells
bioreactor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3120129A
Other languages
English (en)
French (fr)
Inventor
Paul Andrew Wright
Katy WACK
Mingrui Zhang
Jackie Vasseur
Susan Nicole HOLLEY
August Allen RENSHAW
Guangyu Zhu
Michelle Catherine VENDEL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kalivir Immunotherapeutics Inc
Original Assignee
Western Oncolytics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Western Oncolytics Ltd filed Critical Western Oncolytics Ltd
Publication of CA3120129A1 publication Critical patent/CA3120129A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24151—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA3120129A 2018-11-21 2019-11-21 Manufacture of virus Pending CA3120129A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862770577P 2018-11-21 2018-11-21
US62/770,577 2018-11-21
PCT/US2019/062643 WO2020106975A1 (en) 2018-11-21 2019-11-21 Manufacture of virus

Publications (1)

Publication Number Publication Date
CA3120129A1 true CA3120129A1 (en) 2020-05-28

Family

ID=70774620

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3120129A Pending CA3120129A1 (en) 2018-11-21 2019-11-21 Manufacture of virus

Country Status (8)

Country Link
US (1) US20210277363A1 (enExample)
EP (1) EP3884044A4 (enExample)
JP (1) JP7625519B2 (enExample)
KR (1) KR20210093965A (enExample)
CN (1) CN113330111A (enExample)
AU (1) AU2019384164A1 (enExample)
CA (1) CA3120129A1 (enExample)
WO (1) WO2020106975A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116529382A (zh) * 2020-10-02 2023-08-01 吉恩勒克斯公司 由贴壁细胞在生物反应器中产生病毒
JP2026519561A (ja) * 2023-05-31 2026-06-16 コーニング インコーポレイテッド 固定床バイオリアクタにおける改善される細胞回収効率のための方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL131014A0 (en) 1997-01-31 2001-01-28 Schering Plough Corp Methods for cultivating cells and propagating viruses
DK1520008T3 (da) * 2002-07-09 2012-10-15 Baxter Int Medium frit for dyreprotein til dyrkning af celler
CN1922308A (zh) * 2004-02-23 2007-02-28 克鲁塞尔荷兰公司 病毒纯化方法
SI2032592T1 (sl) * 2006-06-12 2013-10-30 Cytos Biotechnology Ag Postopki za pakiranje oligonukleotidov v virusu-podobne delce RNA bakteriofagov
AU2007347716B2 (en) * 2006-09-15 2013-06-20 Medimmune, Llc MDCK cell lines supporting viral growth to high titers and bioreactor process using the same
US8003363B2 (en) * 2007-05-14 2011-08-23 Bavarian Nordic A/S Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines
AU2008250596C1 (en) 2007-05-14 2010-11-25 Bavarian Nordic A/S Purification of Vaccinia virus- and recombinant Vaccinia virus-based vaccines
KR20110074563A (ko) * 2008-09-24 2011-06-30 메디뮨 엘엘씨 바이러스의 정제 방법
KR102022952B1 (ko) * 2011-08-05 2019-09-20 신라젠(주) 백시니아 바이러스의 생산을 위한 방법 및 조성물
US10851350B1 (en) * 2017-06-27 2020-12-01 Genelux Corporation Bioreactor production of virus from adherent cells

Also Published As

Publication number Publication date
CN113330111A (zh) 2021-08-31
JP2022508156A (ja) 2022-01-19
EP3884044A4 (en) 2022-08-31
WO2020106975A1 (en) 2020-05-28
EP3884044A1 (en) 2021-09-29
JP7625519B2 (ja) 2025-02-03
US20210277363A1 (en) 2021-09-09
KR20210093965A (ko) 2021-07-28
AU2019384164A1 (en) 2021-06-03

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