CA3111563A1 - Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis - Google Patents

Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis Download PDF

Info

Publication number
CA3111563A1
CA3111563A1 CA3111563A CA3111563A CA3111563A1 CA 3111563 A1 CA3111563 A1 CA 3111563A1 CA 3111563 A CA3111563 A CA 3111563A CA 3111563 A CA3111563 A CA 3111563A CA 3111563 A1 CA3111563 A1 CA 3111563A1
Authority
CA
Canada
Prior art keywords
peptide
subject
amino acid
seq
lung
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3111563A
Other languages
English (en)
French (fr)
Inventor
Dale Christensen
John J. Koleng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lung Therapeutics LLC
Original Assignee
Lung Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lung Therapeutics Inc filed Critical Lung Therapeutics Inc
Publication of CA3111563A1 publication Critical patent/CA3111563A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA3111563A 2018-09-10 2019-09-10 Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis Pending CA3111563A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862728997P 2018-09-10 2018-09-10
US62/728,997 2018-09-10
PCT/US2019/050332 WO2020055812A1 (en) 2018-09-10 2019-09-10 Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis

Publications (1)

Publication Number Publication Date
CA3111563A1 true CA3111563A1 (en) 2020-03-19

Family

ID=69778115

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3111563A Pending CA3111563A1 (en) 2018-09-10 2019-09-10 Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis

Country Status (9)

Country Link
US (4) US11905336B2 (OSRAM)
EP (1) EP3849580A4 (OSRAM)
JP (3) JP7496826B2 (OSRAM)
KR (1) KR102958241B1 (OSRAM)
CN (2) CN121159628A (OSRAM)
AU (2) AU2019339260B2 (OSRAM)
BR (1) BR112021004404A2 (OSRAM)
CA (1) CA3111563A1 (OSRAM)
WO (1) WO2020055812A1 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2875853T3 (es) 2013-03-15 2021-11-11 Univ Texas Método de tratar fibrosis
WO2020055812A1 (en) 2018-09-10 2020-03-19 Lung Therapeutics, Inc. Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis
EP3937966B1 (en) * 2019-03-11 2026-05-06 Rein Therapeutics, Inc. Compositions and methods for protecting type 2 alveolar epithelial cells (aec2)
US20230159608A1 (en) * 2020-04-21 2023-05-25 Lung Therapeutics, Inc. Modified peptide fragments of cav-1 protein and uses thereof
WO2021257816A2 (en) * 2020-06-19 2021-12-23 Lung Therapeutics, Inc. Modified caveolin-1 peptides for the treatment of pathogen-induced lung injury
CA3209638A1 (en) 2021-02-25 2022-09-01 Lung Therapeutics, Inc. Biomarkers for the treatment of interstitial lung disease
US20250041383A1 (en) * 2021-06-17 2025-02-06 Lung Therapeutics, Inc. Modified caveolin-1 peptides for the treatment of post-acute covid-19
EP4419129A4 (en) * 2021-10-22 2025-09-24 Rein Therapeutics Inc MODIFIED CAVEOLIN-1 PEPTIDES FOR THE TREATMENT OF CHRONIC KIDNEY DISEASE

