CA3116866A1 - 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating .alpha.-synucleinopathies, tauopathies, and other disorders - Google Patents

2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating .alpha.-synucleinopathies, tauopathies, and other disorders Download PDF

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Publication number
CA3116866A1
CA3116866A1 CA3116866A CA3116866A CA3116866A1 CA 3116866 A1 CA3116866 A1 CA 3116866A1 CA 3116866 A CA3116866 A CA 3116866A CA 3116866 A CA3116866 A CA 3116866A CA 3116866 A1 CA3116866 A1 CA 3116866A1
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polymorph
composition
water
suppressing
treating
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English (en)
French (fr)
Inventor
Andrew W. Hinman
Charles R. HOLST
Angela MINELLA
Paul Mollard
Sean PINTCHOVSKI
Jeffrey K. TRIMMER
Eric Torrey
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PTC Therapeutics Inc
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PTC Therapeutics Inc
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Priority to CA3255913A priority Critical patent/CA3255913A1/en
Publication of CA3116866A1 publication Critical patent/CA3116866A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/02—Quinones with monocyclic quinoid structure
    • C07C50/04—Benzoquinones, i.e. C6H4O2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/08—Dihydroxy benzenes; Alkylated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/02—Quinones with monocyclic quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA3116866A 2018-10-17 2019-10-17 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating .alpha.-synucleinopathies, tauopathies, and other disorders Pending CA3116866A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3255913A CA3255913A1 (en) 2018-10-17 2019-10-17 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating .alpha.-synucleinopathies, tauopathies, and other disorders

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862747080P 2018-10-17 2018-10-17
US62/747,080 2018-10-17
US201862771570P 2018-11-26 2018-11-26
US62/771,570 2018-11-26
PCT/US2019/056836 WO2020081879A2 (en) 2018-10-17 2019-10-17 2,3,5-TRIMETHYL-6-NONYLCYCLOHEXA-2,5-DIENE-1,4-DIONE FOR SUPPRESSING AND TREATING α-SYNUCLEINOPATHIES, TAUOPATHIES, AND OTHER DISORDERS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3255913A Division CA3255913A1 (en) 2018-10-17 2019-10-17 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating .alpha.-synucleinopathies, tauopathies, and other disorders

Publications (1)

Publication Number Publication Date
CA3116866A1 true CA3116866A1 (en) 2020-04-23

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Family Applications (2)

Application Number Title Priority Date Filing Date
CA3116866A Pending CA3116866A1 (en) 2018-10-17 2019-10-17 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating .alpha.-synucleinopathies, tauopathies, and other disorders
CA3255913A Pending CA3255913A1 (en) 2018-10-17 2019-10-17 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating .alpha.-synucleinopathies, tauopathies, and other disorders

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CA3255913A Pending CA3255913A1 (en) 2018-10-17 2019-10-17 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating .alpha.-synucleinopathies, tauopathies, and other disorders

Country Status (25)

Country Link
US (4) US11174212B2 (https=)
EP (2) EP4257190A3 (https=)
JP (2) JP7586815B2 (https=)
KR (1) KR20210076956A (https=)
CN (2) CN113365616A (https=)
AU (1) AU2019362010A1 (https=)
BR (1) BR112021007153A2 (https=)
CA (2) CA3116866A1 (https=)
CL (1) CL2021000948A1 (https=)
CO (1) CO2021006356A2 (https=)
DK (1) DK3866772T3 (https=)
EC (1) ECSP21034596A (https=)
ES (1) ES2968957T3 (https=)
FI (1) FI3866772T3 (https=)
HU (1) HUE066196T2 (https=)
IL (1) IL282375A (https=)
MX (2) MX2021004329A (https=)
MY (1) MY210324A (https=)
PE (1) PE20211600A1 (https=)
PH (1) PH12021550859A1 (https=)
PL (1) PL3866772T3 (https=)
SG (1) SG11202103887VA (https=)
TN (1) TN2021000075A1 (https=)
WO (1) WO2020081879A2 (https=)
ZA (1) ZA202102619B (https=)

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KR20210076956A (ko) 2021-06-24
EP3866772A2 (en) 2021-08-25
JP2024161510A (ja) 2024-11-19
ECSP21034596A (es) 2021-06-30
DK3866772T3 (da) 2024-01-15
TN2021000075A1 (en) 2023-01-05
SG11202103887VA (en) 2021-05-28
MY210324A (en) 2025-09-11
EP4257190A2 (en) 2023-10-11
CA3255913A1 (en) 2025-10-30
HUE066196T2 (hu) 2024-07-28
US11667596B2 (en) 2023-06-06
US20220220054A1 (en) 2022-07-14
MX2021004329A (es) 2021-06-08
EP3866772B1 (en) 2023-10-11
MX2024005493A (es) 2024-05-23
CL2021000948A1 (es) 2021-11-26
CN113365616A (zh) 2021-09-07
JP7586815B2 (ja) 2024-11-19
ZA202102619B (en) 2024-12-18
CN119185268A (zh) 2024-12-27
PL3866772T3 (pl) 2024-04-08
WO2020081879A2 (en) 2020-04-23
EP4257190A3 (en) 2024-01-03
ES2968957T3 (es) 2024-05-14
JP2022505257A (ja) 2022-01-14
IL282375A (en) 2021-06-30
WO2020081879A3 (en) 2020-07-23
US20230339835A1 (en) 2023-10-26
US20210276937A1 (en) 2021-09-09
PE20211600A1 (es) 2021-08-18
FI3866772T3 (fi) 2024-01-11
US20220106248A1 (en) 2022-04-07
BR112021007153A2 (pt) 2021-07-20
CO2021006356A2 (es) 2021-08-09
US11174212B2 (en) 2021-11-16
US11746077B2 (en) 2023-09-05
AU2019362010A1 (en) 2021-05-20
PH12021550859A1 (en) 2021-12-06

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