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021387A (en) 1975-11-19 1977-05-03 President And Fellows Of Harvard College Eosinophilotactic tetrapeptides
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
IT1190891B (it) 1982-06-24 1988-02-24 Anic Spa Metodo per la sintesi in fase solida di polipeptidi retroinvertiti
US4816449A (en) 1984-08-09 1989-03-28 Immunetech Pharmaceuticals Immunotherapeutic anti-inflammatory peptide agents
US4613676A (en) 1983-11-23 1986-09-23 Ciba-Geigy Corporation Substituted 5-amino-4-hydroxyvaleryl derivatives
ZA846192B (en) 1984-08-09 1986-03-26 Merck Patent Gmbh Immunotherapeutic polypeptide agents
US5728680A (en) 1987-12-30 1998-03-17 Cytoven J.V. Methods for normalizing numbers of lymphocytes
DK53291D0 (da) 1991-03-25 1991-03-25 Carlbiotech Ltd As Smaa peptider og peptidrelaterede stoffer samt farmaceutiske praeparater indeholdende saadanne forbindelser
US6629646B1 (en) 1991-04-24 2003-10-07 Aerogen, Inc. Droplet ejector with oscillating tapered aperture
US6540154B1 (en) 1991-04-24 2003-04-01 Aerogen, Inc. Systems and methods for controlling fluid feed to an aerosol generator
US5938117A (en) 1991-04-24 1999-08-17 Aerogen, Inc. Methods and apparatus for dispensing liquids as an atomized spray
US5277175A (en) 1991-07-12 1994-01-11 Riggs John H Continuous flow nebulizer apparatus and method, having means maintaining a constant-level reservoir
GB9120005D0 (en) 1991-09-19 1991-11-06 Wellcome Found Method of administering phospholipid dispersions
US5355872B1 (en) 1992-03-04 1998-10-20 John H Riggs Low flow rate nebulizer apparatus and method of nebulization
US5284133A (en) 1992-07-23 1994-02-08 Armstrong Pharmaceuticals, Inc. Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means
US5329028A (en) 1992-08-05 1994-07-12 Genentech, Inc. Carbohydrate-directed cross-linking reagents
CN1091138A (zh) 1992-08-27 1994-08-24 迪金研究有限公司 疫苗
US5358934A (en) 1992-12-11 1994-10-25 The United States Of America As Represented By The Secretary Of Agriculture Materials and methods for control of pests
US5559209A (en) 1993-02-18 1996-09-24 The General Hospital Corporation Regulator regions of G proteins
US5497763A (en) 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
WO1997009085A1 (en) 1995-09-06 1997-03-13 Ryder Steven L Variable oxygen concentration high-flow nebulizer
US5823179A (en) 1996-02-13 1998-10-20 1263152 Ontario Inc. Nebulizer apparatus and method
ES2140998B1 (es) 1996-05-13 2000-10-16 Univ Sevilla Procedimiento de atomizacion de liquidos.
US6126939A (en) 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof
US6017735A (en) 1997-01-23 2000-01-25 Marie Curie Cancer Care Materials and methods for intracellular transport and their uses
US20030113271A1 (en) 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
IT1291122B1 (it) 1997-03-28 1998-12-29 Sar Spa Micropompa per la nebulizzazione di fluidi con valvola dosatrice perfezionata
US6096707A (en) 1997-07-11 2000-08-01 Biotie Therapies Ltd. Integrin binding peptide and use thereof
US6044841A (en) 1997-08-29 2000-04-04 1263152 Ontario Inc. Breath actuated nebulizer with valve assembly having a relief piston
US6041776A (en) 1998-05-14 2000-03-28 Briggs, Iii; Stephen W. Medical nebulization device
US6354516B1 (en) 1999-11-02 2002-03-12 Aradigm Corporation Pore structures for reduced pressure aerosolization
SE9900369D0 (sv) 1999-02-04 1999-02-04 Siemens Elema Ab Ultrasonic nebuliser
US6328030B1 (en) 1999-03-12 2001-12-11 Daniel E. Kidwell Nebulizer for ventilation system
EP1076091A1 (en) 1999-08-09 2001-02-14 Universite Catholique De Louvain Medicament for the prevention and/or the treatment of ischemic heart and peripheral vascular diseases, tumour and wounds
AU2001280917A1 (en) 2000-08-02 2002-02-13 Research Development Foundation Jet nebulizer assembly for home administration of drugs in aerosols
US20020077283A1 (en) 2000-09-08 2002-06-20 Sessa William C. Caveolin peptides and their use as therapeutics
US6732944B2 (en) 2001-05-02 2004-05-11 Aerogen, Inc. Base isolated nebulizing device and methods
GB0119852D0 (en) 2001-08-15 2001-10-10 Univ York Baculovirus
MXPA04006629A (es) 2002-01-07 2004-11-10 Aerogen Inc Aparatos y metodos para nebulizar fluidos para inhalacion.
ES2603067T3 (es) 2002-01-15 2017-02-23 Novartis Ag Métodos y sistemas para hacer funcionar un generador de aerosol
WO2003086278A2 (en) 2002-04-05 2003-10-23 Board Of Regents, The University Of Texas System Intrapleural single-chain urokinase alone or complexed to its soluble receptor protects against pleural adhesions
JP2005530765A (ja) 2002-05-07 2005-10-13 ネクター セラピューティクス 乾燥粉末吸入器のためのカプセル及びそれを製造及び使用する方法
US20040175384A1 (en) 2003-12-12 2004-09-09 Mohapatra Shyam S. Protein kinase C as a target for the treatment of respiratory syncytial virus
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
US20070207158A1 (en) 2003-06-17 2007-09-06 Harrison Roger G Conjugate for the specific targeting of anticancer agents to tumor cells or tumor vasculature and production thereof
GB0321607D0 (en) 2003-09-15 2003-10-15 Vectura Ltd Manufacture of pharmaceutical compositions
US7625865B2 (en) 2004-03-26 2009-12-01 Universita Degli Studi Di Parma Insulin highly respirable microparticles
CA2568428C (en) 2004-05-25 2020-12-29 Attenuon, Llc Ligands binding the complex of urokinase-type plasminogen activator (upa) and its receptor (upar) that inhibit downstream upar interactions: identification and use in diagnosis or therapy
ES2514470T3 (es) 2005-05-25 2014-10-28 Aerogen, Inc. Sistemas y métodos de vibración
TWI299993B (en) 2005-12-15 2008-08-21 Dev Center Biotechnology Aqueous inhalation pharmaceutical composition
US8058227B2 (en) 2006-10-03 2011-11-15 Medical University Of South Carolina Method of treating fibrosis in a subject in need thereof comprising administering a composition comprising a CSD
EP2074142A4 (en) 2006-10-19 2010-10-27 Angiochem Inc COMPOUNDS FOR STIMULATING THE FUNCTION OF P-GLYCOPROTEIN AND APPLICATIONS THEREOF
US20090068258A1 (en) 2007-08-28 2009-03-12 Lisanti Michael P Caveolin-mimetic peptide for prevention and treatment of pulmonary hypertension and right ventricular hypertrophy
TW200938222A (en) 2007-12-13 2009-09-16 Glaxo Group Ltd Compositions for pulmonary delivery
US8697840B2 (en) * 2008-03-05 2014-04-15 Board Of Regents, The University Of Texas System Peptide inhibition of lung epithelial apoptosis and pulmonary fibrosis
WO2009152453A2 (en) 2008-06-12 2009-12-17 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating pulmonary hypertension
AU2009291747B2 (en) 2008-09-10 2016-05-26 Genentech, Inc. Methods for inhibiting ocular angiogenesis
DK2349314T3 (da) 2008-10-21 2013-05-27 Baxter Int Lyofiliserede præparater af rekombinant VWF
GB2466121B (en) 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
SG176053A1 (en) 2009-05-15 2011-12-29 Intermune Inc Methods of treating hiv patients with anti-fibrotics
US20110129444A1 (en) 2009-09-28 2011-06-02 Intermune, Inc Novel macrocyclic inhibitors of hepatitis c virus replication
ES2738114T3 (es) 2010-02-11 2020-01-20 Ablynx Nv Métodos y composiciones para la preparación de aerosoles
EP2635686B1 (en) * 2010-11-05 2018-03-28 The Regents of The University of California Neuronal specific targeting of caveolin expression to restore synaptic signaling and improve cognitive function in the neurodegenerative brain and motor function in spinal cord
SG11201405830VA (en) 2012-03-27 2014-10-30 Genentech Inc Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis
WO2013184482A1 (en) 2012-06-04 2013-12-12 Yale University Method of treating and preventing ocular angiogenesis
BR112015022831A2 (pt) 2013-03-13 2017-08-22 Forest Laboratories Holdings Ltd Composições farmacêuticas micronizadas
ES2875853T3 (es) 2013-03-15 2021-11-11 Univ Texas Método de tratar fibrosis
CN104274827B (zh) 2013-07-01 2020-07-14 上海贺普药业股份有限公司 贺普拉肽的制剂
PE20160789A1 (es) 2013-11-04 2016-08-17 Univ Texas Composiciones y metodos para admistracion de una enzima a las vias respiratorias de un sujeto
ES2806027T3 (es) * 2013-11-26 2021-02-16 Univ Yale Nuevas composiciones penetrantes de células y métodos de uso de las mismas
JP6692751B2 (ja) 2013-11-26 2020-05-13 イーアンドビー テクノロジーズ エルエルシー 新規カベオリンモジュレーターを使用する自己免疫および／または炎症疾患の治療
KR102698051B1 (ko) 2015-02-27 2024-08-26 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 폴리펩타이드 치료제 및 이의 용도
KR101845590B1 (ko) 2015-09-25 2018-04-05 단국대학교 천안캠퍼스 산학협력단 유전자를 이용한 폐암 예후예측용 조성물
CN107216394B (zh) * 2017-06-21 2020-10-09 江南大学 一种小窝蛋白-1脚手架区融合多肽的制备方法及其应用
US20190224243A1 (en) 2018-01-25 2019-07-25 Musc Foundation For Research Development Enhancement of the Beneficial Effects of Mesenchymal Stem Cell Treatment by the Caveolin-1 Scaffolding Domain Peptide and Subdomains
WO2020055812A1 (en) 2018-09-10 2020-03-19 Lung Therapeutics, Inc. Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis
WO2020055824A1 (en) 2018-09-10 2020-03-19 Board of Regents, The University of the Texas System Dry powder formulation of caveolin-1 peptides and methods of use thereof
US20240082342A1 (en) 2018-11-21 2024-03-14 Board Of Regents, The University Of Texas System Peptide therapeutics for increasing lung cell viability
US20220370544A1 (en) 2018-11-21 2022-11-24 Board Of Regents, The University Of Texas System Peptide therapeutics for acute and chronic airway and alveolar diseases
EP3937966B1 (en) * 2019-03-11 2026-05-06 Rein Therapeutics, Inc. Compositions and methods for protecting type 2 alveolar epithelial cells (aec2)
US12097222B2 (en) 2019-06-06 2024-09-24 Spiritus Therapeutics, Inc. Methods for attenuating viral infection and for treating lung injury
CN111671886B (zh) 2020-03-05 2022-11-15 上海甘翼生物医药科技有限公司 一种预防高危易感人群感染冠状病毒或发生冠状病毒感染疾病的药物组合及其用途
US20230159608A1 (en) 2020-04-21 2023-05-25 Lung Therapeutics, Inc. Modified peptide fragments of cav-1 protein and uses thereof
WO2021257816A2 (en) 2020-06-19 2021-12-23 Lung Therapeutics, Inc. Modified caveolin-1 peptides for the treatment of pathogen-induced lung injury
CA3209638A1 (en) 2021-02-25 2022-09-01 Lung Therapeutics, Inc. Biomarkers for the treatment of interstitial lung disease
US12449810B2 (en) 2021-03-01 2025-10-21 The Boeing Company Autonomous maneuver generation to mate connectors
US20250041383A1 (en) 2021-06-17 2025-02-06 Lung Therapeutics, Inc. Modified caveolin-1 peptides for the treatment of post-acute covid-19
EP4419129A4 (en) 2021-10-22 2025-09-24 Rein Therapeutics Inc MODIFIED CAVEOLIN-1 PEPTIDES FOR THE TREATMENT OF CHRONIC KIDNEY DISEASE

Also Published As

Publication number Publication date
US20240018186A1 (en) 2024-01-18
KR20210084453A (ko) 2021-07-07
CN121159628A (zh) 2025-12-19
BR112021004404A2 (pt) 2021-08-03
US11905336B2 (en) 2024-02-20
CN112739367A (zh) 2021-04-30
EP3849580A4 (en) 2022-06-15
CN112739367B (zh) 2025-06-06
JP2022500078A (ja) 2022-01-04
AU2019339260B2 (en) 2025-06-26
EP3849580A1 (en) 2021-07-21
AU2025234225A1 (en) 2025-10-09
JP2024071397A (ja) 2024-05-24
KR102958241B1 (ko) 2026-04-30
WO2020055812A1 (en) 2020-03-19
US12497431B2 (en) 2025-12-16
US20260062444A1 (en) 2026-03-05
JP7737492B2 (ja) 2025-09-10
US11787838B2 (en) 2023-10-17
JP7496826B2 (ja) 2024-06-07
JP2025184877A (ja) 2025-12-18
US20230212223A1 (en) 2023-07-06
US20210347820A1 (en) 2021-11-11
AU2019339260A1 (en) 2021-03-25

Similar Documents

Publication Publication Date Title
US11787838B2 (en) Modified peptide fragments of CAV-1 protein and the use thereof in the treatment of fibrosis
US12280089B2 (en) Dry powder formulation of caveolin-1 peptides and methods of use thereof
US20250268977A1 (en) Compositions and methods for protecting type 2 alveolar epithelial cells (aec2)
US20230226149A1 (en) Modified caveolin-1 peptides for the treatment of pathogen-induced lung injury
WO2021216659A1 (en) Modified peptide fragments of cav-1 protein and uses thereof
US20250041383A1 (en) Modified caveolin-1 peptides for the treatment of post-acute covid-19
US20250262273A1 (en) Modified caveolin-1 peptides for the treatment of chronic kidney disease
KR20260061289A (ko) Cav-1 단백질의 변형된 펩타이드 단편 및 섬유증의 치료에 있어서 이의 용도

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20220927

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 5TH ANNIV.) - STANDARD

Year of fee payment: 5

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20240904

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20240904

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20240904

R11 Change to the name of applicant or owner or transfer of ownership requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-R10-R11-R127 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TRANSFER RECORDAL REQUEST OR RESPONSE

Effective date: 20250407

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20250407

R14 Transfer of ownership recorded

Free format text: ST27 STATUS EVENT CODE: A-2-2-R10-R14-R129 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TRANSFER REQUIREMENTS DETERMINED COMPLIANT

Effective date: 20250708

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 6TH ANNIV.) - STANDARD

Year of fee payment: 6

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250901

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250901

D22 Grant of ip right intended

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D22-D128 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ALLOWANCE REQUIREMENTS DETERMINED COMPLIANT

Effective date: 20260114

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20260114